Gene Page: C7orf60
Summary ?
| GeneID | 154743 |
| Symbol | C7orf60 |
| Synonyms | - |
| Description | chromosome 7 open reading frame 60 |
| Reference | HGNC:HGNC:26475|Ensembl:ENSG00000164603|HPRD:08108|Vega:OTTHUMG00000155233 |
| Gene type | protein-coding |
| Map location | 7q31.1 |
| Pascal p-value | 0.497 |
| TADA p-value | 0.009 |
| eGene | Anterior cingulate cortex BA24 Myers' cis & trans |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| C7orf60 | chr7 | 112461833 | T | C | NM_152556 | p.395Y>C | missense | Schizophrenia | DNM:Fromer_2014 | ||
| C7orf60 | chr7 | 112579790 | C | G | NM_152556 | p.6G>R | missense | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs843350 | chr3 | 183946273 | C7orf60 | 154743 | 0.12 | trans | ||
| rs16836102 | chr4 | 4716366 | C7orf60 | 154743 | 0.05 | trans | ||
| rs10248098 | 7 | 111636575 | C7orf60 | ENSG00000164603.7 | 1.55381E-6 | 0.04 | 943396 | gtex_brain_ba24 |
| rs34645464 | 7 | 111638306 | C7orf60 | ENSG00000164603.7 | 1.44782E-6 | 0.04 | 941665 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| LINSLEY MIR16 TARGETS | 206 | 127 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |