Gene Page: CYP2C9
Summary ?
GeneID | 1559 |
Symbol | CYP2C9 |
Synonyms | CPC9|CYP2C|CYP2C10|CYPIIC9|P450IIC9 |
Description | cytochrome P450 family 2 subfamily C member 9 |
Reference | MIM:601130|HGNC:HGNC:2623|Ensembl:ENSG00000138109|HPRD:03084|Vega:OTTHUMG00000018805 |
Gene type | protein-coding |
Map location | 10q24 |
Pascal p-value | 0.691 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ARPP-21 | 0.80 | 0.85 |
TMEM145 | 0.77 | 0.77 |
SLC26A8 | 0.76 | 0.76 |
PARP2 | 0.74 | 0.73 |
SNX32 | 0.72 | 0.71 |
OR2W3 | 0.72 | 0.81 |
R3HDM1 | 0.72 | 0.79 |
ZFR2 | 0.71 | 0.78 |
CCDC64 | 0.71 | 0.74 |
C3orf62 | 0.71 | 0.69 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MT-CO2 | -0.58 | -0.54 |
AF347015.31 | -0.57 | -0.53 |
AF347015.8 | -0.57 | -0.53 |
AF347015.33 | -0.56 | -0.50 |
AF347015.26 | -0.56 | -0.53 |
AF347015.2 | -0.56 | -0.52 |
MT-CYB | -0.55 | -0.51 |
AF347015.27 | -0.55 | -0.51 |
AF347015.15 | -0.55 | -0.51 |
AF347015.21 | -0.53 | -0.52 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005506 | iron ion binding | IEA | - | |
GO:0020037 | heme binding | IEA | - | |
GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IEA | - | |
GO:0009055 | electron carrier activity | IEA | - | |
GO:0018675 | (S)-limonene 6-monooxygenase activity | IEA | - | |
GO:0018676 | (S)-limonene 7-monooxygenase activity | IEA | - | |
GO:0033767 | 4-hydroxyacetophenone monooxygenase activity | IEA | - | |
GO:0046872 | metal ion binding | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0055114 | oxidation reduction | NAS | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005792 | microsome | TAS | 2827463 |3032244 | |
GO:0005789 | endoplasmic reticulum membrane | IEA | - | |
GO:0005783 | endoplasmic reticulum | NAS | - | |
GO:0016020 | membrane | IEA | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG ARACHIDONIC ACID METABOLISM | 58 | 36 | All SZGR 2.0 genes in this pathway |
KEGG LINOLEIC ACID METABOLISM | 29 | 16 | All SZGR 2.0 genes in this pathway |
KEGG RETINOL METABOLISM | 64 | 37 | All SZGR 2.0 genes in this pathway |
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | 70 | 44 | All SZGR 2.0 genes in this pathway |
KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
REACTOME XENOBIOTICS | 16 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | 51 | 34 | All SZGR 2.0 genes in this pathway |
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 70 | 50 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
WANG CLIM2 TARGETS UP | 269 | 146 | All SZGR 2.0 genes in this pathway |
VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | All SZGR 2.0 genes in this pathway |
SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN | 179 | 97 | All SZGR 2.0 genes in this pathway |
WOO LIVER CANCER RECURRENCE DN | 80 | 54 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA CLASSES DN | 210 | 141 | All SZGR 2.0 genes in this pathway |
FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |