Gene Page: PACRGL
Summary ?
| GeneID | 133015 |
| Symbol | PACRGL |
| Synonyms | C4orf28 |
| Description | PARK2 co-regulated like |
| Reference | HGNC:HGNC:28442|Ensembl:ENSG00000163138|HPRD:14537|Vega:OTTHUMG00000128550 |
| Gene type | protein-coding |
| Map location | 4p15.31 |
| Pascal p-value | 0.036 |
| Fetal beta | 0.383 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16869851 | chr4 | 20690056 | PACRGL | 133015 | 0.07 | cis | ||
| rs62410091 | 4 | 20683956 | PACRGL | ENSG00000163138.14 | 4.869E-7 | 0 | -13949 | gtex_brain_ba24 |
| rs55874299 | 4 | 20693554 | PACRGL | ENSG00000163138.14 | 1.045E-6 | 0 | -4351 | gtex_brain_ba24 |
| rs6857386 | 4 | 20694725 | PACRGL | ENSG00000163138.14 | 1.025E-7 | 0 | -3180 | gtex_brain_ba24 |
| rs964019 | 4 | 20704056 | PACRGL | ENSG00000163138.14 | 3.37E-8 | 0 | 6151 | gtex_brain_ba24 |
| rs11936560 | 4 | 20704538 | PACRGL | ENSG00000163138.14 | 1.029E-7 | 0 | 6633 | gtex_brain_ba24 |
| rs11940062 | 4 | 20705599 | PACRGL | ENSG00000163138.14 | 1.029E-7 | 0 | 7694 | gtex_brain_ba24 |
| rs397798377 | 4 | 20709238 | PACRGL | ENSG00000163138.14 | 1.934E-7 | 0 | 11333 | gtex_brain_ba24 |
| rs10031524 | 4 | 20710325 | PACRGL | ENSG00000163138.14 | 6.154E-8 | 0 | 12420 | gtex_brain_ba24 |
| rs3764965 | 4 | 20714653 | PACRGL | ENSG00000163138.14 | 5.252E-7 | 0 | 16748 | gtex_brain_ba24 |
| rs1820505 | 4 | 20717392 | PACRGL | ENSG00000163138.14 | 6.156E-8 | 0 | 19487 | gtex_brain_ba24 |
| rs4577580 | 4 | 20720532 | PACRGL | ENSG00000163138.14 | 2.2E-7 | 0 | 22627 | gtex_brain_ba24 |
| rs7668797 | 4 | 20722379 | PACRGL | ENSG00000163138.14 | 8.546E-8 | 0 | 24474 | gtex_brain_ba24 |
| rs6447971 | 4 | 20724027 | PACRGL | ENSG00000163138.14 | 9.306E-7 | 0 | 26122 | gtex_brain_ba24 |
| rs6447972 | 4 | 20724371 | PACRGL | ENSG00000163138.14 | 6.224E-8 | 0 | 26466 | gtex_brain_ba24 |
| rs7688592 | 4 | 20724731 | PACRGL | ENSG00000163138.14 | 1.045E-7 | 0 | 26826 | gtex_brain_ba24 |
| rs6447973 | 4 | 20726772 | PACRGL | ENSG00000163138.14 | 1.043E-7 | 0 | 28867 | gtex_brain_ba24 |
| rs59189281 | 4 | 20729275 | PACRGL | ENSG00000163138.14 | 1.798E-8 | 0 | 31370 | gtex_brain_ba24 |
| rs2114474 | 4 | 20733270 | PACRGL | ENSG00000163138.14 | 1.773E-8 | 0 | 35365 | gtex_brain_ba24 |
| rs398092219 | 4 | 20733708 | PACRGL | ENSG00000163138.14 | 3.321E-9 | 0 | 35803 | gtex_brain_ba24 |
| rs6811933 | 4 | 20734176 | PACRGL | ENSG00000163138.14 | 2.21E-8 | 0 | 36271 | gtex_brain_ba24 |
| rs11436210 | 4 | 20738921 | PACRGL | ENSG00000163138.14 | 2.27E-8 | 0 | 41016 | gtex_brain_ba24 |
| rs6858843 | 4 | 20739530 | PACRGL | ENSG00000163138.14 | 1.627E-8 | 0 | 41625 | gtex_brain_ba24 |
| rs61428210 | 4 | 20739905 | PACRGL | ENSG00000163138.14 | 3.54E-8 | 0 | 42000 | gtex_brain_ba24 |
| rs7660187 | 4 | 20740426 | PACRGL | ENSG00000163138.14 | 1.847E-8 | 0 | 42521 | gtex_brain_ba24 |
| rs2322687 | 4 | 20741823 | PACRGL | ENSG00000163138.14 | 2.1E-7 | 0 | 43918 | gtex_brain_ba24 |
| rs10938803 | 4 | 20749299 | PACRGL | ENSG00000163138.14 | 1.855E-7 | 0 | 51394 | gtex_brain_ba24 |
| rs201477394 | 4 | 20750180 | PACRGL | ENSG00000163138.14 | 4.107E-7 | 0 | 52275 | gtex_brain_ba24 |
| rs7663837 | 4 | 20752852 | PACRGL | ENSG00000163138.14 | 1.539E-7 | 0 | 54947 | gtex_brain_ba24 |
| rs7689421 | 4 | 20755240 | PACRGL | ENSG00000163138.14 | 1.467E-7 | 0 | 57335 | gtex_brain_ba24 |
| rs3816874 | 4 | 20756490 | PACRGL | ENSG00000163138.14 | 3.386E-8 | 0 | 58585 | gtex_brain_ba24 |
| rs7694208 | 4 | 20759614 | PACRGL | ENSG00000163138.14 | 1.497E-7 | 0 | 61709 | gtex_brain_ba24 |
| rs5856577 | 4 | 20761266 | PACRGL | ENSG00000163138.14 | 7.314E-8 | 0 | 63361 | gtex_brain_ba24 |
| rs61790717 | 4 | 20634101 | PACRGL | ENSG00000163138.14 | 1.267E-6 | 0 | -63804 | gtex_brain_putamen_basal |
| rs61790719 | 4 | 20634902 | PACRGL | ENSG00000163138.14 | 1.83E-6 | 0 | -63003 | gtex_brain_putamen_basal |
| rs61790721 | 4 | 20643729 | PACRGL | ENSG00000163138.14 | 2.471E-6 | 0 | -54176 | gtex_brain_putamen_basal |
| rs17621831 | 4 | 20645380 | PACRGL | ENSG00000163138.14 | 1.091E-6 | 0 | -52525 | gtex_brain_putamen_basal |
| rs61790723 | 4 | 20648369 | PACRGL | ENSG00000163138.14 | 1.091E-6 | 0 | -49536 | gtex_brain_putamen_basal |
| rs55735098 | 4 | 20653762 | PACRGL | ENSG00000163138.14 | 1.091E-6 | 0 | -44143 | gtex_brain_putamen_basal |
| rs1080125 | 4 | 20654985 | PACRGL | ENSG00000163138.14 | 2.177E-6 | 0 | -42920 | gtex_brain_putamen_basal |
| rs77976884 | 4 | 20655185 | PACRGL | ENSG00000163138.14 | 2.177E-6 | 0 | -42720 | gtex_brain_putamen_basal |
| rs61790750 | 4 | 20657954 | PACRGL | ENSG00000163138.14 | 1.091E-6 | 0 | -39951 | gtex_brain_putamen_basal |
| rs6447969 | 4 | 20668542 | PACRGL | ENSG00000163138.14 | 5.323E-7 | 0 | -29363 | gtex_brain_putamen_basal |
| rs59687189 | 4 | 20669728 | PACRGL | ENSG00000163138.14 | 8.295E-8 | 0 | -28177 | gtex_brain_putamen_basal |
| rs62410066 | 4 | 20670285 | PACRGL | ENSG00000163138.14 | 8.295E-8 | 0 | -27620 | gtex_brain_putamen_basal |
| rs10805218 | 4 | 20674741 | PACRGL | ENSG00000163138.14 | 8.295E-8 | 0 | -23164 | gtex_brain_putamen_basal |
| rs55863541 | 4 | 20685378 | PACRGL | ENSG00000163138.14 | 1.086E-6 | 0 | -12527 | gtex_brain_putamen_basal |
| rs1365580 | 4 | 20687802 | PACRGL | ENSG00000163138.14 | 4.248E-8 | 0 | -10103 | gtex_brain_putamen_basal |
| rs62410096 | 4 | 20693070 | PACRGL | ENSG00000163138.14 | 4.323E-8 | 0 | -4835 | gtex_brain_putamen_basal |
| rs55733615 | 4 | 20694541 | PACRGL | ENSG00000163138.14 | 1.085E-6 | 0 | -3364 | gtex_brain_putamen_basal |
| rs6857386 | 4 | 20694725 | PACRGL | ENSG00000163138.14 | 3.533E-7 | 0 | -3180 | gtex_brain_putamen_basal |
| rs12503714 | 4 | 20696924 | PACRGL | ENSG00000163138.14 | 4.252E-8 | 0 | -981 | gtex_brain_putamen_basal |
| rs56267013 | 4 | 20700298 | PACRGL | ENSG00000163138.14 | 4.26E-8 | 0 | 2393 | gtex_brain_putamen_basal |
| rs76783569 | 4 | 20702164 | PACRGL | ENSG00000163138.14 | 4.323E-8 | 0 | 4259 | gtex_brain_putamen_basal |
| rs964019 | 4 | 20704056 | PACRGL | ENSG00000163138.14 | 1.156E-6 | 0 | 6151 | gtex_brain_putamen_basal |
| rs11936560 | 4 | 20704538 | PACRGL | ENSG00000163138.14 | 7.436E-7 | 0 | 6633 | gtex_brain_putamen_basal |
| rs78014153 | 4 | 20705183 | PACRGL | ENSG00000163138.14 | 1.088E-6 | 0 | 7278 | gtex_brain_putamen_basal |
| rs11940062 | 4 | 20705599 | PACRGL | ENSG00000163138.14 | 7.434E-7 | 0 | 7694 | gtex_brain_putamen_basal |
| rs397798377 | 4 | 20709238 | PACRGL | ENSG00000163138.14 | 7.468E-7 | 0 | 11333 | gtex_brain_putamen_basal |
| rs10031524 | 4 | 20710325 | PACRGL | ENSG00000163138.14 | 5.009E-7 | 0 | 12420 | gtex_brain_putamen_basal |
| rs1820505 | 4 | 20717392 | PACRGL | ENSG00000163138.14 | 5.026E-7 | 0 | 19487 | gtex_brain_putamen_basal |
| rs4577580 | 4 | 20720532 | PACRGL | ENSG00000163138.14 | 1.379E-6 | 0 | 22627 | gtex_brain_putamen_basal |
| rs7668797 | 4 | 20722379 | PACRGL | ENSG00000163138.14 | 6.28E-7 | 0 | 24474 | gtex_brain_putamen_basal |
| rs62410131 | 4 | 20722827 | PACRGL | ENSG00000163138.14 | 1.217E-6 | 0 | 24922 | gtex_brain_putamen_basal |
| rs6447971 | 4 | 20724027 | PACRGL | ENSG00000163138.14 | 6.981E-7 | 0 | 26122 | gtex_brain_putamen_basal |
| rs6447972 | 4 | 20724371 | PACRGL | ENSG00000163138.14 | 5.029E-7 | 0 | 26466 | gtex_brain_putamen_basal |
| rs7688592 | 4 | 20724731 | PACRGL | ENSG00000163138.14 | 7.485E-7 | 0 | 26826 | gtex_brain_putamen_basal |
| rs6447973 | 4 | 20726772 | PACRGL | ENSG00000163138.14 | 7.446E-7 | 0 | 28867 | gtex_brain_putamen_basal |
| rs59189281 | 4 | 20729275 | PACRGL | ENSG00000163138.14 | 1.19E-6 | 0 | 31370 | gtex_brain_putamen_basal |
| rs143889232 | 4 | 20729988 | PACRGL | ENSG00000163138.14 | 1.787E-6 | 0 | 32083 | gtex_brain_putamen_basal |
| rs2114474 | 4 | 20733270 | PACRGL | ENSG00000163138.14 | 5.41E-7 | 0 | 35365 | gtex_brain_putamen_basal |
| rs398092219 | 4 | 20733708 | PACRGL | ENSG00000163138.14 | 6.775E-8 | 0 | 35803 | gtex_brain_putamen_basal |
| rs6811933 | 4 | 20734176 | PACRGL | ENSG00000163138.14 | 6.296E-7 | 0 | 36271 | gtex_brain_putamen_basal |
| rs11436210 | 4 | 20738921 | PACRGL | ENSG00000163138.14 | 1.098E-6 | 0 | 41016 | gtex_brain_putamen_basal |
| rs6858843 | 4 | 20739530 | PACRGL | ENSG00000163138.14 | 8.275E-7 | 0 | 41625 | gtex_brain_putamen_basal |
| rs61428210 | 4 | 20739905 | PACRGL | ENSG00000163138.14 | 2.378E-6 | 0 | 42000 | gtex_brain_putamen_basal |
| rs7660187 | 4 | 20740426 | PACRGL | ENSG00000163138.14 | 9.272E-7 | 0 | 42521 | gtex_brain_putamen_basal |
| rs2322687 | 4 | 20741823 | PACRGL | ENSG00000163138.14 | 8.826E-7 | 0 | 43918 | gtex_brain_putamen_basal |
| rs201477394 | 4 | 20750180 | PACRGL | ENSG00000163138.14 | 2.482E-6 | 0 | 52275 | gtex_brain_putamen_basal |
| rs7663837 | 4 | 20752852 | PACRGL | ENSG00000163138.14 | 1.915E-6 | 0 | 54947 | gtex_brain_putamen_basal |
| rs7689421 | 4 | 20755240 | PACRGL | ENSG00000163138.14 | 1.862E-6 | 0 | 57335 | gtex_brain_putamen_basal |
| rs3816874 | 4 | 20756490 | PACRGL | ENSG00000163138.14 | 1.303E-6 | 0 | 58585 | gtex_brain_putamen_basal |
| rs11723855 | 4 | 20758861 | PACRGL | ENSG00000163138.14 | 2.487E-7 | 0 | 60956 | gtex_brain_putamen_basal |
| rs7694208 | 4 | 20759614 | PACRGL | ENSG00000163138.14 | 1.818E-6 | 0 | 61709 | gtex_brain_putamen_basal |
| rs5856577 | 4 | 20761266 | PACRGL | ENSG00000163138.14 | 9.572E-7 | 0 | 63361 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| GOLDRATH HOMEOSTATIC PROLIFERATION | 171 | 102 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| RAMALHO STEMNESS UP | 206 | 118 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |