Gene Page: CYP2E1

Summary ?
GeneID1571
SymbolCYP2E1
SynonymsCPE1|CYP2E|P450-J|P450C2E
Descriptioncytochrome P450 family 2 subfamily E member 1
ReferenceMIM:124040|HGNC:HGNC:2631|Ensembl:ENSG00000130649|HPRD:11813|Vega:OTTHUMG00000019322
Gene typeprotein-coding
Map location10q26.3
Pascal p-value0.079
Sherlock p-value0.717
Fetal beta-0.661
eGeneCortex
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10857731chr10135328359CYP2E115710.14cis
rs633915chr1182682157CYP2E115710.15trans
rs621071chr1182682810CYP2E115710trans
rs941907210135310445CYP2E1ENSG00000130649.51.02E-60-23465gtex_brain_putamen_basal
rs185445810135313815CYP2E1ENSG00000130649.51.02E-60-20095gtex_brain_putamen_basal
rs941898210135320622CYP2E1ENSG00000130649.51.02E-60-13288gtex_brain_putamen_basal
rs941898410135322356CYP2E1ENSG00000130649.52.506E-60-11554gtex_brain_putamen_basal
rs708307310135322956CYP2E1ENSG00000130649.55.052E-90-10954gtex_brain_putamen_basal
rs709263410135322977CYP2E1ENSG00000130649.55.052E-90-10933gtex_brain_putamen_basal
rs653760910135323084CYP2E1ENSG00000130649.55.052E-90-10826gtex_brain_putamen_basal
rs791113910135323525CYP2E1ENSG00000130649.54.576E-90-10385gtex_brain_putamen_basal
rs707745710135324370CYP2E1ENSG00000130649.55.052E-90-9540gtex_brain_putamen_basal
rs941898710135324409CYP2E1ENSG00000130649.52.483E-60-9501gtex_brain_putamen_basal
rs709620310135324505CYP2E1ENSG00000130649.55.052E-90-9405gtex_brain_putamen_basal
rs709632110135324536CYP2E1ENSG00000130649.55.052E-90-9374gtex_brain_putamen_basal
rs1085773010135326822CYP2E1ENSG00000130649.54.311E-90-7088gtex_brain_putamen_basal
rs941907910135326985CYP2E1ENSG00000130649.51.016E-70-6925gtex_brain_putamen_basal
rs1077668510135327317CYP2E1ENSG00000130649.55.052E-90-6593gtex_brain_putamen_basal
rs158193410135327410CYP2E1ENSG00000130649.55.052E-90-6500gtex_brain_putamen_basal
rs709537910135328532CYP2E1ENSG00000130649.55.052E-90-5378gtex_brain_putamen_basal
rs709599610135328948CYP2E1ENSG00000130649.55.052E-90-4962gtex_brain_putamen_basal
rs1181562310135329133CYP2E1ENSG00000130649.55.027E-90-4777gtex_brain_putamen_basal
rs202604710135329616CYP2E1ENSG00000130649.52.149E-60-4294gtex_brain_putamen_basal
rs75194510135329939CYP2E1ENSG00000130649.51.974E-90-3971gtex_brain_putamen_basal
rs75194610135330104CYP2E1ENSG00000130649.52.701E-120-3806gtex_brain_putamen_basal
rs941899010135337966CYP2E1ENSG00000130649.56.895E-704056gtex_brain_putamen_basal
rs207067310135340567CYP2E1ENSG00000130649.55.563E-706657gtex_brain_putamen_basal
rs153682810135342315CYP2E1ENSG00000130649.52.315E-608405gtex_brain_putamen_basal
rs819277010135342644CYP2E1ENSG00000130649.53.089E-608734gtex_brain_putamen_basal
rs819277610135348187CYP2E1ENSG00000130649.53.366E-6014277gtex_brain_putamen_basal
rs248025710135352509CYP2E1ENSG00000130649.52.871E-6018599gtex_brain_putamen_basal
rs436351310135355534CYP2E1ENSG00000130649.51.779E-7021624gtex_brain_putamen_basal
rs424052210135355557CYP2E1ENSG00000130649.51.7E-7021647gtex_brain_putamen_basal
rs153682610135357239CYP2E1ENSG00000130649.53.352E-7023329gtex_brain_putamen_basal
rs302051310135364915CYP2E1ENSG00000130649.51.076E-6031005gtex_brain_putamen_basal
rs298778510135365003CYP2E1ENSG00000130649.56.522E-7031093gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TNFSF130.870.81
GPR1430.860.82
PRDX60.840.76
GJB60.840.81
TAPBPL0.830.78
SNTA10.820.81
TMBIM10.810.81
NDRG20.810.84
AGXT2L10.810.82
EPHX10.800.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BLMH-0.57-0.69
RTF1-0.57-0.68
NOVA2-0.56-0.70
RNF40-0.56-0.69
HEATR5B-0.56-0.67
NKIRAS2-0.56-0.71
PJA1-0.56-0.69
NOL4-0.55-0.70
BASP1-0.55-0.68
TOPBP1-0.55-0.66

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ARACHIDONIC ACID METABOLISM 5836All SZGR 2.0 genes in this pathway
KEGG LINOLEIC ACID METABOLISM 2916All SZGR 2.0 genes in this pathway
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 7044All SZGR 2.0 genes in this pathway
KEGG DRUG METABOLISM CYTOCHROME P450 7247All SZGR 2.0 genes in this pathway
BIOCARTA NUCLEARRS PATHWAY 1512All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME XENOBIOTICS 1611All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 5134All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E 8944All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 6643All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 6438All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 6442All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP 7958All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 8667All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254164All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
TUOMISTO TUMOR SUPPRESSION BY COL13A1 DN 1711All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 4929All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 14175All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 9356All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL DN 127All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176110All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210141All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA POOR SURVIVAL 169All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5 3022All SZGR 2.0 genes in this pathway