Gene Page: COL4A4

Summary
GeneID  1286
Symbol  COL4A4
Synonyms  CA44
Description  collagen, type IV, alpha 4
See related  HGNC:2206|MIM:120131|Ensembl:ENSG00000081052|HPRD:00360|
Locus tag  -
Gene type  protein-coding
Map location  2q35-q37
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AOC30.710.80
C7orf580.710.68
TBX180.680.75
FAM129A0.670.77
GJA50.660.71
LAMA20.640.71
CYP1B10.610.76
MYOF0.610.70
COL14A10.590.76
ITGA10.590.57
Top 10 negatively co-expressed genes
SNHG12-0.29-0.50
RPL17P20-0.27-0.46
RPS21-0.27-0.53
RPL31-0.26-0.51
RPS27A-0.26-0.55
RPL26-0.26-0.51
CHMP4A-0.26-0.34
RPL37-0.26-0.52
RPL34-0.25-0.52
RPL23A-0.25-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0005201extracellular matrix structural constituentISS-
GO:0005201extracellular matrix structural constituentTAS8253711 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042062long-term strengthening of neuromuscular junctionIDASynap (GO term level: 13)2211832 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005581collagenIEA-
GO:0005587collagen type IVIDA7523402 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANTXR2CMG-2 | CMG2 | FLJ31074 | ISH | JHF | MGC111533 | MGC45856anthrax toxin receptor 2-HPRD11683410 
CD93C1QR1 | C1qR(P) | C1qRP | CDw93 | MXRA4 | dJ737E23.1CD93 molecule-HPRD9136074 
DCNCSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1Bdecorin-HPRD10382266 
FBLN2-fibulin 2-HPRD,BioGRID7500359 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD3997552 
HABP2FSAP | HABP | HGFAL | PHBPhyaluronan binding protein 2-HPRD,BioGRID1724753 
MATN2-matrilin 2-HPRD12180907 
MMP9CLG4B | GELB | MMP-9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)-HPRD,BioGRID9878537 
OSMMGC20461oncostatin M-HPRD,BioGRID11711546 
SAA1MGC111216 | PIG4 | SAA | TP53I4serum amyloid A1-HPRD8995276 
SERPINE2GDN | PI7 | PN1 | PNIserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2-HPRD,BioGRID8006028 
TGFBIBIGH3 | CDB1 | CDG2 | CDGG1 | CSD | CSD1 | CSD2 | CSD3 | EBMD | LCD1transforming growth factor, beta-induced, 68kDa-HPRD11867580 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ECM_RECEPTOR_INTERACTION 8453All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
BIOCARTA_AMI_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_ACE2_PATHWAY 137All SZGR genes in this pathway
BIOCARTA_INTRINSIC_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_PLATELETAPP_PATHWAY 1410All SZGR genes in this pathway
BIOCARTA_VITCB_PATHWAY 116All SZGR genes in this pathway
PID_INTEGRIN1_PATHWAY 6644All SZGR genes in this pathway
PID_INTEGRIN3_PATHWAY 4325All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY 4629All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 8742All SZGR genes in this pathway
REACTOME_COLLAGEN_FORMATION 5831All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM1_INTERACTIONS 3927All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
ZHANG_GATA6_TARGETS_DN 6446All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3 3421All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K27ME3 206108All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3 12683All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
NABA_COLLAGENS 4426All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_BASEMENT_MEMBRANES 4022All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-150109210991A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-23443344401A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-298288m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-299-5p435243581Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-323443344391Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-410457945851Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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