Gene Page: COMP

Summary ?
GeneID1311
SymbolCOMP
SynonymsEDM1|EPD1|MED|PSACH|THBS5
Descriptioncartilage oligomeric matrix protein
ReferenceMIM:600310|HGNC:HGNC:2227|Ensembl:ENSG00000105664|HPRD:02632|Vega:OTTHUMG00000169318
Gene typeprotein-coding
Map location19p13.1
Pascal p-value0.331
DMG1 (# studies)
eGeneCerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg099800581918898325COMP3.38E-4-0.4060.041DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs3761082chr1919249726COMP13110.18cis
rs4653163chr136627444COMP13110.04trans
rs12092846chr159940646COMP13110trans
rs13447530chr191983798COMP13110.01trans
rs6687849chr1175904808COMP13111.41E-5trans
rs2481653chr1176044120COMP13110trans
rs2502827chr1176044216COMP13119.982E-8trans
rs10913839chr1179593165COMP13110.09trans
rs3008613chr1222795768COMP13110.15trans
rs882011chr222711668COMP13119.828E-4trans
rs17028363chr241913161COMP13110trans
rs16829545chr2151977407COMP13114.03E-16trans
rs16841750chr2158288461COMP13113.43E-5trans
rs16863816chr2177292762COMP13110.03trans
rs7584986chr2184111432COMP13110.03trans
rs10183246chr2237187882COMP13113.137E-6trans
rs10195546chr2237187933COMP13111.114E-4trans
rs2322831chr34799093COMP13110.03trans
rs4685815chr34799947COMP13110.11trans
rs9810143chr35060209COMP13113.716E-9trans
rs6797307chr38601563COMP13114.634E-6trans
rs6807632chr3111395567COMP13110trans
rs917937chr3137411335COMP13110.06trans
rs6773248chr3174790333COMP13110.01trans
rs6797728chr3174790417COMP13110.01trans
rs5030115chr3186457331COMP13110.08trans
rs1996119chr3197531387COMP13114.925E-4trans
rs16868907chr419933369COMP13110.14trans
rs4575988chr419984925COMP13110.09trans
rs12642340chr435390674COMP13110.13trans
rs662007chr4125253160COMP13110.02trans
rs1608464chr4125318297COMP13110.16trans
rs17008119chr4125321425COMP13116.259E-4trans
rs7692715chr4125335209COMP13119.863E-5trans
rs6821203chr4189475342COMP13110.02trans
rs10474151chr584286402COMP13110.01trans
rs133604960COMP13110.01trans
rs16890367chr638078448COMP13111.077E-5trans
rs12706918chr780266147COMP13110.01trans
rs2299269chr795619376COMP13110.03trans
rs2166120chr7153120003COMP13110.1trans
rs6996695chr877540580COMP13111.49E-5trans
rs3118341chr925185518COMP13110.08trans
rs9406868chr925223372COMP13110.1trans
rs17263352chr9124811572COMP13110.17trans
rs2287296chr9132395244COMP13110.03trans
rs11005888chr1059421572COMP13110.14trans
rs17124813chr10110347464COMP13110.07trans
rs11215990chr11116407582COMP13110.17trans
rs7972699chr12105155290COMP13112.714E-6trans
rs7488439chr12105155814COMP13111.253E-7trans
rs17036489chr12105292283COMP13111.501E-7trans
rs890460chr12119644855COMP13110.07trans
rs11060407chr12130017919COMP13110.17trans
rs11060408chr12130018281COMP13110.15trans
rs457696chr1332581313COMP13111.431E-5trans
rs9566986chr1332595026COMP13117.987E-4trans
rs1530404chr1364207519COMP13110.07trans
rs17289777chr1364223062COMP13110.07trans
rs7337531chr13109611085COMP13110.11trans
rs177369chr1473760441COMP13110trans
rs1629937chr1477059671COMP13110.04trans
rs17104720chr1477127308COMP13110.01trans
rs8009751chr1483313138COMP13110.06trans
rs16955618chr1529937543COMP13112.098E-25trans
rs2045264chr1594793620COMP13110.2trans
rs1420984chr1651408733COMP13110.01trans
rs16968252chr1731692447COMP13110.15trans
rs8068272chr1749952680COMP13110.17trans
rs17820517chr1753980462COMP13110.01trans
rs17758736chr1754035819COMP13110.02trans
rs17823633chr1768851458COMP13112.524E-4trans
rs755768chr1775023387COMP13110.02trans
rs11873184chr181584081COMP13110.06trans
rs17681878chr1834767223COMP13110.14trans
rs17071138chr1861143907COMP13110.1trans
rs6032295chr2044178138COMP13110.02trans
rs6019060chr2046965832COMP13110.01trans
rs749043chr2046995700COMP13119.253E-6trans
rs1041786chr2122617710COMP13110.01trans
rs7278206chr2128171971COMP13110.18trans
rs5992807chr2218210821COMP13110.07trans
rs7288523chr2250082517COMP13110.15trans
rs16990575chrX32691327COMP13113.93E-4trans
rs16993189chrX144666166COMP13110trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION 8453All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP 6938All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN 7442All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 9264All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 11471All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER B 4822All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP 4936All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM DN 1914All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
LY AGING MIDDLE UP 1411All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN LUNG DN 3722All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 5935All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
LY AGING OLD UP 75All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE 6440All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN 8344All SZGR 2.0 genes in this pathway
NABA ECM GLYCOPROTEINS 19699All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275148All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway