Gene Page: CYP19A1

Summary ?
GeneID1588
SymbolCYP19A1
SynonymsARO|ARO1|CPV1|CYAR|CYP19|CYPXIX|P-450AROM
Descriptioncytochrome P450 family 19 subfamily A member 1
ReferenceMIM:107910|HGNC:HGNC:2594|Ensembl:ENSG00000137869|HPRD:00488|Vega:OTTHUMG00000131747
Gene typeprotein-coding
Map location15q21.1
Pascal p-value8.712E-4
Fetal beta-0.268

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs23057071551569410null1.555CYP19A1null


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EML10.960.87
AFF30.950.91
GPR120.940.87
FAT40.940.91
FAM117B0.930.90
FAM59A0.930.87
SSBP20.930.89
SEZ60.930.90
BACH20.930.89
DACT10.920.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.65-0.75
HEPN1-0.61-0.78
LHPP-0.61-0.61
C5orf53-0.61-0.75
AIFM3-0.60-0.80
HLA-F-0.60-0.79
TNFSF12-0.60-0.59
FBXO2-0.60-0.65
HSD17B14-0.60-0.80
TSC22D4-0.59-0.81

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG STEROID HORMONE BIOSYNTHESIS 5530All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D 3523All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 5134All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
REACTOME ENDOGENOUS STEROLS 1510All SZGR 2.0 genes in this pathway
REACTOME STEROID HORMONES 2921All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456228All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN 7657All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP 6745All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN 4638All SZGR 2.0 genes in this pathway
SU PLACENTA 3018All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR GAMMA RADIATION 1513All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN 4531All SZGR 2.0 genes in this pathway
MATZUK STEROIDOGENESIS 76All SZGR 2.0 genes in this pathway
MATZUK MALE REPRODUCTION SERTOLI 2823All SZGR 2.0 genes in this pathway
MATZUK SPERMATOGONIA 2417All SZGR 2.0 genes in this pathway
ALONSO METASTASIS DN 2617All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 9058All SZGR 2.0 genes in this pathway
SUMI HNF4A TARGETS 3414All SZGR 2.0 genes in this pathway