Summary ?
GeneID140735
SymbolDYNLL2
SynonymsDNCL1B|Dlc2|RSPH22
Descriptiondynein light chain LC8-type 2
ReferenceMIM:608942|HGNC:HGNC:24596|HPRD:06489|
Gene typeprotein-coding
Map location17q22
Pascal p-value0.57
Sherlock p-value0.522
Fetal beta-0.936
SupportINTRACELLULAR TRAFFICKING
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2L11BAM | BIM | BIM-alpha6 | BIM-beta6 | BIM-beta7 | BOD | BimEL | BimLBCL2-like 11 (apoptosis facilitator)Reconstituted ComplexBioGRID14561217 
BMFFLJ00065Bcl2 modifying factor-HPRD,BioGRID11546872 |14561217 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)Affinity Capture-WesternBioGRID10844022 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10844022 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1DAP-1 interacts with DLC-2.BIND11122378 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1-HPRD,BioGRID10844022 
DNAL4PIG27dynein, axonemal, light chain 4Two-hybridBioGRID16189514 
DYNC1I1DNCI1 | DNCIC1dynein, cytoplasmic 1, intermediate chain 1Two-hybridBioGRID16189514 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2Co-crystal StructureBioGRID14561217 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
GPHNGEPH | GPH | GPHRYN | KIAA1385gephyrin-HPRD12097491 
GPRIN2GRIN2 | KIAA0514 | MGC15171G protein regulated inducer of neurite outgrowth 2Two-hybridBioGRID16189514 
HOMER3HOMER-3homer homolog 3 (Drosophila)Two-hybridBioGRID16189514 
MYO5AGS1 | MYH12 | MYO5 | MYR12myosin VA (heavy chain 12, myoxin)Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10844022 |11546872 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2Affinity Capture-WesternBioGRID10844022 
THAP10-THAP domain containing 10Two-hybridBioGRID16189514 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosisTwo-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG VASOPRESSIN REGULATED WATER REABSORPTION 4430All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 9161All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 1712All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 3021All SZGR 2.0 genes in this pathway
WANG RESPONSE TO ANDROGEN UP 2921All SZGR 2.0 genes in this pathway
WANG RESPONSE TO FORSKOLIN UP 2317All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5 2621All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 12877All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171102All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS 6538All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION 4029All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 4526All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway