Summary ?
GeneID1539
SymbolCYLC2
Synonyms-
Descriptioncylicin, basic protein of sperm head cytoskeleton 2
ReferenceMIM:604035|HGNC:HGNC:2583|Ensembl:ENSG00000155833|HPRD:04945|Vega:OTTHUMG00000020396
Gene typeprotein-coding
Map location9q31.1
Pascal p-value0.346
Fetal beta0.171

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
ExpressionMeta-analysis of gene expressionP value: 1.379 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
USP120.370.33
ARHGEF30.360.31
TASP10.350.31
TRPC10.350.31
CNTN30.340.35
AC012652.10.340.33
RIMBP20.340.33
AL031003.10.340.36
DLG20.340.34
AL133410.30.340.34
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TP53I13-0.24-0.23
IMPA2-0.23-0.22
ACAA2-0.23-0.19
NKAIN4-0.23-0.22
AQP5-0.23-0.22
RHOC-0.22-0.26
AC217773.2-0.22-0.22
H2AFJ-0.22-0.29
IL17RC-0.22-0.23
TRIP6-0.22-0.21

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005200structural constituent of cytoskeletonTAS7737358 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007283spermatogenesisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
XU HGF TARGETS REPRESSED BY AKT1 DN 9558All SZGR 2.0 genes in this pathway
SU TESTIS 7653All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181112All SZGR 2.0 genes in this pathway