Gene Page: GBP4

Summary ?
GeneID115361
SymbolGBP4
SynonymsMpa2
Descriptionguanylate binding protein 4
ReferenceMIM:612466|HGNC:HGNC:20480|Ensembl:ENSG00000162654|HPRD:13570|Vega:OTTHUMG00000010663
Gene typeprotein-coding
Map location1p22.2
Pascal p-value0.958
Sherlock p-value0.936
DEG p-valueDEG:Sanders_2014:DS1_p=0.160:DS1_beta=0.017100:DS2_p=2.50e-03:DS2_beta=-0.141:DS2_FDR=3.02e-02
Fetal beta-0.381
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DEG:Sanders_2013MicroarrayWhole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2745260chr111586676GBP41153610.19trans
rs17109968chr154633542GBP41153610.16trans
rs12036740chr158432174GBP41153610.09trans
rs12041093chr158462509GBP41153610.03trans
rs12023109chr158482942GBP41153610.03trans
rs473019chr172296394GBP41153610.06trans
rs11799385chr179449863GBP41153610.13trans
rs17121311chr1100314968GBP41153610.01trans
rs1342707chr1147264296GBP41153611.072E-4trans
rs3766034chr1169087664GBP41153610trans
rs12748624chr1169189770GBP41153610.06trans
rs4027083chr1234452908GBP41153610.07trans
rs10495652chr217139288GBP41153611.097E-6trans
rs6531271chr217139932GBP41153611.097E-6trans
rs12620194chr217148003GBP41153611.097E-6trans
rs17042744chr221824821GBP41153610.01trans
rs2113625chr221828617GBP41153610.01trans
rs7563186chr221844897GBP41153611.689E-4trans
rs17680142chr221849670GBP41153610.01trans
rs6547745chr221852551GBP41153610.01trans
rs6758775chr221887142GBP41153610.13trans
rs17042868chr221895688GBP41153610.01trans
rs11893111chr221910980GBP41153610.01trans
rs10490050chr240571949GBP41153610.06trans
snp_a-21861470GBP41153610.1trans
rs9860881chr340278954GBP41153610.19trans
snp_a-22589880GBP41153610.01trans
rs17577568chr5133167214GBP41153610.06trans
rs10491308chr5140678473GBP41153610.03trans
rs10462960chr5166125559GBP41153610.01trans
rs2962835chr5176331831GBP41153610.01trans
rs10516136chr5176381368GBP41153610trans
rs10069302chr5176461594GBP41153610.05trans
rs6881260chr5176464003GBP41153610.05trans
rs6860827chr5176479648GBP41153610.05trans
rs6887893chr5176493262GBP41153610.05trans
rs121959840GBP41153610.15trans
rs16889143chr636757182GBP41153610.03trans
rs16869716chr671743471GBP41153611.585E-6trans
rs1080960chr684815420GBP41153610.15trans
rs133627530GBP41153610.15trans
rs6455821chr6162825101GBP41153610.11trans
rs344468chr7146419325GBP41153610.12trans
rs7790094chr7152786528GBP41153610.12trans
rs4726262chr7152855641GBP41153610.08trans
rs6464313chr7152855864GBP41153610.16trans
rs16932340chr866684243GBP41153610trans
rs10827397chr1019722202GBP41153610.01trans
rs7907015chr1019921035GBP41153610.02trans
rs10827728chr1019930366GBP41153610.02trans
rs10509151chr1063358651GBP41153610.12trans
rs2393827chr1063563590GBP41153617.427E-4trans
rs2588986chr1063568258GBP41153617.427E-4trans
rs2053642chr1063613118GBP41153610.01trans
rs11027580chr1123891659GBP41153610.16trans
rs11027591chr1123900616GBP41153610.15trans
rs17133330chr1199097728GBP41153610.07trans
rs2592926chr11127251272GBP41153610.02trans
rs2618221chr11127251893GBP41153610.03trans
rs12577873chr11127261987GBP41153610.02trans
rs11220901chr11127274538GBP41153610.01trans
rs10893679chr11127281378GBP41153610.01trans
rs17395192chr1226643930GBP41153610.03trans
rs11613629chr12104972976GBP41153610.01trans
rs6492262chr13111000751GBP41153610trans
rs7143284chr1458320614GBP41153610.02trans
rs927248chr1458321206GBP41153610.02trans
rs11158940chr1472522541GBP41153610.14trans
rs4774826chr1556070006GBP41153616.758E-6trans
rs6498459chr1613795898GBP41153610.05trans
rs16995164chrX148536507GBP41153610.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME INTERFERON GAMMA SIGNALING 6348All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
WATANABE ULCERATIVE COLITIS WITH CANCER DN 149All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 7151All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
YU MYC TARGETS DN 5538All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 3521All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 7756All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 10767All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 13179All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 15 3523All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217131All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 13676All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163111All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 12881All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway