Gene Page: CSNK1E

Summary ?
GeneID1454
SymbolCSNK1E
SynonymsCKIepsilon|HCKIE
Descriptioncasein kinase 1 epsilon
ReferenceMIM:600863|HGNC:HGNC:2453|Ensembl:ENSG00000213923|HPRD:02919|Vega:OTTHUMG00000151135
Gene typeprotein-coding
Map location22q13.1
Pascal p-value0.014
Sherlock p-value0.077
Fetal beta0.948
DMG1 (# studies)
eGeneHippocampus
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg047663772238713606CSNK1E1.03E-50.4660.013DMG:Wockner_2014
cg091978912238713447CSNK1E8.74E-5-0.2230.026DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TMBIM10.930.95
CYP2J20.900.93
ALDOC0.890.92
HADHB0.880.90
CLU0.880.92
PIR0.870.88
NDRG20.870.93
SNTA10.870.90
GRAMD30.860.91
PLEKHB10.860.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NKIRAS2-0.74-0.75
CRMP1-0.73-0.78
ZNF821-0.72-0.77
PJA1-0.72-0.75
DNAJC9-0.72-0.74
MPP3-0.72-0.78
TTLL1-0.72-0.75
ZWILCH-0.71-0.75
PPM1G-0.71-0.75
RTF1-0.71-0.79

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP9AKAP350 | AKAP450 | CG-NAP | HYPERION | KIAA0803 | MU-RMS-40.16A | PRKA9 | YOTIAOA kinase (PRKA) anchor protein (yotiao) 9-HPRD12270714 
ANKRD6DIVERSINankyrin repeat domain 6-HPRD,BioGRID12183362 
ARNTLBMAL1 | BMAL1c | JAP3 | MGC47515 | MOP3 | PASD3 | TIC | bHLHe5aryl hydrocarbon receptor nuclear translocator-like-HPRD,BioGRID11875063 
AXIN1AXIN | MGC52315axin 1Affinity Capture-Western
Phenotypic Suppression		BioGRID11884395 
AXIN1AXIN | MGC52315axin 1-HPRD11487578 |12000790 
CRY1PHLL1cryptochrome 1 (photolyase-like)-HPRD11875063 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)-HPRD,BioGRID11487578 |11818547 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER interacts with CSNK1E.BIND16009131 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
PER1MGC88021 | PER | RIGUI | hPERperiod homolog 1 (Drosophila)-HPRD,BioGRID10848614 |11865049 
PER3GIG13period homolog 3 (Drosophila)Affinity Capture-WesternBioGRID14701732 
PPP1R14ACPI-17 | CPI17 | PPP1INLprotein phosphatase 1, regulatory (inhibitor) subunit 14A-HPRD15003508 
RAD54BFSBP | RDH54RAD54 homolog B (S. cerevisiae)Two-hybridBioGRID16189514 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD9349507 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG HEDGEHOG SIGNALING PATHWAY 5642All SZGR 2.0 genes in this pathway
KEGG CIRCADIAN RHYTHM MAMMAL 1313All SZGR 2.0 genes in this pathway
PID BETA CATENIN DEG PATHWAY 1817All SZGR 2.0 genes in this pathway
PID CIRCADIAN PATHWAY 1615All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 4943All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 4835All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6643All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 5938All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 8150All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 5340All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 15993All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 8868All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 DN 4331All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 10063All SZGR 2.0 genes in this pathway
FIRESTEIN CTNNB1 PATHWAY AND PROLIFERATION 95All SZGR 2.0 genes in this pathway
FIRESTEIN CTNNB1 PATHWAY 3323All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 10265All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 10968All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 4738All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227151All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway