Gene Page: CYP4B1

Summary ?
GeneID1580
SymbolCYP4B1
SynonymsCYPIVB1|P-450HP
Descriptioncytochrome P450 family 4 subfamily B member 1
ReferenceMIM:124075|HGNC:HGNC:2644|Ensembl:ENSG00000142973|HPRD:00491|Vega:OTTHUMG00000007984
Gene typeprotein-coding
Map location1p33
Pascal p-value0.175
Fetal beta-0.118
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17131472chr191962966CYP4B115800.06trans
rs3762382chr1198128858CYP4B115800.12trans
rs6546473chr269260356CYP4B115800.07trans
rs1566993chr2117105059CYP4B115800.13trans
rs10050805chr530805352CYP4B115800.17trans
rs9381511chr612931447CYP4B115800.07trans
rs6455226chr667930295CYP4B115800trans
rs7081666chr1047673800CYP4B115800.1trans
rs10733768chr1052667246CYP4B115800.02trans
rs1159612chr1085329057CYP4B115800.01trans
rs10879027chr1270237156CYP4B115800.02trans
rs16958302chr1657647432CYP4B115800.06trans
rs6506551chr188167049CYP4B115800.18trans
rs4805564chr1930911055CYP4B115800.04trans
rs6095741chr2048666589CYP4B115802.007E-8trans
rs5915713chrX4077883CYP4B115800.02trans
rs5991662chrX43335796CYP4B115800trans
rs1545676chrX93530472CYP4B115801.266E-4trans
rs242163chrX132311662CYP4B115800.06trans
rs17340148chrX138648246CYP4B115800trans
rs10521801chrX138732866CYP4B115800.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CSRP20.830.55
AP000926.20.820.71
SLA0.800.78
C8orf790.790.73
PTPRO0.790.75
POU3F20.770.68
DOPEY20.770.70
KRT310.770.72
VSTM2L0.760.75
SEMA3C0.760.74
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HEPN1-0.54-0.68
HLA-F-0.53-0.62
RENBP-0.53-0.67
AIFM3-0.53-0.66
CLU-0.53-0.62
TSC22D4-0.52-0.67
AP003117.1-0.52-0.58
FAH-0.52-0.66
HSD17B14-0.52-0.67
BDH2-0.52-0.69

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 5134All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349157All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 14993All SZGR 2.0 genes in this pathway
SAENZ DETOX PATHWAY AND CARCINOGENESIS DN 1311All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 10873All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 2316All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE UP 3823All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 10369All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 5334All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN 8558All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 8452All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 13483All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403240All SZGR 2.0 genes in this pathway