Gene Page: ADORA2A

Summary ?
GeneID135
SymbolADORA2A
SynonymsA2aR|ADORA2|RDC8
Descriptionadenosine A2a receptor
ReferenceMIM:102776|HGNC:HGNC:263|Ensembl:ENSG00000128271|Ensembl:ENSG00000258555|HPRD:00043|Vega:OTTHUMG00000150761
Gene typeprotein-coding
Map location22q11.23
Pascal p-value0.434
Sherlock p-value0.973
Fetal beta0.578
eGeneMyers' cis & trans
SupportGPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1128 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs596985chr164277034ADORA2A1350.15trans
rs16838771chr1157511227ADORA2A1352.199E-5trans
rs17575539chr262766126ADORA2A1350.13trans
rs17019687chr280972176ADORA2A1350.14trans
rs1881496chr2233372354ADORA2A1350.04trans
rs6803351chr317336986ADORA2A1350.04trans
rs11916205chr317392363ADORA2A1350.04trans
rs17043486chr317399005ADORA2A1350.04trans
rs17029249chr317416384ADORA2A1350.04trans
rs17043623chr317478890ADORA2A1350.04trans
rs11128830chr317481727ADORA2A1350.04trans
rs17044097chr317889750ADORA2A1350.04trans
rs17044102chr317889838ADORA2A1350.12trans
rs46277720ADORA2A1350.06trans
rs17079580chr347363841ADORA2A1350.06trans
rs12633404chr380381837ADORA2A1350.01trans
rs12637719chr385328350ADORA2A1352.888E-4trans
rs17647031chr3116102744ADORA2A1350.18trans
rs16864324chr3189106780ADORA2A1350.2trans
rs12651357chr453029658ADORA2A1350.18trans
rs9996479chr453029771ADORA2A1350.18trans
rs3025740chr4114163593ADORA2A1350.02trans
snp_a-41952940ADORA2A1350.03trans
rs16894524chr565192799ADORA2A1350.15trans
rs17459137chr5114603454ADORA2A1350.06trans
rs3812061chr5126213763ADORA2A1350.01trans
rs12655258chr5126267350ADORA2A1350.05trans
rs12652390chr5126322101ADORA2A1352.15E-4trans
rs17165249chr5126395510ADORA2A1350.12trans
rs17165234chr5126403634ADORA2A1353.703E-7trans
rs12655006chr5126407601ADORA2A1350.04trans
rs12656879chr5126599075ADORA2A1350.1trans
rs3733727chr5134689299ADORA2A1350.06trans
rs2270172chr630592413ADORA2A1350.02trans
rs1041915chr6130014252ADORA2A1350.16trans
rs9397728chr6150514248ADORA2A1352.437E-4trans
rs11987753chr8110166238ADORA2A1350.04trans
rs10963890chr918977332ADORA2A1350.07trans
rs6479279chr9107476888ADORA2A1350.16trans
rs2066315chr10514137ADORA2A1350.03trans
rs10794751chr101514218ADORA2A1350.2trans
rs1440195chr11116183393ADORA2A1350.08trans
rs11178166chr1270670585ADORA2A1350.05trans
rs2297479chr12125591249ADORA2A1350.08trans
rs9603093chr1337337849ADORA2A1350.04trans
rs854406chr1425204350ADORA2A1350.11trans
rs8008199chr1431002111ADORA2A1350.1trans
rs4981760chr1431002684ADORA2A1350.02trans
rs230349chr1431130389ADORA2A1350.09trans
rs230365chr1431139870ADORA2A1350.16trans
rs11628947chr1431161925ADORA2A1350.16trans
rs17104965chr1437145915ADORA2A1350trans
rs17105036chr1437154593ADORA2A1350trans
rs362341chr1473641457ADORA2A1350.04trans
rs4564513chr1557960009ADORA2A1350.11trans
rs8056861chr1656921039ADORA2A1350trans
rs443222chr1683889679ADORA2A1350.01trans
rs824575chr1683891459ADORA2A1350.01trans
rs1056626chr174931552ADORA2A1350.19trans
rs355306chr1833105716ADORA2A1350.01trans
rs7504799chr1870057077ADORA2A1350.19trans
rs10405894chr1952631599ADORA2A1350.12trans
rs6102879chr2041138766ADORA2A1350.18trans
rs2835891chr2139056226ADORA2A1350.01trans
rs1883665chrX17650382ADORA2A1354.912E-6trans
rs7062071chrX17724830ADORA2A1350.01trans
rs12690023chrX50830077ADORA2A1350.15trans
rs7879274chrX145592957ADORA2A1350.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001609adenosine receptor activity, G-protein coupledIEA-
GO:0004872receptor activityIEA-
GO:0016519gastric inhibitory peptide receptor activityNAS8522976 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)10945659 
GO:0032230positive regulation of synaptic transmission, GABAergicIEAneuron, GABA, Synap, Neurotransmitter (GO term level: 10)-
GO:0001963synaptic transmission, dopaminergicIEAneuron, Synap, Neurotransmitter, dopamine (GO term level: 8)-
GO:0006836neurotransmitter transportNASneuron, Neurotransmitter (GO term level: 5)8522976 
GO:0001975response to amphetamineIEA-
GO:0001973adenosine receptor signaling pathwayIEA-
GO:0007190activation of adenylate cyclase activityEXP16805430 
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS10899090 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007267cell-cell signalingTAS7818494 
GO:0006171cAMP biosynthetic processTAS10899090 
GO:0006968cellular defense responseTAS10051547 
GO:0007165signal transductionIEA-
GO:0008015blood circulationTAS9262401 
GO:0007626locomotory behaviorIEA-
GO:0007600sensory perceptionTAS9262401 
GO:0007596blood coagulationTAS10899090 
GO:0006954inflammatory responseTAS8360491 
GO:0006915apoptosisTAS7818494 
GO:0006909phagocytosisTAS8360491 
GO:0042755eating behaviorIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005624membrane fractionTAS10051547 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS8794889 |10051547 
GO:0005887integral to plasma membraneTAS8794889 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY 3429All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS 168All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 4834All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 8WK 4738All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 7962All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 5132All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 8754All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 15692All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION B 5336All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
CERIBELLI GENES INACTIVE AND BOUND BY NFY 4527All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-214537543m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-34b786792m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG