Gene Page: CRYBB2

Summary ?
GeneID1415
SymbolCRYBB2
SynonymsCCA2|CRYB2|CRYB2A|CTRCT3|D22S665
Descriptioncrystallin beta B2
ReferenceMIM:123620|HGNC:HGNC:2398|Ensembl:ENSG00000244752|HPRD:00430|Vega:OTTHUMG00000150905
Gene typeprotein-coding
Map location22q11.23
Pascal p-value0.222
Fetal beta-0.214
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6004667chr2225874463CRYBB214155.776E-37cis
rs6004668chr2225874501CRYBB214151.157E-36cis
rs1930961chr2225875264CRYBB214154.025E-33cis
rs6004673chr2225885352CRYBB214153.915E-36cis
rs9612986chr2225931436CRYBB214150.03cis
rs17103715chr148214622CRYBB214150.13trans
rs12087028chr1214084383CRYBB214150.16trans
rs1005427chr239831229CRYBB214150.02trans
rs17030866chr266039792CRYBB214150trans
rs17006586chr271191207CRYBB214155.282E-4trans
rs17043357chr2115445394CRYBB214150.05trans
rs10180903chr2223115728CRYBB214150.15trans
rs11942948chr45254657CRYBB214150.07trans
rs10109794chr867045936CRYBB214150.08trans
rs1870392chr867098510CRYBB214150.08trans
rs17149833chr1011247962CRYBB214150.06trans
rs11027761chr1124217623CRYBB214150.11trans
rs17760954chr1524258346CRYBB214150.01trans
rs17761129chr1524262387CRYBB214150.1trans
rs6004667chr2225874463CRYBB214151.788E-34trans
rs6004668chr2225874501CRYBB214153.836E-34trans
rs1930961chr2225875264CRYBB214151.363E-30trans
rs6004673chr2225885352CRYBB214151.515E-33trans
rs96205400CRYBB214150trans
rs10521410chrX38116721CRYBB214150.06trans
rs5984472chrX89331417CRYBB214150.02trans
rs471777chrX96382529CRYBB214150.16trans
rs5966995chrX96387170CRYBB214150.16trans
rs10481828chrX115505090CRYBB214150.07trans
rs5952167chrX115529371CRYBB214150.01trans
rs12353619chrX118408162CRYBB214150.02trans
rs16999361chrX123792007CRYBB214150trans
rs453855chrX145778002CRYBB214150.07trans
rs66533760CRYBB214150.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005212structural constituent of eye lensIEA-
GO:0042803protein homodimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007601visual perceptionTAS9158139 
GO:0050896response to stimulusIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
LY AGING MIDDLE UP 1411All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
CERIBELLI GENES INACTIVE AND BOUND BY NFY 4527All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway