SZGR2

Summary ?

GeneID	121504
Symbol	HIST4H4
Synonyms	H4/p
Description	histone cluster 4, H4
Reference	MIM:615069\|HGNC:HGNC:20510\|HPRD:13662\|
Gene type	protein-coding
Map location	12p12.3
Pascal p-value	0.029
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs2948491	chrX	40180688	HIST4H4	121504		0.2		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALB	DKFZp779N1935 \| PRO0883 \| PRO0903 \| PRO1341	albumin	HIST4H4 (Histone 4) interacts with the ALB gene (albumin).	BIND	15616580
ASF1A	CGI-98 \| CIA \| DKFZp547E2110 \| HSPC146	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	Asf1a interacts with H4AcK12. This interaction was modeled on a demonstrated interaction between Asf1a from an unspecified species and human H4AcK12.	BIND	15664198
BRD7	BP75 \| CELTIX1 \| NAG4	bromodomain containing 7	-	HPRD	12489984
CBX5	HP1 \| HP1A	chromobox homolog 5 (HP1 alpha homolog, Drosophila)	Reconstituted Complex	BioGRID	11336697
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	HIST4H4 (H4) interacts with the CDKN1A promoter.	BIND	15765097
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	HIST4H4 (H4) interacts with the p21 promoter.	BIND	15710329
CIITA	C2TA \| CIITAIV \| MHC2TA \| NLRA	class II, major histocompatibility complex, transactivator	H4 interacts with p-MHC2TA.	BIND	15502823
CNR1	CANN6 \| CB-R \| CB1 \| CB1A \| CB1K5 \| CB1R \| CNR	cannabinoid receptor 1 (brain)	HIST4H4 (histone H4) interacts with the CNR1 promoter.	BIND	15688035
CTAG2	CAMEL \| ESO2 \| LAGE-1 \| LAGE-2b \| MGC138724 \| MGC3803	cancer/testis antigen 2	HIST4H4 (H4) interacts with the LAGE-1 (CTAG2) promoter.	BIND	15765097
DNTTIP2	ERBP \| FCF2 \| HSU15552 \| LPTS-RP2 \| MGC163494 \| RP4-561L24.1 \| TdIF2	deoxynucleotidyltransferase, terminal, interacting protein 2	-	HPRD,BioGRID	12786946
EP300	KAT3B \| p300	E1A binding protein p300	EP300 (p300) interacts with HIST4H4 (histone 4)	BIND	15834423
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	-	HPRD	10022855 \|11498536
GSTP1	DFN7 \| FAEES3 \| GST3 \| PI	glutathione S-transferase pi 1	HIST4H4 (H4) interacts with the GSTP1 promoter.	BIND	15765097
HDAC8	HDACL1 \| RPD3	histone deacetylase 8	-	HPRD	10926844
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	Biochemical Activity	BioGRID	12590135
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	HIST4H4 (Histone 4) interacts with the TCF1 (HNF-1) gene.	BIND	15616580
IFI6	6-16 \| FAM14C \| G1P3 \| IFI-6-16 \| IFI616	interferon, alpha-inducible protein 6	H4 interacts with p-G1P3.	BIND	15502823
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	Biochemical Activity	BioGRID	12015309
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	PCAF interacts with and acetylates H4. This interaction was modeled on a demonstrated interaction between PCAF and H4, both from unspecified species.	BIND	15992539
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Mdm2 interacts with H4.	BIND	15546622
MGMT	-	O-6-methylguanine-DNA methyltransferase	HIST4H4 (H4) interacts with the MGMT promoter.	BIND	15765097
PADI4	PAD \| PAD4 \| PADI5 \| PDI4 \| PDI5	peptidyl arginine deiminase, type IV	PAD4 interacts with and demethyliminates Histone H4.	BIND	15345777
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1 phosphorylates H4. This interaction was modeled on a demonstrated interaction between human PAK1 and H4 from an unspecified species.	BIND	15864311
PARP10	FLJ14464	poly (ADP-ribose) polymerase family, member 10	PARP10 poly(ADP-ribosyl)ates HIST4H4 (H4)	BIND	15674325
PGR	NR3C3 \| PR	progesterone receptor	H4 interacts with the PgRB promoter.	BIND	15019994
PGR	NR3C3 \| PR	progesterone receptor	H4 interacts with the PgRA promoter.	BIND	15019994
PRDM2	HUMHOXY1 \| KMT8 \| MTB-ZF \| RIZ \| RIZ1 \| RIZ2	PR domain containing 2, with ZNF domain	HIST4H4 (H4) interacts with the PRDM2 promoter.	BIND	15765097
PSCA	PRO232	prostate stem cell antigen	HIST4H4 (H4) interacts with the PSCA promoter.	BIND	15765097
RAD51L1	MGC34245 \| R51H2 \| RAD51B \| REC2 \| hREC2	RAD51-like 1 (S. cerevisiae)	RAD51B interacts with H4.	BIND	14595808
RARB	HAP \| NR1B2 \| RRB2	retinoic acid receptor, beta	Acetylated HIST4H4 (histone 4) interacts with RARB (RAR-beta-2) gene promoter sequences.	BIND	15688037
SAP30	-	Sin3A-associated protein, 30kDa	-	HPRD	9651585
SETDB1	ESET \| KG1T \| KIAA0067 \| KMT1E	SET domain, bifurcated 1	Reconstituted Complex	BioGRID	11959841
SIRT1	SIR2L1	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	SirT1 interacts with and deacetylates H4.	BIND	15469825
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	H4 interacts with the pS2 promoter.	BIND	15019994
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	Histone H4 interacts with the pS2 promoter.	BIND	15345777

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS	140	100	All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS	116	81	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION	89	64	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	122	80	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	64	43	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I PROMOTER OPENING	62	49	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION	86	62	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS	73	57	All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS	83	63	All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS	48	40	All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE	75	57	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN	228	114	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 DN	120	71	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
DUAN PRDM5 TARGETS	79	52	All SZGR 2.0 genes in this pathway

Gene Page: HIST4H4