Gene Page: GSTO2
Summary ?
| GeneID | 119391 |
| Symbol | GSTO2 |
| Synonyms | GSTO 2-2|bA127L20.1 |
| Description | glutathione S-transferase omega 2 |
| Reference | MIM:612314|HGNC:HGNC:23064|Ensembl:ENSG00000065621|HPRD:13614|Vega:OTTHUMG00000019006 |
| Gene type | protein-coding |
| Map location | 10q25.1 |
| Pascal p-value | 5.39E-4 |
| Sherlock p-value | 0.003 |
| Fetal beta | -1.511 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11191940 | chr10 | 105941043 | GSTO2 | 119391 | 0.1 | cis | ||
| rs11191953 | chr10 | 105982726 | GSTO2 | 119391 | 0.16 | cis | ||
| rs4925 | chr10 | 106022788 | GSTO2 | 119391 | 0 | cis | ||
| rs156697 | chr10 | 106039184 | GSTO2 | 119391 | 2.934E-6 | cis | ||
| rs276203 | chr10 | 106039302 | GSTO2 | 119391 | 2.896E-6 | cis | ||
| rs156699 | chr10 | 106053640 | GSTO2 | 119391 | 1.101E-5 | cis | ||
| rs157081 | chr10 | 106055023 | GSTO2 | 119391 | 1.731E-5 | cis | ||
| rs10491046 | chr10 | 106071000 | GSTO2 | 119391 | 5.7E-4 | cis | ||
| rs10883991 | chr10 | 106077585 | GSTO2 | 119391 | 0.02 | cis | ||
| rs276219 | chr10 | 106087511 | GSTO2 | 119391 | 0.08 | cis | ||
| rs276215 | chr10 | 106089381 | GSTO2 | 119391 | 0.04 | cis | ||
| rs276213 | chr10 | 106091094 | GSTO2 | 119391 | 0.17 | cis | ||
| rs7083064 | chr10 | 106138538 | GSTO2 | 119391 | 0.18 | cis | ||
| rs4925 | chr10 | 106022788 | GSTO2 | 119391 | 0.1 | trans | ||
| rs156697 | chr10 | 106039184 | GSTO2 | 119391 | 5.015E-4 | trans | ||
| rs276203 | chr10 | 106039302 | GSTO2 | 119391 | 4.928E-4 | trans | ||
| rs156699 | chr10 | 106053640 | GSTO2 | 119391 | 0 | trans | ||
| rs157081 | chr10 | 106055023 | GSTO2 | 119391 | 0 | trans | ||
| rs10491046 | chr10 | 106071000 | GSTO2 | 119391 | 0.04 | trans | ||
| rs612406 | 10 | 106005735 | GSTO2 | ENSG00000065621.10 | 1.623E-6 | 0 | -22896 | gtex_brain_ba24 |
| rs17883150 | 10 | 106013050 | GSTO2 | ENSG00000065621.10 | 2.593E-7 | 0 | -15581 | gtex_brain_ba24 |
| rs2164624 | 10 | 106013445 | GSTO2 | ENSG00000065621.10 | 2.474E-7 | 0 | -15186 | gtex_brain_ba24 |
| rs397752173 | 10 | 106014764 | GSTO2 | ENSG00000065621.10 | 1.838E-6 | 0 | -13867 | gtex_brain_ba24 |
| rs10883990 | 10 | 106018558 | GSTO2 | ENSG00000065621.10 | 1.285E-7 | 0 | -10073 | gtex_brain_ba24 |
| rs2282326 | 10 | 106020398 | GSTO2 | ENSG00000065621.10 | 4.389E-8 | 0 | -8233 | gtex_brain_ba24 |
| rs4925 | 10 | 106022789 | GSTO2 | ENSG00000065621.10 | 1.258E-7 | 0 | -5842 | gtex_brain_ba24 |
| rs11191979 | 10 | 106024867 | GSTO2 | ENSG00000065621.10 | 1.258E-7 | 0 | -3764 | gtex_brain_ba24 |
| rs1147611 | 10 | 106025258 | GSTO2 | ENSG00000065621.10 | 4.331E-8 | 0 | -3373 | gtex_brain_ba24 |
| rs45596840 | 10 | 106028154 | GSTO2 | ENSG00000065621.10 | 1.238E-7 | 0 | -477 | gtex_brain_ba24 |
| rs641071 | 10 | 106028157 | GSTO2 | ENSG00000065621.10 | 4.267E-8 | 0 | -474 | gtex_brain_ba24 |
| rs11191980 | 10 | 106032213 | GSTO2 | ENSG00000065621.10 | 2.862E-8 | 0 | 3582 | gtex_brain_ba24 |
| rs568526 | 10 | 106033439 | GSTO2 | ENSG00000065621.10 | 8.599E-9 | 0 | 4808 | gtex_brain_ba24 |
| rs17826034 | 10 | 106033504 | GSTO2 | ENSG00000065621.10 | 2.862E-8 | 0 | 4873 | gtex_brain_ba24 |
| rs2297235 | 10 | 106034491 | GSTO2 | ENSG00000065621.10 | 2.862E-8 | 0 | 5860 | gtex_brain_ba24 |
| rs276204 | 10 | 106035313 | GSTO2 | ENSG00000065621.10 | 8.599E-9 | 0 | 6682 | gtex_brain_ba24 |
| rs157077 | 10 | 106037894 | GSTO2 | ENSG00000065621.10 | 7.852E-7 | 0 | 9263 | gtex_brain_ba24 |
| rs7099030 | 10 | 106038347 | GSTO2 | ENSG00000065621.10 | 3.782E-8 | 0 | 9716 | gtex_brain_ba24 |
| rs156697 | 10 | 106039185 | GSTO2 | ENSG00000065621.10 | 8.599E-9 | 0 | 10554 | gtex_brain_ba24 |
| rs276203 | 10 | 106039303 | GSTO2 | ENSG00000065621.10 | 8.599E-9 | 0 | 10672 | gtex_brain_ba24 |
| rs6584592 | 10 | 106039780 | GSTO2 | ENSG00000065621.10 | 3.839E-8 | 0 | 11149 | gtex_brain_ba24 |
| rs1865926 | 10 | 106042502 | GSTO2 | ENSG00000065621.10 | 4.301E-8 | 0 | 13871 | gtex_brain_ba24 |
| rs7079338 | 10 | 106043132 | GSTO2 | ENSG00000065621.10 | 7.904E-8 | 0 | 14501 | gtex_brain_ba24 |
| rs397712198 | 10 | 106045962 | GSTO2 | ENSG00000065621.10 | 3.507E-8 | 0 | 17331 | gtex_brain_ba24 |
| rs276210 | 10 | 106046403 | GSTO2 | ENSG00000065621.10 | 2.077E-8 | 0 | 17772 | gtex_brain_ba24 |
| rs987247 | 10 | 106046768 | GSTO2 | ENSG00000065621.10 | 6.741E-8 | 0 | 18137 | gtex_brain_ba24 |
| rs157076 | 10 | 106048294 | GSTO2 | ENSG00000065621.10 | 2.043E-8 | 0 | 19663 | gtex_brain_ba24 |
| rs11191989 | 10 | 106050315 | GSTO2 | ENSG00000065621.10 | 6.714E-8 | 0 | 21684 | gtex_brain_ba24 |
| rs156699 | 10 | 106053641 | GSTO2 | ENSG00000065621.10 | 2.069E-8 | 0 | 25010 | gtex_brain_ba24 |
| rs157081 | 10 | 106055024 | GSTO2 | ENSG00000065621.10 | 2.069E-8 | 0 | 26393 | gtex_brain_ba24 |
| rs157080 | 10 | 106055963 | GSTO2 | ENSG00000065621.10 | 2.069E-8 | 0 | 27332 | gtex_brain_ba24 |
| rs3740466 | 10 | 106061169 | GSTO2 | ENSG00000065621.10 | 1.196E-7 | 0 | 32538 | gtex_brain_ba24 |
| rs397760147 | 10 | 106065999 | GSTO2 | ENSG00000065621.10 | 7.905E-8 | 0 | 37368 | gtex_brain_ba24 |
| rs11191999 | 10 | 106066436 | GSTO2 | ENSG00000065621.10 | 1.656E-6 | 0 | 37805 | gtex_brain_ba24 |
| rs11192001 | 10 | 106067978 | GSTO2 | ENSG00000065621.10 | 6.714E-8 | 0 | 39347 | gtex_brain_ba24 |
| rs201853039 | 10 | 106069081 | GSTO2 | ENSG00000065621.10 | 2.75E-6 | 0 | 40450 | gtex_brain_ba24 |
| rs199914302 | 10 | 106069085 | GSTO2 | ENSG00000065621.10 | 2.279E-7 | 0 | 40454 | gtex_brain_ba24 |
| rs10491046 | 10 | 106071001 | GSTO2 | ENSG00000065621.10 | 6.714E-8 | 0 | 42370 | gtex_brain_ba24 |
| rs276209 | 10 | 106072527 | GSTO2 | ENSG00000065621.10 | 2.069E-8 | 0 | 43896 | gtex_brain_ba24 |
| rs505701 | 10 | 106073566 | GSTO2 | ENSG00000065621.10 | 2.069E-8 | 0 | 44935 | gtex_brain_ba24 |
| rs11595547 | 10 | 106076414 | GSTO2 | ENSG00000065621.10 | 1.538E-7 | 0 | 47783 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLUTATHIONE METABOLISM | 50 | 34 | All SZGR 2.0 genes in this pathway |
| KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | 70 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 51 | 36 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUTATHIONE CONJUGATION | 23 | 13 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE II CONJUGATION | 70 | 42 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS DN | 232 | 139 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE DN | 373 | 196 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |