Gene Page: CCR5

Summary ?
GeneID1234
SymbolCCR5
SynonymsCC-CKR-5|CCCKR5|CCR-5|CD195|CKR-5|CKR5|CMKBR5|IDDM22
DescriptionC-C motif chemokine receptor 5 (gene/pseudogene)
ReferenceMIM:601373|HGNC:HGNC:1606|HPRD:03223|
Gene typeprotein-coding
Map location3p21.31
Pascal p-value0.648
Fetal beta-0.907

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4775 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIDA12421915 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI12421915 |15001559 
GO:0004435phosphoinositide phospholipase C activityTAS8663314 
GO:0016493C-C chemokine receptor activityIEA-
GO:0016493C-C chemokine receptor activityNAS8639485 
GO:0015026coreceptor activityTAS10469138 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007204elevation of cytosolic calcium ion concentrationTAS10201901 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayTAS10393923 
GO:0007267cell-cell signalingTAS10679098 
GO:0006968cellular defense responseTAS10201901 
GO:0007165signal transductionIEA-
GO:0006955immune responseTAS8639485 
GO:0006954inflammatory responseTAS8639485 
GO:0006935chemotaxisTAS10741397 
GO:0019059initiation of viral infectionEXP12091904 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS10415069 
GO:0005768endosomeTAS10679098 
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneIDA11278962 
GO:0005886plasma membraneIEA-
GO:0005886plasma membraneTAS10201901 
GO:0005887integral to plasma membraneTAS10393923 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AFPFETA | HPAFPalpha-fetoprotein-HPRD,BioGRID12176010 
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID12065593 
CCL11MGC22554 | SCYA11chemokine (C-C motif) ligand 11-HPRD11264152 
CCL13CKb10 | MCP-4 | MGC17134 | NCC-1 | NCC1 | SCYA13 | SCYL1chemokine (C-C motif) ligand 13-HPRD10477718 
CCL14CC-1 | CC-3 | CKb1 | HCC-1 | HCC-3 | MCIF | NCC-2 | NCC2 | SCYA14 | SCYL2 | SY14chemokine (C-C motif) ligand 14-HPRD,BioGRID11085751 
CCL16CKb12 | HCC-4 | ILINCK | LCC-1 | LEC | LMC | MGC117051 | Mtn-1 | NCC-4 | NCC4 | SCYA16 | SCYL4chemokine (C-C motif) ligand 16-HPRD,BioGRID11470772 
CCL2GDCF-2 | HC11 | HSMCR30 | MCAF | MCP-1 | MCP1 | MGC9434 | SCYA2 | SMC-CFchemokine (C-C motif) ligand 2-HPRD10477718 
CCL3G0S19-1 | LD78ALPHA | MIP-1-alpha | MIP1A | SCYA3chemokine (C-C motif) ligand 3-HPRD,BioGRID11700073 
CCL3L1464.2 | D17S1718 | G0S19-2 | LD78 | LD78BETA | MGC104178 | MGC12815 | MGC182017 | MIP1AP | SCYA3L | SCYA3L1chemokine (C-C motif) ligand 3-like 1-HPRD,BioGRID11449371 |11734558 
CCL3L3464.2 | D17S1718 | LD78 | LD78BETA | MGC12815 | SCYA3L | SCYA3L1chemokine (C-C motif) ligand 3-like 3-HPRD10364178 |11734558 
CCL4ACT2 | AT744.1 | G-26 | LAG1 | MGC104418 | MGC126025 | MGC126026 | MIP-1-beta | MIP1B | MIP1B1 | SCYA2 | SCYA4chemokine (C-C motif) ligand 4-HPRD12427015 
CCL5D17S136E | MGC17164 | RANTES | SCYA5 | SISd | TCP228chemokine (C-C motif) ligand 5-HPRD8663314 |9289016 
|11116158 |14637022 
CCL5D17S136E | MGC17164 | RANTES | SCYA5 | SISd | TCP228chemokine (C-C motif) ligand 5Affinity Capture-Western
Reconstituted Complex		BioGRID11116158 |11449371 
|14637022 
CCL7FIC | MARC | MCP-3 | MCP3 | MGC138463 | MGC138465 | NC28 | SCYA6 | SCYA7chemokine (C-C motif) ligand 7-HPRD10477718 
CCL8HC14 | MCP-2 | MCP2 | SCYA10 | SCYA8chemokine (C-C motif) ligand 8-HPRD,BioGRID9468473 |10477718 
CCR2CC-CKR-2 | CCR2A | CCR2B | CD192 | CKR2 | CKR2A | CKR2B | CMKBR2 | MCP-1-Rchemokine (C-C motif) receptor 2-HPRD11350939 
CD4CD4mutCD4 molecule-HPRD,BioGRID10816381 
CXCR4CD184 | D2S201E | FB22 | HM89 | HSY3RR | LAP3 | LCR1 | LESTR | NPY3R | NPYR | NPYRL | NPYY3R | WHIMchemokine (C-X-C motif) receptor 4-HPRD,BioGRID12429730 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD11591716 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)Affinity Capture-WesternBioGRID11278738 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD11591716 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Affinity Capture-WesternBioGRID11350939 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID10384144 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD9446638 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Affinity Capture-WesternBioGRID11350939 
STAT5BSTAT5signal transducer and activator of transcription 5BAffinity Capture-WesternBioGRID11350939 
TXKBTKL | MGC22473 | PSCTK5 | PTK4 | RLK | TKLTXK tyrosine kinase-HPRD11859127 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
BIOCARTA TCAPOPTOSIS PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA NO2IL12 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY 2016All SZGR 2.0 genes in this pathway
BIOCARTA NKT PATHWAY 2921All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 5727All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME EARLY PHASE OF HIV LIFE CYCLE 218All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456228All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 11878All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 4423All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 5027All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE UP 3829All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 5030All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
ROETH TERT TARGETS DN 87All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 7748All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA HP UP 4926All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP 9564All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 7355All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 13484All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING NOT VIA ATM UP 6229All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN 4125All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS UP 2315All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 4430All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS AND CYCLIC RGD 2115All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 3325All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway