Gene Page: CR1L
Summary ?
GeneID | 1379 |
Symbol | CR1L |
Synonyms | - |
Description | complement component 3b/4b receptor 1-like |
Reference | MIM:605886|HGNC:HGNC:2335|Ensembl:ENSG00000197721|Vega:OTTHUMG00000036354 |
Gene type | protein-coding |
Map location | 1q32.1 |
Support | CompositeSet |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
---|---|---|---|---|---|---|---|---|---|---|---|
CR1L | chr1 | 207891009 | C | G | NM_175710 | p.539P>A | missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ZNF384 | 0.96 | 0.96 |
GTF3C2 | 0.95 | 0.95 |
SMPD4 | 0.95 | 0.96 |
MOGS | 0.95 | 0.96 |
NXF1 | 0.94 | 0.93 |
PPIL2 | 0.94 | 0.95 |
PCIF1 | 0.94 | 0.95 |
SF1 | 0.94 | 0.93 |
YY1AP1 | 0.94 | 0.94 |
CNOT3 | 0.94 | 0.94 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.79 | -0.89 |
AF347015.27 | -0.77 | -0.88 |
MT-CO2 | -0.77 | -0.88 |
C5orf53 | -0.75 | -0.78 |
MT-CYB | -0.74 | -0.86 |
AF347015.33 | -0.74 | -0.84 |
AF347015.8 | -0.74 | -0.87 |
AF347015.21 | -0.71 | -0.91 |
S100B | -0.71 | -0.78 |
AF347015.15 | -0.70 | -0.83 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
IWANAGA CARCINOGENESIS BY KRAS PTEN UP | 181 | 112 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER CANCER WITH H3K27ME3 UP | 295 | 149 | All SZGR 2.0 genes in this pathway |
COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |