Summary ?
GeneID131076
SymbolCCDC58
Synonyms-
Descriptioncoiled-coil domain containing 58
ReferenceHGNC:HGNC:31136|Ensembl:ENSG00000160124|HPRD:18548|Vega:OTTHUMG00000159490
Gene typeprotein-coding
Map location3q21.1
Pascal p-value0.416
Fetal beta-0.018
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg137130523122102218CCDC583.43E-8-0.021.02E-5DMG:Jaffe_2016
cg165325293122101951CCDC584.26E-8-0.021.18E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs11716910chr3121987618CCDC581310761.8E-5cis
rs3792288chr3121993431CCDC581310760.19cis
rs4678174chr3122000870CCDC581310760cis
rs10934581chr3122011153CCDC581310762.369E-6cis
rs7633800chr3122011664CCDC581310769.319E-7cis
rs7633667chr3122011725CCDC581310761.126E-6cis
rs17252533chr3122022206CCDC581310760cis
rs7616785chr3122072878CCDC581310763.242E-5cis
rs6807375chr3122082274CCDC581310761.335E-5cis
rs12488155chr3122082837CCDC581310761.169E-5cis
rs11932chr3122141134CCDC581310760.07cis
rs6438731chr3122180949CCDC581310763.849E-5cis
rs10934602chr3122223181CCDC581310760.04cis
rs6438737chr3122228973CCDC581310760.05cis
rs4485669chr3122234614CCDC581310763.419E-5cis
rs6810306chr3122248709CCDC581310767.661E-5cis
rs11716910chr3121987618CCDC581310760trans
rs4678174chr3122000870CCDC581310760.11trans
rs10934581chr3122011153CCDC581310764.092E-4trans
rs7633800chr3122011664CCDC581310761.751E-4trans
rs7633667chr3122011725CCDC581310762.095E-4trans
rs17252533chr3122022206CCDC581310760.08trans
rs7616785chr3122072878CCDC581310760trans
rs6807375chr3122082274CCDC581310760trans
rs12488155chr3122082837CCDC581310760trans
rs6438731chr3122180949CCDC581310760trans
rs4485669chr3122234614CCDC581310760trans
rs6810306chr3122248709CCDC581310760.01trans
rs1604454chr523945802CCDC581310760.03trans
rs6863680chr523996889CCDC581310760.02trans
rs10942018chr523997153CCDC581310760.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285181All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS DN 3818All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway