Summary ?
GeneID116519
SymbolAPOA5
SynonymsAPOAV|RAP3
Descriptionapolipoprotein A-V
ReferenceMIM:606368|HGNC:HGNC:17288|Ensembl:ENSG00000110243|HPRD:06966|Vega:OTTHUMG00000046116
Gene typeprotein-coding
Map location11q23
Pascal p-value0.466

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005319lipid transporter activityIEA-
GO:0008201heparin bindingIDA15878877 
GO:0008201heparin bindingIDA17326667 
GO:0017129triglyceride bindingIEA-
GO:0031210phosphatidylcholine bindingIDA16806135 
GO:0019899enzyme bindingIDA15178420 
GO:0050750low-density lipoprotein receptor bindingIPI17326667 
GO:0060229lipase activator activityIMP15178420 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006869lipid transportIEA-
GO:0042246tissue regenerationIEP11577099 
GO:0051006positive regulation of lipoprotein lipase activityIDA15178420 |16806135 
GO:0042159lipoprotein catabolic processIEA-
GO:0019433triacylglycerol catabolic processIMP15178420 
GO:0050996positive regulation of lipid catabolic processIDA16806135 
GO:0055090acylglycerol homeostasisIDA11588264 
GO:0055090acylglycerol homeostasisIMP15178420 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIDA11577099 
GO:0034364high-density lipoprotein particleIDA15528295 
GO:0034362low-density lipoprotein particleIDA15528295 
GO:0034361very-low-density lipoprotein particleIDA15528295 
GO:0042627chylomicronIDA15528295 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PPAR SIGNALING PATHWAY 6947All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 4637All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 2824All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT 1615All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169111All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 7651All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2 8650All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-245359m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG