Gene Page: TTC32
Summary ?
| GeneID | 130502 |
| Symbol | TTC32 |
| Synonyms | - |
| Description | tetratricopeptide repeat domain 32 |
| Reference | HGNC:HGNC:32954|Ensembl:ENSG00000183891|HPRD:17296|Vega:OTTHUMG00000151776 |
| Gene type | protein-coding |
| Map location | 2p24.1 |
| Pascal p-value | 0.211 |
| Fetal beta | 0.109 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00745248 | 2 | 20101788 | TTC32 | 9.56E-9 | -0.01 | 4.24E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs62109397 | 2 | 20082172 | TTC32 | ENSG00000183891.5 | 2.853E-14 | 0 | 19575 | gtex_brain_ba24 |
| rs62109398 | 2 | 20082748 | TTC32 | ENSG00000183891.5 | 3.115E-14 | 0 | 18999 | gtex_brain_ba24 |
| rs13421472 | 2 | 20082812 | TTC32 | ENSG00000183891.5 | 3.115E-14 | 0 | 18935 | gtex_brain_ba24 |
| rs62109399 | 2 | 20083373 | TTC32 | ENSG00000183891.5 | 3.115E-14 | 0 | 18374 | gtex_brain_ba24 |
| rs7423003 | 2 | 20083421 | TTC32 | ENSG00000183891.5 | 1.031E-7 | 0 | 18326 | gtex_brain_ba24 |
| rs10204428 | 2 | 20084133 | TTC32 | ENSG00000183891.5 | 3.418E-8 | 0 | 17614 | gtex_brain_ba24 |
| rs10168217 | 2 | 20084387 | TTC32 | ENSG00000183891.5 | 5.743E-7 | 0 | 17360 | gtex_brain_ba24 |
| rs12622453 | 2 | 20084639 | TTC32 | ENSG00000183891.5 | 3.042E-7 | 0 | 17108 | gtex_brain_ba24 |
| rs10171948 | 2 | 20085769 | TTC32 | ENSG00000183891.5 | 9.564E-8 | 0 | 15978 | gtex_brain_ba24 |
| rs13419597 | 2 | 20086391 | TTC32 | ENSG00000183891.5 | 3.809E-7 | 0 | 15356 | gtex_brain_ba24 |
| rs13432782 | 2 | 20086462 | TTC32 | ENSG00000183891.5 | 1.003E-7 | 0 | 15285 | gtex_brain_ba24 |
| rs12617761 | 2 | 20088018 | TTC32 | ENSG00000183891.5 | 3.3E-15 | 0 | 13729 | gtex_brain_ba24 |
| rs10211008 | 2 | 20088403 | TTC32 | ENSG00000183891.5 | 2.996E-8 | 0 | 13344 | gtex_brain_ba24 |
| rs80296077 | 2 | 20089000 | TTC32 | ENSG00000183891.5 | 7.719E-16 | 0 | 12747 | gtex_brain_ba24 |
| rs13385093 | 2 | 20089411 | TTC32 | ENSG00000183891.5 | 6.89E-7 | 0 | 12336 | gtex_brain_ba24 |
| rs35957485 | 2 | 20090677 | TTC32 | ENSG00000183891.5 | 5.877E-17 | 0 | 11070 | gtex_brain_ba24 |
| rs16987206 | 2 | 20090739 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | 11008 | gtex_brain_ba24 |
| rs11887799 | 2 | 20091399 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | 10348 | gtex_brain_ba24 |
| rs11888045 | 2 | 20091890 | TTC32 | ENSG00000183891.5 | 6.129E-17 | 0 | 9857 | gtex_brain_ba24 |
| rs11889206 | 2 | 20092032 | TTC32 | ENSG00000183891.5 | 6.167E-17 | 0 | 9715 | gtex_brain_ba24 |
| rs7563410 | 2 | 20096936 | TTC32 | ENSG00000183891.5 | 6.973E-17 | 0 | 4811 | gtex_brain_ba24 |
| rs12328613 | 2 | 20097874 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | 3873 | gtex_brain_ba24 |
| rs7572167 | 2 | 20100988 | TTC32 | ENSG00000183891.5 | 9.742E-17 | 0 | 759 | gtex_brain_ba24 |
| rs2304589 | 2 | 20101487 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | 260 | gtex_brain_ba24 |
| rs2304588 | 2 | 20101717 | TTC32 | ENSG00000183891.5 | 6.973E-17 | 0 | 30 | gtex_brain_ba24 |
| rs2278528 | 2 | 20101832 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | -85 | gtex_brain_ba24 |
| rs7594214 | 2 | 20106369 | TTC32 | ENSG00000183891.5 | 6.973E-17 | 0 | -4622 | gtex_brain_ba24 |
| rs28742930 | 2 | 20106598 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | -4851 | gtex_brain_ba24 |
| rs62109404 | 2 | 20106942 | TTC32 | ENSG00000183891.5 | 6.973E-17 | 0 | -5195 | gtex_brain_ba24 |
| rs10175486 | 2 | 20109061 | TTC32 | ENSG00000183891.5 | 1.77E-7 | 0 | -7314 | gtex_brain_ba24 |
| rs62109406 | 2 | 20115111 | TTC32 | ENSG00000183891.5 | 3.992E-16 | 0 | -13364 | gtex_brain_ba24 |
| rs28502265 | 2 | 20130145 | TTC32 | ENSG00000183891.5 | 7.476E-16 | 0 | -28398 | gtex_brain_ba24 |
| rs12052274 | 2 | 20131672 | TTC32 | ENSG00000183891.5 | 1.034E-12 | 0 | -29925 | gtex_brain_ba24 |
| rs6755153 | 2 | 20136292 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -34545 | gtex_brain_ba24 |
| rs2293671 | 2 | 20137864 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -36117 | gtex_brain_ba24 |
| rs71990395 | 2 | 20142309 | TTC32 | ENSG00000183891.5 | 3.884E-12 | 0 | -40562 | gtex_brain_ba24 |
| rs10208878 | 2 | 20142744 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -40997 | gtex_brain_ba24 |
| rs11096632 | 2 | 20144372 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -42625 | gtex_brain_ba24 |
| rs6707471 | 2 | 20146844 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -45097 | gtex_brain_ba24 |
| rs62109413 | 2 | 20152116 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -50369 | gtex_brain_ba24 |
| rs62109415 | 2 | 20154473 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -52726 | gtex_brain_ba24 |
| rs62109416 | 2 | 20154959 | TTC32 | ENSG00000183891.5 | 8.796E-16 | 0 | -53212 | gtex_brain_ba24 |
| rs6719397 | 2 | 20155545 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -53798 | gtex_brain_ba24 |
| rs7589478 | 2 | 20157495 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -55748 | gtex_brain_ba24 |
| rs12620863 | 2 | 20158464 | TTC32 | ENSG00000183891.5 | 5.967E-13 | 0 | -56717 | gtex_brain_ba24 |
| rs10169398 | 2 | 20160209 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -58462 | gtex_brain_ba24 |
| rs12613209 | 2 | 20162971 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -61224 | gtex_brain_ba24 |
| rs62109418 | 2 | 20164291 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -62544 | gtex_brain_ba24 |
| rs10175095 | 2 | 20164683 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -62936 | gtex_brain_ba24 |
| rs62109419 | 2 | 20167001 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -65254 | gtex_brain_ba24 |
| rs28477921 | 2 | 20171987 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -70240 | gtex_brain_ba24 |
| rs13415707 | 2 | 20173673 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -71926 | gtex_brain_ba24 |
| rs16987265 | 2 | 20174902 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -73155 | gtex_brain_ba24 |
| rs10197385 | 2 | 20176574 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -74827 | gtex_brain_ba24 |
| rs1381817 | 2 | 20179220 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -77473 | gtex_brain_ba24 |
| rs62109420 | 2 | 20185765 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -84018 | gtex_brain_ba24 |
| rs62109421 | 2 | 20186200 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -84453 | gtex_brain_ba24 |
| rs1060742 | 2 | 20189015 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -87268 | gtex_brain_ba24 |
| rs10495701 | 2 | 20197851 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -96104 | gtex_brain_ba24 |
| rs55977150 | 2 | 20201922 | TTC32 | ENSG00000183891.5 | 8.735E-16 | 0 | -100175 | gtex_brain_ba24 |
| rs10856792 | 2 | 20208412 | TTC32 | ENSG00000183891.5 | 4.684E-7 | 0 | -106665 | gtex_brain_ba24 |
| rs2006707 | 2 | 20209618 | TTC32 | ENSG00000183891.5 | 2.537E-9 | 0 | -107871 | gtex_brain_ba24 |
| rs113917580 | 2 | 20212700 | TTC32 | ENSG00000183891.5 | 1.474E-8 | 0 | -110953 | gtex_brain_ba24 |
| rs62109425 | 2 | 20212942 | TTC32 | ENSG00000183891.5 | 1.529E-8 | 0 | -111195 | gtex_brain_ba24 |
| rs62109426 | 2 | 20213439 | TTC32 | ENSG00000183891.5 | 6.51E-15 | 0 | -111692 | gtex_brain_ba24 |
| rs1147110 | 2 | 20214880 | TTC32 | ENSG00000183891.5 | 3.754E-8 | 0 | -113133 | gtex_brain_ba24 |
| rs62109397 | 2 | 20082172 | TTC32 | ENSG00000183891.5 | 1.724E-7 | 0 | 19575 | gtex_brain_putamen_basal |
| rs62109398 | 2 | 20082748 | TTC32 | ENSG00000183891.5 | 1.674E-7 | 0 | 18999 | gtex_brain_putamen_basal |
| rs13421472 | 2 | 20082812 | TTC32 | ENSG00000183891.5 | 1.674E-7 | 0 | 18935 | gtex_brain_putamen_basal |
| rs62109399 | 2 | 20083373 | TTC32 | ENSG00000183891.5 | 1.674E-7 | 0 | 18374 | gtex_brain_putamen_basal |
| rs12617761 | 2 | 20088018 | TTC32 | ENSG00000183891.5 | 1.666E-7 | 0 | 13729 | gtex_brain_putamen_basal |
| rs80296077 | 2 | 20089000 | TTC32 | ENSG00000183891.5 | 1.655E-7 | 0 | 12747 | gtex_brain_putamen_basal |
| rs35957485 | 2 | 20090677 | TTC32 | ENSG00000183891.5 | 3.036E-9 | 0 | 11070 | gtex_brain_putamen_basal |
| rs11888045 | 2 | 20091890 | TTC32 | ENSG00000183891.5 | 3.009E-9 | 0 | 9857 | gtex_brain_putamen_basal |
| rs11889206 | 2 | 20092032 | TTC32 | ENSG00000183891.5 | 3.002E-9 | 0 | 9715 | gtex_brain_putamen_basal |
| rs7563410 | 2 | 20096936 | TTC32 | ENSG00000183891.5 | 2.894E-9 | 0 | 4811 | gtex_brain_putamen_basal |
| rs7572167 | 2 | 20100988 | TTC32 | ENSG00000183891.5 | 1.961E-9 | 0 | 759 | gtex_brain_putamen_basal |
| rs2304588 | 2 | 20101717 | TTC32 | ENSG00000183891.5 | 2.894E-9 | 0 | 30 | gtex_brain_putamen_basal |
| rs7594214 | 2 | 20106369 | TTC32 | ENSG00000183891.5 | 2.894E-9 | 0 | -4622 | gtex_brain_putamen_basal |
| rs62109404 | 2 | 20106942 | TTC32 | ENSG00000183891.5 | 2.894E-9 | 0 | -5195 | gtex_brain_putamen_basal |
| rs62109406 | 2 | 20115111 | TTC32 | ENSG00000183891.5 | 7.133E-9 | 0 | -13364 | gtex_brain_putamen_basal |
| rs28502265 | 2 | 20130145 | TTC32 | ENSG00000183891.5 | 8.775E-9 | 0 | -28398 | gtex_brain_putamen_basal |
| rs12052274 | 2 | 20131672 | TTC32 | ENSG00000183891.5 | 7.097E-9 | 0 | -29925 | gtex_brain_putamen_basal |
| rs6755153 | 2 | 20136292 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -34545 | gtex_brain_putamen_basal |
| rs2293671 | 2 | 20137864 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -36117 | gtex_brain_putamen_basal |
| rs71990395 | 2 | 20142309 | TTC32 | ENSG00000183891.5 | 1.523E-8 | 0 | -40562 | gtex_brain_putamen_basal |
| rs10208878 | 2 | 20142744 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -40997 | gtex_brain_putamen_basal |
| rs11096632 | 2 | 20144372 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -42625 | gtex_brain_putamen_basal |
| rs6707471 | 2 | 20146844 | TTC32 | ENSG00000183891.5 | 9.764E-9 | 0 | -45097 | gtex_brain_putamen_basal |
| rs62109413 | 2 | 20152116 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -50369 | gtex_brain_putamen_basal |
| rs62109415 | 2 | 20154473 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -52726 | gtex_brain_putamen_basal |
| rs62109416 | 2 | 20154959 | TTC32 | ENSG00000183891.5 | 9.272E-9 | 0 | -53212 | gtex_brain_putamen_basal |
| rs6719397 | 2 | 20155545 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -53798 | gtex_brain_putamen_basal |
| rs7589478 | 2 | 20157495 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -55748 | gtex_brain_putamen_basal |
| rs12620863 | 2 | 20158464 | TTC32 | ENSG00000183891.5 | 3.823E-8 | 0 | -56717 | gtex_brain_putamen_basal |
| rs10169398 | 2 | 20160209 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -58462 | gtex_brain_putamen_basal |
| rs12613209 | 2 | 20162971 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -61224 | gtex_brain_putamen_basal |
| rs62109418 | 2 | 20164291 | TTC32 | ENSG00000183891.5 | 9.227E-9 | 0 | -62544 | gtex_brain_putamen_basal |
| rs10175095 | 2 | 20164683 | TTC32 | ENSG00000183891.5 | 9.227E-9 | 0 | -62936 | gtex_brain_putamen_basal |
| rs62109419 | 2 | 20167001 | TTC32 | ENSG00000183891.5 | 9.215E-9 | 0 | -65254 | gtex_brain_putamen_basal |
| rs28477921 | 2 | 20171987 | TTC32 | ENSG00000183891.5 | 9.227E-9 | 0 | -70240 | gtex_brain_putamen_basal |
| rs13415707 | 2 | 20173673 | TTC32 | ENSG00000183891.5 | 9.227E-9 | 0 | -71926 | gtex_brain_putamen_basal |
| rs16987265 | 2 | 20174902 | TTC32 | ENSG00000183891.5 | 9.227E-9 | 0 | -73155 | gtex_brain_putamen_basal |
| rs10197385 | 2 | 20176574 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -74827 | gtex_brain_putamen_basal |
| rs1381817 | 2 | 20179220 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -77473 | gtex_brain_putamen_basal |
| rs62109420 | 2 | 20185765 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -84018 | gtex_brain_putamen_basal |
| rs62109421 | 2 | 20186200 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -84453 | gtex_brain_putamen_basal |
| rs1060742 | 2 | 20189015 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -87268 | gtex_brain_putamen_basal |
| rs10495701 | 2 | 20197851 | TTC32 | ENSG00000183891.5 | 1.063E-8 | 0 | -96104 | gtex_brain_putamen_basal |
| rs55977150 | 2 | 20201922 | TTC32 | ENSG00000183891.5 | 9.233E-9 | 0 | -100175 | gtex_brain_putamen_basal |
| rs62109426 | 2 | 20213439 | TTC32 | ENSG00000183891.5 | 2.232E-7 | 0 | -111692 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |