Gene Page: PIK3R6
Summary ?
| GeneID | 146850 |
| Symbol | PIK3R6 |
| Synonyms | C17orf38|HsT41028|p84 PIKAP|p87(PIKAP)|p87PIKAP |
| Description | phosphoinositide-3-kinase regulatory subunit 6 |
| Reference | MIM:611462|HGNC:HGNC:27101|Ensembl:ENSG00000276231|HPRD:12682|Vega:OTTHUMG00000132861 |
| Gene type | protein-coding |
| Map location | 17p13.1 |
| Pascal p-value | 0.335 |
| Fetal beta | 0.181 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg08697847 | 17 | 8771114 | PIK3R6 | 9.2E-5 | -0.314 | 0.027 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID TXA2PATHWAY | 57 | 43 | All SZGR 2.0 genes in this pathway |
| PID CXCR4 PATHWAY | 102 | 78 | All SZGR 2.0 genes in this pathway |
| PID PI3KCI PATHWAY | 49 | 40 | All SZGR 2.0 genes in this pathway |
| PID EPHA FWDPATHWAY | 34 | 29 | All SZGR 2.0 genes in this pathway |
| PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
| PID IL8 CXCR2 PATHWAY | 34 | 26 | All SZGR 2.0 genes in this pathway |
| PID IL8 CXCR1 PATHWAY | 28 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHOLIPID METABOLISM | 198 | 112 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | 31 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME PI METABOLISM | 48 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME GPVI MEDIATED ACTIVATION CASCADE | 31 | 25 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 25 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 28 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 208 | 138 | All SZGR 2.0 genes in this pathway |
| FOSTER TOLERANT MACROPHAGE DN | 409 | 268 | All SZGR 2.0 genes in this pathway |