Gene Page: APOA5
Summary ?
GeneID | 116519 |
Symbol | APOA5 |
Synonyms | APOAV|RAP3 |
Description | apolipoprotein A-V |
Reference | MIM:606368|HGNC:HGNC:17288|Ensembl:ENSG00000110243|HPRD:06966|Vega:OTTHUMG00000046116 |
Gene type | protein-coding |
Map location | 11q23 |
Pascal p-value | 0.466 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
GSMA_I | Genome scan meta-analysis | Psr: 0.006 | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005319 | lipid transporter activity | IEA | - | |
GO:0008201 | heparin binding | IDA | 15878877 | |
GO:0008201 | heparin binding | IDA | 17326667 | |
GO:0017129 | triglyceride binding | IEA | - | |
GO:0031210 | phosphatidylcholine binding | IDA | 16806135 | |
GO:0019899 | enzyme binding | IDA | 15178420 | |
GO:0050750 | low-density lipoprotein receptor binding | IPI | 17326667 | |
GO:0060229 | lipase activator activity | IMP | 15178420 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006869 | lipid transport | IEA | - | |
GO:0042246 | tissue regeneration | IEP | 11577099 | |
GO:0051006 | positive regulation of lipoprotein lipase activity | IDA | 15178420 |16806135 | |
GO:0042159 | lipoprotein catabolic process | IEA | - | |
GO:0019433 | triacylglycerol catabolic process | IMP | 15178420 | |
GO:0050996 | positive regulation of lipid catabolic process | IDA | 16806135 | |
GO:0055090 | acylglycerol homeostasis | IDA | 11588264 | |
GO:0055090 | acylglycerol homeostasis | IMP | 15178420 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005576 | extracellular region | IDA | 11577099 | |
GO:0034364 | high-density lipoprotein particle | IDA | 15528295 | |
GO:0034362 | low-density lipoprotein particle | IDA | 15528295 | |
GO:0034361 | very-low-density lipoprotein particle | IDA | 15528295 | |
GO:0042627 | chylomicron | IDA | 15528295 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG PPAR SIGNALING PATHWAY | 69 | 47 | All SZGR 2.0 genes in this pathway |
REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | 46 | 37 | All SZGR 2.0 genes in this pathway |
REACTOME LIPOPROTEIN METABOLISM | 28 | 24 | All SZGR 2.0 genes in this pathway |
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | 16 | 15 | All SZGR 2.0 genes in this pathway |
UEDA PERIFERAL CLOCK | 169 | 111 | All SZGR 2.0 genes in this pathway |
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN | 179 | 97 | All SZGR 2.0 genes in this pathway |
YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2 | 86 | 50 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-24 | 53 | 59 | m8 | hsa-miR-24SZ | UGGCUCAGUUCAGCAGGAACAG |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.