Gene Page: CRK
Summary ?
GeneID | 1398 |
Symbol | CRK |
Synonyms | CRKII|p38 |
Description | v-crk avian sarcoma virus CT10 oncogene homolog |
Reference | MIM:164762|HGNC:HGNC:2362|Ensembl:ENSG00000167193|HPRD:01267|Vega:OTTHUMG00000090317 |
Gene type | protein-coding |
Map location | 17p13.3 |
Pascal p-value | 1.329E-5 |
Sherlock p-value | 1.549E-5 |
Fetal beta | 1.082 |
eGene | Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.4103 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
SLC39A6 | 0.95 | 0.95 |
EIF4G2 | 0.94 | 0.95 |
XRCC5 | 0.94 | 0.95 |
WDR40A | 0.94 | 0.93 |
GPN1 | 0.94 | 0.93 |
HSDL1 | 0.93 | 0.95 |
GART | 0.93 | 0.94 |
PTBP2 | 0.93 | 0.95 |
YWHAQ | 0.93 | 0.92 |
C10orf119 | 0.92 | 0.92 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.27 | -0.74 | -0.88 |
AF347015.31 | -0.74 | -0.89 |
MT-CO2 | -0.74 | -0.91 |
AF347015.33 | -0.73 | -0.87 |
C5orf53 | -0.72 | -0.74 |
MT-CYB | -0.72 | -0.88 |
FXYD1 | -0.72 | -0.86 |
AF347015.8 | -0.71 | -0.90 |
HLA-F | -0.71 | -0.75 |
AIFM3 | -0.70 | -0.74 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005515 | protein binding | IEA | - | |
GO:0005515 | protein binding | IPI | 9788432 |9819391 |11278465 |14657239 |15886098 |16713569 | |
GO:0042169 | SH2 domain binding | IPI | 9472046 | |
GO:0045309 | protein phosphorylated amino acid binding | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 10748058 | |
GO:0007242 | intracellular signaling cascade | EXP | 9069267 | |
GO:0030036 | actin cytoskeleton organization | TAS | 10748058 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005829 | cytosol | EXP | 16284401 | |
GO:0005634 | nucleus | TAS | 10748058 | |
GO:0005737 | cytoplasm | TAS | 10748058 | |
GO:0005768 | endosome | EXP | 7806500 | |
GO:0005886 | plasma membrane | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | c-Abl interacts with Crk. This interaction was modeled on a demonstrated interaction between human c-Abl and Crk from an unspecified species. | BIND | 15696159 |
ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | Interaction between ABL (PDB ID: 1JU5_C) and CRK (PDB ID: 1JU5_A). | BIND | 12384576 |
ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK. | BIND | 15886098 |
ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | - | HPRD | 8875975 |
ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | ABL2 (Arg) phosphorylates CRK. | BIND | 15735735 |
ARHGAP17 | DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15 | Rho GTPase activating protein 17 | Reconstituted Complex | BioGRID | 11431473 |
ASAP1 | AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14P | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | Reconstituted Complex | BioGRID | 9819391 |
ASAP1 | AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14P | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | DDEF1 (AMAP1) interacts with an unspecified isoform of CRK (Crk II). | BIND | 15719014 |
AVIL | ADVIL | DKFZp779O1812 | DOC6 | FLJ12386 | MGC133244 | p92 | advillin | - | HPRD,BioGRID | 11287316 |
BCAR1 | CAS | CAS1 | CASS1 | CRKAS | P130Cas | breast cancer anti-estrogen resistance 1 | Affinity Capture-Western Reconstituted Complex | BioGRID | 9581808 |9920935 |10085298 |10329689 |11369773 |12615911 |14657239 |15492270 |
BUB1 | BUB1A | BUB1L | hBUB1 | budding uninhibited by benzimidazoles 1 homolog (yeast) | Two-hybrid | BioGRID | 16189514 |
CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Affinity Capture-Western | BioGRID | 9178909 |9461587 |
CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | - | HPRD | 8621483 |8662998 |
CBLC | CBL-3 | CBL-SL | RNF57 | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | - | HPRD,BioGRID | 10362357 |
CBLC | CBL-3 | CBL-SL | RNF57 | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | - | HPRD | 10362357 |10571044 |
CRKL | - | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | - | HPRD | 9614078 |
DAB1 | - | disabled homolog 1 (Drosophila) | - | HPRD | 15062102 |
DOCK1 | DOCK180 | ced5 | dedicator of cytokinesis 1 | Affinity Capture-Western Co-fractionation Reconstituted Complex | BioGRID | 8657152 |8662907 |10559471 |11369773 |12615911 |
DOCK1 | DOCK180 | ced5 | dedicator of cytokinesis 1 | - | HPRD | 8657152|11369773 |
DOCK3 | KIAA0299 | MOCA | PBP | dedicator of cytokinesis 3 | - | HPRD | 10854253 |
DOK4 | FLJ10488 | docking protein 4 | - | HPRD | 12730241 |
DOK4 | FLJ10488 | docking protein 4 | IRS5/DOK4 interacts with Crk. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Crk. | BIND | 12730241 |
DPPA4 | 2410091M23Rik | FLJ10713 | developmental pluripotency associated 4 | Two-hybrid | BioGRID | 16189514 |
EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD,BioGRID | 9642287 |
EPHA3 | ETK | ETK1 | HEK | HEK4 | TYRO4 | EPH receptor A3 | - | HPRD,BioGRID | 11870224 |
EPHB2 | CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5 | EPH receptor B2 | Reconstituted Complex | BioGRID | 10644995 |
EPHB3 | ETK2 | HEK2 | TYRO6 | EPH receptor B3 | - | HPRD,BioGRID | 9674711 |
EPS15 | AF-1P | AF1P | MLLT5 | epidermal growth factor receptor pathway substrate 15 | - | HPRD,BioGRID | 7797522 |
ERBB4 | HER4 | MGC138404 | p180erbB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | Affinity Capture-MS | BioGRID | 16729043 |
FRS2 | FRS2A | FRS2alpha | SNT | SNT-1 | SNT1 | fibroblast growth factor receptor substrate 2 | Reconstituted Complex | BioGRID | 10092678 |
GAB1 | - | GRB2-associated binding protein 1 | - | HPRD | 12138161 |
GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | Affinity Capture-Western Far Western Reconstituted Complex | BioGRID | 8662907 |8810325 |10970810 |
GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD | 8662907 |10970810 |
IRS4 | IRS-4 | PY160 | insulin receptor substrate 4 | - | HPRD,BioGRID | 9614078 |11316748 |
KCNIP3 | CSEN | DREAM | KCHIP3 | MGC18289 | Kv channel interacting protein 3, calsenilin | Affinity Capture-Western | BioGRID | 10854253 |
KHDRBS1 | FLJ34027 | Sam68 | p62 | KH domain containing, RNA binding, signal transduction associated 1 | Reconstituted Complex | BioGRID | 1545818 |
MAP4K1 | HPK1 | mitogen-activated protein kinase kinase kinase kinase 1 | HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates Crk, an adaptor protein. | BIND | 9891069 |
MAP4K1 | HPK1 | mitogen-activated protein kinase kinase kinase kinase 1 | - | HPRD | 9891069 |11432831 |
MAP4K1 | HPK1 | mitogen-activated protein kinase kinase kinase kinase 1 | Affinity Capture-Western Reconstituted Complex | BioGRID | 9788432 |9891069 |
MAP4K5 | GCKR | KHS | KHS1 | MAPKKKK5 | mitogen-activated protein kinase kinase kinase kinase 5 | - | HPRD,BioGRID | 10648385 |
MAPK8 | JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 | mitogen-activated protein kinase 8 | - | HPRD,BioGRID | 11432831 |
MICAL1 | DKFZp434B1517 | FLJ11937 | FLJ21739 | MICAL | MICAL-1 | NICAL | microtubule associated monoxygenase, calponin and LIM domain containing 1 | Reconstituted Complex | BioGRID | 11827972 |
NCK1 | MGC12668 | NCK | NCKalpha | NCK adaptor protein 1 | Reconstituted Complex | BioGRID | 8879209 |
NEDD9 | CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1 | neural precursor cell expressed, developmentally down-regulated 9 | - | HPRD | 8879209 |9366405 |9497377 |
NEDD9 | CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1 | neural precursor cell expressed, developmentally down-regulated 9 | Affinity Capture-Western Reconstituted Complex | BioGRID | 8879209 |9497377 |
PDGFRA | CD140A | MGC74795 | PDGFR2 | Rhe-PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | - | HPRD,BioGRID | 9546424 |10733900 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | PDGFR interacts with Crk. This interaction was modelled on a demonstrated interaction between rat PDGFR and Crk from an unknown species. | BIND | 2173144 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | - | HPRD,BioGRID | 10733900 |
PLSCR1 | MMTRA1B | phospholipid scramblase 1 | Two-hybrid | BioGRID | 16189514 |
PSMC6 | CADP44 | MGC12520 | P44 | SUG2 | p42 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | Two-hybrid | BioGRID | 16189514 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | Affinity Capture-Western Reconstituted Complex | BioGRID | 10085298 |12615911 |
PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD | 10329689 |
PTPN1 | PTP1B | protein tyrosine phosphatase, non-receptor type 1 | Reconstituted Complex | BioGRID | 8940134 |
PXN | FLJ16691 | paxillin | - | HPRD,BioGRID | 12198159 |
RAPGEF1 | C3G | DKFZp781P1719 | GRF2 | Rap guanine nucleotide exchange factor (GEF) 1 | - | HPRD | 7512734|11870224 |12054111 |
RAPGEF1 | C3G | DKFZp781P1719 | GRF2 | Rap guanine nucleotide exchange factor (GEF) 1 | - | HPRD,BioGRID | 7512734 |8621483 |11870224 |12054111 |
RET | CDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51 | ret proto-oncogene | Reconstituted Complex | BioGRID | 9393871 |
RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase-activating protein | Crk interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Crk from an unspecified species and human GC-GAP. | BIND | 12819203 |
RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase-activating protein | Affinity Capture-Western Reconstituted Complex | BioGRID | 12454018 |12819203 |
RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase-activating protein | - | HPRD | 12446789 |12454018 |
SH3BP1 | - | SH3-domain binding protein 1 | - | HPRD,BioGRID | 1379745 |
SH3KBP1 | CIN85 | GIG10 | MIG18 | SH3-domain kinase binding protein 1 | Affinity Capture-Western | BioGRID | 11071869 |
SHB | RP11-3J10.8 | bA3J10.2 | Src homology 2 domain containing adaptor protein B | - | HPRD,BioGRID | 10964504 |
SNIP | KIAA1684 | SNAP25-interacting protein | - | HPRD,BioGRID | 14657239 |
SOCS1 | CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3 | suppressor of cytokine signaling 1 | Reconstituted Complex | BioGRID | 10022833 |
SOS1 | GF1 | GGF1 | GINGF | HGF | NS4 | son of sevenless homolog 1 (Drosophila) | - | HPRD,BioGRID | 8810325 |
SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Affinity Capture-Western | BioGRID | 12615911 |
SYN1 | SYN1a | SYN1b | SYNI | synapsin I | - | HPRD,BioGRID | 10899172 |
VAV1 | VAV | vav 1 guanine nucleotide exchange factor | - | HPRD | 8621483 |
VAV2 | - | vav 2 guanine nucleotide exchange factor | Crk interacts with Vav. | BIND | 8621483 |
WEE1 | DKFZp686I18166 | FLJ16446 | WEE1A | WEE1hu | WEE1 homolog (S. pombe) | - | HPRD,BioGRID | 11839808 |
XPO1 | CRM1 | DKFZp686B1823 | exportin 1 (CRM1 homolog, yeast) | - | HPRD,BioGRID | 11839808 |
ZAP70 | FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 | zeta-chain (TCR) associated protein kinase 70kDa | - | HPRD,BioGRID | 10419455 |
ZAP70 | FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 | zeta-chain (TCR) associated protein kinase 70kDa | ZAP-70 interacts with Crk-I. | BIND | 10419455 |
ZAP70 | FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 | zeta-chain (TCR) associated protein kinase 70kDa | ZAP-70 interacts with Crk-II. | BIND | 10419455 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
KEGG ERBB SIGNALING PATHWAY | 87 | 71 | All SZGR 2.0 genes in this pathway |
KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
KEGG FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS | 97 | 71 | All SZGR 2.0 genes in this pathway |
KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | All SZGR 2.0 genes in this pathway |
KEGG INSULIN SIGNALING PATHWAY | 137 | 103 | All SZGR 2.0 genes in this pathway |
KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
KEGG RENAL CELL CARCINOMA | 70 | 60 | All SZGR 2.0 genes in this pathway |
KEGG CHRONIC MYELOID LEUKEMIA | 73 | 59 | All SZGR 2.0 genes in this pathway |
BIOCARTA CXCR4 PATHWAY | 24 | 22 | All SZGR 2.0 genes in this pathway |
BIOCARTA MET PATHWAY | 37 | 30 | All SZGR 2.0 genes in this pathway |
ST INTEGRIN SIGNALING PATHWAY | 82 | 62 | All SZGR 2.0 genes in this pathway |
PID ENDOTHELIN PATHWAY | 63 | 52 | All SZGR 2.0 genes in this pathway |
PID LYSOPHOSPHOLIPID PATHWAY | 66 | 53 | All SZGR 2.0 genes in this pathway |
PID INSULIN PATHWAY | 45 | 32 | All SZGR 2.0 genes in this pathway |
PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
PID PTP1B PATHWAY | 52 | 40 | All SZGR 2.0 genes in this pathway |
PID EPHB FWD PATHWAY | 40 | 38 | All SZGR 2.0 genes in this pathway |
PID NECTIN PATHWAY | 30 | 20 | All SZGR 2.0 genes in this pathway |
PID RET PATHWAY | 39 | 29 | All SZGR 2.0 genes in this pathway |
PID ANGIOPOIETIN RECEPTOR PATHWAY | 50 | 41 | All SZGR 2.0 genes in this pathway |
PID CXCR4 PATHWAY | 102 | 78 | All SZGR 2.0 genes in this pathway |
PID IGF1 PATHWAY | 30 | 23 | All SZGR 2.0 genes in this pathway |
PID ECADHERIN NASCENT AJ PATHWAY | 39 | 33 | All SZGR 2.0 genes in this pathway |
PID UPA UPAR PATHWAY | 42 | 30 | All SZGR 2.0 genes in this pathway |
PID EPHA FWDPATHWAY | 34 | 29 | All SZGR 2.0 genes in this pathway |
PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
PID TRKR PATHWAY | 62 | 48 | All SZGR 2.0 genes in this pathway |
PID TCR JNK PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
PID PDGFRA PATHWAY | 22 | 18 | All SZGR 2.0 genes in this pathway |
PID LYMPH ANGIOGENESIS PATHWAY | 25 | 16 | All SZGR 2.0 genes in this pathway |
PID INTEGRIN A4B1 PATHWAY | 33 | 24 | All SZGR 2.0 genes in this pathway |
PID RAC1 PATHWAY | 54 | 37 | All SZGR 2.0 genes in this pathway |
PID FAK PATHWAY | 59 | 45 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 87 | 64 | All SZGR 2.0 genes in this pathway |
REACTOME ARMS MEDIATED ACTIVATION | 17 | 17 | All SZGR 2.0 genes in this pathway |
REACTOME PROLONGED ERK ACTIVATION EVENTS | 19 | 18 | All SZGR 2.0 genes in this pathway |
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALLING TO ERKS | 36 | 30 | All SZGR 2.0 genes in this pathway |
REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 79 | 48 | All SZGR 2.0 genes in this pathway |
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | 15 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 27 | 17 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY PDGF | 122 | 93 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 95 | 76 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF SIGNALING BY CBL | 18 | 16 | All SZGR 2.0 genes in this pathway |
REACTOME IL 3 5 AND GM CSF SIGNALING | 43 | 34 | All SZGR 2.0 genes in this pathway |
REACTOME PLATELET AGGREGATION PLUG FORMATION | 36 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY INSULIN RECEPTOR | 108 | 72 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNAL ATTENUATION | 14 | 8 | All SZGR 2.0 genes in this pathway |
REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 208 | 138 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
WANG CLIM2 TARGETS DN | 186 | 114 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
MCBRYAN PUBERTAL BREAST 3 4WK UP | 214 | 144 | All SZGR 2.0 genes in this pathway |
MCBRYAN PUBERTAL BREAST 5 6WK DN | 137 | 97 | All SZGR 2.0 genes in this pathway |
MCBRYAN PUBERTAL BREAST 6 7WK UP | 197 | 135 | All SZGR 2.0 genes in this pathway |
MCBRYAN PUBERTAL TGFB1 TARGETS UP | 169 | 127 | All SZGR 2.0 genes in this pathway |
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | All SZGR 2.0 genes in this pathway |
RASHI RESPONSE TO IONIZING RADIATION 5 | 147 | 89 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
GEORGES CELL CYCLE MIR192 TARGETS | 62 | 46 | All SZGR 2.0 genes in this pathway |
GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
STONER ESOPHAGEAL CARCINOGENESIS UP | 39 | 25 | All SZGR 2.0 genes in this pathway |
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | All SZGR 2.0 genes in this pathway |
HELLER HDAC TARGETS UP | 317 | 208 | All SZGR 2.0 genes in this pathway |
LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
PHONG TNF RESPONSE VIA P38 COMPLETE | 227 | 151 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-1/206 | 664 | 670 | 1A | hsa-miR-1 | UGGAAUGUAAAGAAGUAUGUA |
hsa-miR-206SZ | UGGAAUGUAAGGAAGUGUGUGG | ||||
hsa-miR-613 | AGGAAUGUUCCUUCUUUGCC | ||||
miR-10 | 175 | 181 | 1A | hsa-miR-10a | UACCCUGUAGAUCCGAAUUUGUG |
hsa-miR-10b | UACCCUGUAGAACCGAAUUUGU | ||||
miR-126/126-3p | 178 | 184 | 1A | hsa-miR-126brain | UCGUACCGUGAGUAAUAAUGC |
miR-133 | 913 | 919 | 1A | hsa-miR-133a | UUGGUCCCCUUCAACCAGCUGU |
hsa-miR-133b | UUGGUCCCCUUCAACCAGCUA | ||||
miR-142-3p | 536 | 542 | m8 | hsa-miR-142-3p | UGUAGUGUUUCCUACUUUAUGGA |
miR-142-5p | 695 | 701 | m8 | hsa-miR-142-5p | CAUAAAGUAGAAAGCACUAC |
miR-151 | 94 | 100 | m8 | hsa-miR-151brain | ACUAGACUGAAGCUCCUUGAGG |
miR-17-5p/20/93.mr/106/519.d | 693 | 700 | 1A,m8 | hsa-miR-17-5p | CAAAGUGCUUACAGUGCAGGUAGU |
hsa-miR-20abrain | UAAAGUGCUUAUAGUGCAGGUAG | ||||
hsa-miR-106a | AAAAGUGCUUACAGUGCAGGUAGC | ||||
hsa-miR-106bSZ | UAAAGUGCUGACAGUGCAGAU | ||||
hsa-miR-20bSZ | CAAAGUGCUCAUAGUGCAGGUAG | ||||
hsa-miR-519d | CAAAGUGCCUCCCUUUAGAGUGU | ||||
miR-186 | 591 | 597 | m8 | hsa-miR-186 | CAAAGAAUUCUCCUUUUGGGCUU |
miR-320 | 711 | 717 | 1A | hsa-miR-320 | AAAAGCUGGGUUGAGAGGGCGAA |
miR-325 | 539 | 546 | 1A,m8 | hsa-miR-325 | CCUAGUAGGUGUCCAGUAAGUGU |
miR-377 | 443 | 449 | 1A | hsa-miR-377 | AUCACACAAAGGCAACUUUUGU |
miR-381 | 981 | 988 | 1A,m8 | hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU |
miR-410 | 102 | 108 | 1A | hsa-miR-410 | AAUAUAACACAGAUGGCCUGU |
miR-93.hd/291-3p/294/295/302/372/373/520 | 692 | 698 | m8 | hsa-miR-93brain | AAAGUGCUGUUCGUGCAGGUAG |
hsa-miR-302a | UAAGUGCUUCCAUGUUUUGGUGA | ||||
hsa-miR-302b | UAAGUGCUUCCAUGUUUUAGUAG | ||||
hsa-miR-302c | UAAGUGCUUCCAUGUUUCAGUGG | ||||
hsa-miR-302d | UAAGUGCUUCCAUGUUUGAGUGU | ||||
hsa-miR-372 | AAAGUGCUGCGACAUUUGAGCGU | ||||
hsa-miR-373 | GAAGUGCUUCGAUUUUGGGGUGU | ||||
hsa-miR-520e | AAAGUGCUUCCUUUUUGAGGG | ||||
hsa-miR-520a | AAAGUGCUUCCCUUUGGACUGU | ||||
hsa-miR-520b | AAAGUGCUUCCUUUUAGAGGG | ||||
hsa-miR-520c | AAAGUGCUUCCUUUUAGAGGGUU | ||||
hsa-miR-520d | AAAGUGCUUCUCUUUGGUGGGUU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.