Gene Page: CPXM2

Summary ?
GeneID119587
SymbolCPXM2
SynonymsCPX2|UNQ676
Descriptioncarboxypeptidase X (M14 family), member 2
ReferenceHGNC:HGNC:26977|Ensembl:ENSG00000121898|HPRD:08517|Vega:OTTHUMG00000019206
Gene typeprotein-coding
Map location10q26.13
Pascal p-value0.176
Fetal beta-1.505
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03487 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1619771710125650957CPXM21.12E-5-0.3730.013DMG:Wockner_2014
cg1467640710125651370CPXM22.56E-5-0.4790.017DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7540312chr143299535CPXM21195870.07trans
rs17131472chr191962966CPXM21195870.03trans
rs2976809chr3125451738CPXM21195870.02trans
rs16889842chr49872012CPXM21195870.2trans
rs10050805chr530805352CPXM21195870.09trans
rs12663450chr638135729CPXM21195870.13trans
rs6455226chr667930295CPXM21195870trans
rs3823550chr7137346101CPXM21195870.19trans
rs7081666chr1047673800CPXM21195870.11trans
rs10879027chr1270237156CPXM21195870.12trans
rs6095741chr2048666589CPXM21195876.547E-7trans
rs5991662chrX43335796CPXM21195870trans
rs1545676chrX93530472CPXM21195870.04trans
rs242163chrX132311662CPXM21195870.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SAP1300.960.97
QRICH10.950.95
PRR30.950.96
PHF120.940.94
FBXO420.940.95
LSM14B0.940.96
NCOA60.940.96
ZNF3170.940.94
ZNF3840.940.95
SEC24C0.940.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.80-0.91
MT-CO2-0.79-0.92
AF347015.27-0.79-0.91
AF347015.33-0.78-0.89
MT-CYB-0.76-0.88
S100B-0.76-0.87
AF347015.8-0.76-0.90
FXYD1-0.76-0.88
COPZ2-0.75-0.83
AIFM3-0.74-0.79

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004181metallocarboxypeptidase activityIEA-
GO:0008270zinc ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0006508proteolysisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
COWLING MYCN TARGETS 4327All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 8056All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway