Gene Page: ADRBK2

Summary ?
GeneID157
SymbolADRBK2
SynonymsBARK2|GRK3
Descriptionadrenergic, beta, receptor kinase 2
ReferenceMIM:109636|HGNC:HGNC:290|Ensembl:ENSG00000100077|HPRD:00183|Vega:OTTHUMG00000150280
Gene typeprotein-coding
Map location22q12.1
Pascal p-value0.756
Sherlock p-value0.972
Fetal beta-0.801
eGeneAnterior cingulate cortex BA24
Cerebellar Hemisphere
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2712089chr224080273ADRBK21570.01trans
rs1437904chr2133830789ADRBK21570.15trans
rs13418573chr2205418512ADRBK21570.1trans
rs17032578chr33555893ADRBK21570.15trans
rs1155107chr326843376ADRBK21570.01trans
rs17029291chr332402138ADRBK21572.647E-6trans
rs830202chr3165654796ADRBK21570.19trans
rs6843749chr484847249ADRBK21570.11trans
rs16901958chr544776555ADRBK21570.08trans
rs750544chr551749054ADRBK21570trans
rs17146240chr5119522933ADRBK21570.08trans
rs17146261chr5119534252ADRBK21570.08trans
rs2807510chr673090536ADRBK21570.17trans
rs4617108chr749423831ADRBK21570.02trans
rs7894597chr109384581ADRBK21570.17trans
rs12253630chr1074768923ADRBK21570.16trans
rs7078127chr1074847633ADRBK21570.1trans
rs12569493chr1074886042ADRBK21570trans
rs16930362chr1074890320ADRBK21570trans
rs2271904chr1074894374ADRBK21570.1trans
rs7092445chr1074921991ADRBK21570.03trans
rs12256576chr1074934313ADRBK21570.19trans
rs1867565chr1074977780ADRBK21570.14trans
rs11000557chr1074987393ADRBK21570.15trans
rs16915029chr1075001994ADRBK21570.07trans
rs16930466chr1075007587ADRBK21570.13trans
rs11000607chr1075089777ADRBK21570.07trans
rs6480700chr1075101689ADRBK21570.16trans
rs16930573chr1075167645ADRBK21570.2trans
rs12571454chr1075208954ADRBK21570.03trans
rs7949511chr1167938847ADRBK21570.11trans
rs7935070chr1167982990ADRBK21570.17trans
rs1324669chr13107872446ADRBK21574.751E-5trans
snp_a-22120610ADRBK21570.18trans
rs3742829chr1473489267ADRBK21570.09trans
rs8055506chr1613661723ADRBK21570.08trans
rs16962446chr1613694936ADRBK21570.13trans
rs3924428chr1625934820ADRBK21570.13trans
rs16958358chr1755502410ADRBK21570.17trans
rs6098023chr2053113740ADRBK21570trans
rs6015314chr2057167224ADRBK21570.05trans
rs12157904chr2237982011ADRBK21570.13trans
rs17145698chrX40218345ADRBK21570.13trans
rs17328938chrX99519447ADRBK21570.17trans
rs1335267chrX99570223ADRBK21570.17trans
rs57607862225395342ADRBK2ENSG00000100077.101.08E-60.03-565474gtex_brain_ba24
rs57607932225400511ADRBK2ENSG00000100077.101.146E-60.03-560305gtex_brain_ba24
rs38598642225402318ADRBK2ENSG00000100077.101.388E-60.03-558498gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RNF1230.910.90
NISCH0.900.90
SLC45A10.900.89
AP1B10.900.89
ATP6AP10.900.90
ATP13A20.890.90
ABCB90.890.87
AP2A20.890.89
SLC27A40.890.90
FAM134A0.880.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.67-0.63
AP002478.3-0.62-0.61
MT-CO2-0.62-0.57
AF347015.31-0.62-0.56
AF347015.8-0.61-0.56
NOSTRIN-0.61-0.56
GNG11-0.60-0.59
AF347015.33-0.59-0.53
MT-CYB-0.59-0.53
AF347015.2-0.58-0.50

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0004703G-protein coupled receptor kinase activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0047696beta-adrenergic receptor kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS8427589 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005886plasma membraneIDA18029348 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG OLFACTORY TRANSDUCTION 38985All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 5743All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 4332All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 8554All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 9264All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195138All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 11Q23 DELETION 2318All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
BUCKANOVICH T LYMPHOCYTE HOMING ON TUMOR UP 2411All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176110All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway