SZGR2

Summary ?

GeneID	1398
Symbol	CRK
Synonyms	CRKII\|p38
Description	v-crk avian sarcoma virus CT10 oncogene homolog
Reference	MIM:164762\|HGNC:HGNC:2362\|Ensembl:ENSG00000167193\|HPRD:01267\|Vega:OTTHUMG00000090317
Gene type	protein-coding
Map location	17p13.3
Pascal p-value	1.329E-5
Sherlock p-value	1.549E-5
Fetal beta	1.082
eGene	Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.4103

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC39A6	0.95	0.95
EIF4G2	0.94	0.95
XRCC5	0.94	0.95
WDR40A	0.94	0.93
GPN1	0.94	0.93
HSDL1	0.93	0.95
GART	0.93	0.94
PTBP2	0.93	0.95
YWHAQ	0.93	0.92
C10orf119	0.92	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.27	-0.74	-0.88
AF347015.31	-0.74	-0.89
MT-CO2	-0.74	-0.91
AF347015.33	-0.73	-0.87
C5orf53	-0.72	-0.74
MT-CYB	-0.72	-0.88
FXYD1	-0.72	-0.86
AF347015.8	-0.71	-0.90
HLA-F	-0.71	-0.75
AIFM3	-0.70	-0.74

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		9788432 \|9819391 \|11278465 \|14657239 \|15886098 \|16713569
GO:0042169	SH2 domain binding	IPI		9472046
GO:0045309	protein phosphorylated amino acid binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS		10748058
GO:0007242	intracellular signaling cascade	EXP		9069267
GO:0030036	actin cytoskeleton organization	TAS		10748058
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		16284401
GO:0005634	nucleus	TAS		10748058
GO:0005737	cytoplasm	TAS		10748058
GO:0005768	endosome	EXP		7806500
GO:0005886	plasma membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	c-Abl interacts with Crk. This interaction was modeled on a demonstrated interaction between human c-Abl and Crk from an unspecified species.	BIND	15696159
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Interaction between ABL (PDB ID: 1JU5_C) and CRK (PDB ID: 1JU5_A).	BIND	12384576
ABL2	ABLL \| ARG \| FLJ22224 \| FLJ31718 \| FLJ41441	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK.	BIND	15886098
ABL2	ABLL \| ARG \| FLJ22224 \| FLJ31718 \| FLJ41441	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	-	HPRD	8875975
ABL2	ABLL \| ARG \| FLJ22224 \| FLJ31718 \| FLJ41441	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	ABL2 (Arg) phosphorylates CRK.	BIND	15735735
ARHGAP17	DKFZp564A1363 \| FLJ37567 \| FLJ43368 \| MGC87805 \| MST066 \| MST110 \| MSTP038 \| MSTP066 \| MSTP110 \| NADRIN \| RICH1 \| WBP15	Rho GTPase activating protein 17	Reconstituted Complex	BioGRID	11431473
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Reconstituted Complex	BioGRID	9819391
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	DDEF1 (AMAP1) interacts with an unspecified isoform of CRK (Crk II).	BIND	15719014
AVIL	ADVIL \| DKFZp779O1812 \| DOC6 \| FLJ12386 \| MGC133244 \| p92	advillin	-	HPRD,BioGRID	11287316
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9581808 \|9920935 \|10085298 \|10329689 \|11369773 \|12615911 \|14657239 \|15492270
BUB1	BUB1A \| BUB1L \| hBUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	Two-hybrid	BioGRID	16189514
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Affinity Capture-Western	BioGRID	9178909 \|9461587
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD	8621483 \|8662998
CBLC	CBL-3 \| CBL-SL \| RNF57	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	-	HPRD,BioGRID	10362357
CBLC	CBL-3 \| CBL-SL \| RNF57	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	-	HPRD	10362357 \|10571044
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	-	HPRD	9614078
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD	15062102
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Affinity Capture-Western Co-fractionation Reconstituted Complex	BioGRID	8657152 \|8662907 \|10559471 \|11369773 \|12615911
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	-	HPRD	8657152\|11369773
DOCK3	KIAA0299 \| MOCA \| PBP	dedicator of cytokinesis 3	-	HPRD	10854253
DOK4	FLJ10488	docking protein 4	-	HPRD	12730241
DOK4	FLJ10488	docking protein 4	IRS5/DOK4 interacts with Crk. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Crk.	BIND	12730241
DPPA4	2410091M23Rik \| FLJ10713	developmental pluripotency associated 4	Two-hybrid	BioGRID	16189514
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9642287
EPHA3	ETK \| ETK1 \| HEK \| HEK4 \| TYRO4	EPH receptor A3	-	HPRD,BioGRID	11870224
EPHB2	CAPB \| DRT \| EPHT3 \| ERK \| Hek5 \| MGC87492 \| PCBC \| Tyro5	EPH receptor B2	Reconstituted Complex	BioGRID	10644995
EPHB3	ETK2 \| HEK2 \| TYRO6	EPH receptor B3	-	HPRD,BioGRID	9674711
EPS15	AF-1P \| AF1P \| MLLT5	epidermal growth factor receptor pathway substrate 15	-	HPRD,BioGRID	7797522
ERBB4	HER4 \| MGC138404 \| p180erbB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	Affinity Capture-MS	BioGRID	16729043
FRS2	FRS2A \| FRS2alpha \| SNT \| SNT-1 \| SNT1	fibroblast growth factor receptor substrate 2	Reconstituted Complex	BioGRID	10092678
GAB1	-	GRB2-associated binding protein 1	-	HPRD	12138161
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8662907 \|8810325 \|10970810
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	8662907 \|10970810
IRS4	IRS-4 \| PY160	insulin receptor substrate 4	-	HPRD,BioGRID	9614078 \|11316748
KCNIP3	CSEN \| DREAM \| KCHIP3 \| MGC18289	Kv channel interacting protein 3, calsenilin	Affinity Capture-Western	BioGRID	10854253
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	Reconstituted Complex	BioGRID	1545818
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates Crk, an adaptor protein.	BIND	9891069
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	-	HPRD	9891069 \|11432831
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9788432 \|9891069
MAP4K5	GCKR \| KHS \| KHS1 \| MAPKKKK5	mitogen-activated protein kinase kinase kinase kinase 5	-	HPRD,BioGRID	10648385
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	-	HPRD,BioGRID	11432831
MICAL1	DKFZp434B1517 \| FLJ11937 \| FLJ21739 \| MICAL \| MICAL-1 \| NICAL	microtubule associated monoxygenase, calponin and LIM domain containing 1	Reconstituted Complex	BioGRID	11827972
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	Reconstituted Complex	BioGRID	8879209
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD	8879209 \|9366405 \|9497377
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	Affinity Capture-Western Reconstituted Complex	BioGRID	8879209 \|9497377
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	-	HPRD,BioGRID	9546424 \|10733900
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	PDGFR interacts with Crk. This interaction was modelled on a demonstrated interaction between rat PDGFR and Crk from an unknown species.	BIND	2173144
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	10733900
PLSCR1	MMTRA1B	phospholipid scramblase 1	Two-hybrid	BioGRID	16189514
PSMC6	CADP44 \| MGC12520 \| P44 \| SUG2 \| p42	proteasome (prosome, macropain) 26S subunit, ATPase, 6	Two-hybrid	BioGRID	16189514
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western Reconstituted Complex	BioGRID	10085298 \|12615911
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD	10329689
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	Reconstituted Complex	BioGRID	8940134
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	12198159
RAPGEF1	C3G \| DKFZp781P1719 \| GRF2	Rap guanine nucleotide exchange factor (GEF) 1	-	HPRD	7512734\|11870224 \|12054111
RAPGEF1	C3G \| DKFZp781P1719 \| GRF2	Rap guanine nucleotide exchange factor (GEF) 1	-	HPRD,BioGRID	7512734 \|8621483 \|11870224 \|12054111
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	Reconstituted Complex	BioGRID	9393871
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Crk interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Crk from an unspecified species and human GC-GAP.	BIND	12819203
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Affinity Capture-Western Reconstituted Complex	BioGRID	12454018 \|12819203
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD	12446789 \|12454018
SH3BP1	-	SH3-domain binding protein 1	-	HPRD,BioGRID	1379745
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	Affinity Capture-Western	BioGRID	11071869
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD,BioGRID	10964504
SNIP	KIAA1684	SNAP25-interacting protein	-	HPRD,BioGRID	14657239
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Reconstituted Complex	BioGRID	10022833
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	8810325
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western	BioGRID	12615911
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD,BioGRID	10899172
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD	8621483
VAV2	-	vav 2 guanine nucleotide exchange factor	Crk interacts with Vav.	BIND	8621483
WEE1	DKFZp686I18166 \| FLJ16446 \| WEE1A \| WEE1hu	WEE1 homolog (S. pombe)	-	HPRD,BioGRID	11839808
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	-	HPRD,BioGRID	11839808
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	-	HPRD,BioGRID	10419455
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	ZAP-70 interacts with Crk-I.	BIND	10419455
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	ZAP-70 interacts with Crk-II.	BIND	10419455

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY	24	22	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY	30	20	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID PDGFRA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY	25	16	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION	17	17	All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS	19	18	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	79	48	All SZGR 2.0 genes in this pathway
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	11	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	27	17	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF SIGNALING BY CBL	18	16	All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING	43	34	All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION	36	23	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL ATTENUATION	14	8	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN	137	97	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP	169	127	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP	181	108	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5	147	89	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS	62	46	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
STONER ESOPHAGEAL CARCINOGENESIS UP	39	25	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP	317	208	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE	227	151	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	664	670	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-10	175	181	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	175	181	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-126/126-3p	178	184	1A	hsa-miR-126^brain	UCGUACCGUGAGUAAUAAUGC
miR-133	913	919	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	913	919	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-142-3p	536	542	m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-142-5p	695	701	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-151	94	100	m8	hsa-miR-151^brain	ACUAGACUGAAGCUCCUUGAGG
miR-17-5p/20/93.mr/106/519.d	693	700	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-186	591	597	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-320	711	717	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-325	539	546	1A,m8	hsa-miR-325	CCUAGUAGGUGUCCAGUAAGUGU
miR-377	443	449	1A	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	981	988	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	102	108	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-93.hd/291-3p/294/295/302/372/373/520	692	698	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CRK