SZGR2

Summary ?

GeneID	1440
Symbol	CSF3
Synonyms	C17orf33\|CSF3OS\|GCSF
Description	colony stimulating factor 3
Reference	MIM:138970\|HGNC:HGNC:2438\|Ensembl:ENSG00000108342\|HPRD:00736\|Vega:OTTHUMG00000133247
Gene type	protein-coding
Map location	17q11.2-q12
Pascal p-value	0.031
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs10915489	chr1	4321466	CSF3	1440	2.282E-8	trans
rs1342707	chr1	147264296	CSF3	1440	0	trans
rs6426945	chr1	154776529	CSF3	1440	0.02	trans
rs7550076	chr1	154776711	CSF3	1440	0.08	trans
rs529346	chr1	160743808	CSF3	1440	0.01	trans
rs2284755	chr1	168403681	CSF3	1440	0.08	trans
rs12080632	chr1	169039280	CSF3	1440	0.05	trans
rs6658896	chr1	206926845	CSF3	1440	0.11	trans
rs17022385	chr1	207357521	CSF3	1440	0.09	trans
rs6665928	chr1	215821430	CSF3	1440	0.01	trans
rs2907143	chr1	243147434	CSF3	1440	1.16E-6	trans
rs4665576	chr2	23472338	CSF3	1440	8.5E-5	trans
rs1597005	chr2	116736707	CSF3	1440	2.275E-7	trans
rs7573503	chr2	119004157	CSF3	1440	0.02	trans
rs4078756	chr2	177004114	CSF3	1440	0.14	trans
rs885378	chr2	239962436	CSF3	1440	0.11	trans
rs4955151	chr3	32499581	CSF3	1440	0.1	trans
rs17303478	chr3	47897366	CSF3	1440	0.01	trans
rs6762371	chr3	51871404	CSF3	1440	0.17	trans
rs3772753	chr3	124145424	CSF3	1440	0.2	trans
rs4680298	chr3	156387114	CSF3	1440	0.15	trans
rs16846456	chr3	172757337	CSF3	1440	4.397E-7	trans
rs11943295	chr4	13403854	CSF3	1440	0.1	trans
rs11943330	chr4	13403997	CSF3	1440	0.04	trans
rs11933841	chr4	13463990	CSF3	1440	0.1	trans
rs7693312	chr4	13874551	CSF3	1440	0.1	trans
rs16898010	chr4	19036545	CSF3	1440	5.993E-4	trans
rs6848885	chr4	21582684	CSF3	1440	0.13	trans
rs7664889	chr4	77087703	CSF3	1440	0.12	trans
rs2053487	chr4	77097335	CSF3	1440	0.11	trans
rs13117802	chr4	77103928	CSF3	1440	0.06	trans
rs4859625	chr4	77104528	CSF3	1440	0.06	trans
rs336304	chr4	143019414	CSF3	1440	0.06	trans
rs336306	chr4	143019811	CSF3	1440	0.06	trans
rs17052594	chr4	167698562	CSF3	1440	0.02	trans
rs1588967	chr4	183191436	CSF3	1440	0.06	trans
rs4702765	chr5	10927603	CSF3	1440	0.12	trans
rs31304	chr5	52942082	CSF3	1440	0.04	trans
rs7726346	chr5	80229097	CSF3	1440	0.04	trans
rs888819	chr5	80257108	CSF3	1440	0.04	trans
rs10063177	chr5	145081194	CSF3	1440	0.13	trans
rs12110030	chr5	150448646	CSF3	1440	0.03	trans
rs6863508	chr5	159131795	CSF3	1440	0.01	trans
rs793014	chr5	172288950	CSF3	1440	0.06	trans
rs6886832	chr5	177874002	CSF3	1440	0.06	trans
rs2281127	chr6	11735767	CSF3	1440	0.01	trans
rs9466823	chr6	23572932	CSF3	1440	0.14	trans
rs7750692	chr6	69246088	CSF3	1440	0.13	trans
rs10952038	chr7	7176854	CSF3	1440	0.08	trans
rs6960358	chr7	19307526	CSF3	1440	0.01	trans
rs2191892	chr7	19327087	CSF3	1440	0.05	trans
rs2944816	chr7	71808838	CSF3	1440	0.03	trans
rs12536066	chr7	101263880	CSF3	1440	0.07	trans
rs2527853	chr7	105592670	CSF3	1440	0.15	trans
rs2072161	chr7	105662460	CSF3	1440	0.01	trans
rs849398	chr7	106524410	CSF3	1440	0.1	trans
rs7822021	chr8	8145522	CSF3	1440	2.971E-8	trans
rs7836064	chr8	8147998	CSF3	1440	0.08	trans
rs10108493	chr8	16448604	CSF3	1440	0.01	trans
rs2623858	chr8	68677367	CSF3	1440	0.13	trans
rs2623857	chr8	68677408	CSF3	1440	0.13	trans
rs6983345	chr8	90918219	CSF3	1440	0.16	trans
rs6989092	chr8	94989037	CSF3	1440	0.01	trans
rs11142899	chr9	74196408	CSF3	1440	0.16	trans
rs2082711	chr9	83109430	CSF3	1440	6.859E-6	trans
rs10993509	chr9	98071989	CSF3	1440	0.05	trans
rs7019048	chr9	102278601	CSF3	1440	0.02	trans
rs2151040	chr9	111364777	CSF3	1440	0	trans
rs11188623	chr10	97896966	CSF3	1440	0.11	trans
rs3814226	chr10	97920061	CSF3	1440	0.11	trans
rs3009929	chr10	121307427	CSF3	1440	0.09	trans
rs2912754	chr10	123261693	CSF3	1440	0.06	trans
rs16935169	chr11	18216966	CSF3	1440	0.17	trans
rs10893162	chr11	124076268	CSF3	1440	0.01	trans
rs11219545	chr11	124136438	CSF3	1440	0.01	trans
rs11219646	chr11	124279239	CSF3	1440	0.01	trans
rs2512874	chr11	131461291	CSF3	1440	1.54E-12	trans
rs985692	chr12	19309249	CSF3	1440	0.19	trans
rs1262052	chr12	55107102	CSF3	1440	0.15	trans
rs17223144	chr12	64718922	CSF3	1440	0.13	trans
rs1405500	chr12	79600640	CSF3	1440	0.09	trans
rs4143624	chr12	80947210	CSF3	1440	0.1	trans
rs3751163	chr12	121138984	CSF3	1440	0.11	trans
rs1019348	chr12	127402726	CSF3	1440	0.05	trans
rs7329574	chr13	92663432	CSF3	1440	2.234E-4	trans
rs8006993	chr14	33506969	CSF3	1440	0.09	trans
rs17101623	chr14	34085185	CSF3	1440	0	trans
rs1955728	chr14	39976063	CSF3	1440	0.11	trans
rs17103839	chr14	67491122	CSF3	1440	0.19	trans
rs17108711	chr14	71392731	CSF3	1440	0.03	trans
rs17093729	chr14	71552351	CSF3	1440	0.14	trans
rs1978163	chr14	71600636	CSF3	1440	0.02	trans
rs11846003	chr14	71602084	CSF3	1440	0.02	trans
rs17100048	chr14	101700617	CSF3	1440	0.03	trans
rs8028951	chr15	27187231	CSF3	1440	1.778E-5	trans
rs7172208	chr15	32994905	CSF3	1440	0.01	trans
rs16951575	chr15	68317450	CSF3	1440	0.07	trans
rs1559448	chr16	17530587	CSF3	1440	0.14	trans
rs8062326	chr16	19156015	CSF3	1440	0.11	trans
rs8060783	chr16	74544560	CSF3	1440	0.07	trans
rs231523	chr17	41953997	CSF3	1440	0.01	trans
rs2448755	chr18	65344801	CSF3	1440	0.18	trans
rs17196823	chr18	67270658	CSF3	1440	0.02	trans
rs16999774	chr19	23246399	CSF3	1440	0.08	trans
rs10425739	chr19	29582202	CSF3	1440	4.164E-7	trans
rs16962554	chr19	29590544	CSF3	1440	0.02	trans
rs6076051	chr20	23306825	CSF3	1440	0.19	trans
rs6076060	chr20	23345068	CSF3	1440	2.674E-7	trans
rs805944	chr20	38261717	CSF3	1440	0.13	trans
rs2148213	chr20	54798599	CSF3	1440	0	trans
rs458491	chr21	43366286	CSF3	1440	4.653E-5	trans
rs5915686	chrX	3969878	CSF3	1440	0.18	trans
rs5916432	chrX	3969940	CSF3	1440	0.18	trans
rs5916433	chrX	3970115	CSF3	1440	0.18	trans
rs16985093	chrX	8629830	CSF3	1440	0.06	trans
rs7054479	chrX	27852083	CSF3	1440	0	trans
rs16988033	chrX	27911766	CSF3	1440	0.02	trans
rs16997889	chrX	27923926	CSF3	1440	0.02	trans
rs1886581	chrX	68600054	CSF3	1440	0.04	trans
rs5977398	chrX	130127548	CSF3	1440	0.04	trans
rs12688226	chrX	141238619	CSF3	1440	0.05	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE	88	60	All SZGR 2.0 genes in this pathway
BIOCARTA GRANULOCYTES PATHWAY	14	9	All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM PATHWAY	29	24	All SZGR 2.0 genes in this pathway
BIOCARTA ERYTH PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA IL17 PATHWAY	17	12	All SZGR 2.0 genes in this pathway
BIOCARTA STEM PATHWAY	15	13	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION DN	30	25	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN	156	106	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN	44	30	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON	133	78	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN	59	32	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER	49	30	All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN	45	31	All SZGR 2.0 genes in this pathway
AUJLA IL22 AND IL17A SIGNALING	11	5	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN	216	143	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN	138	92	All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES	31	26	All SZGR 2.0 genes in this pathway
WALLACE JAK2 TARGETS UP	26	15	All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS	108	68	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3	162	80	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
WANG TNF TARGETS	24	17	All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP	121	70	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Gene Page: CSF3