Gene Page: CYP21A1P
Summary ?
| GeneID | 1590 |
| Symbol | CYP21A1P |
| Synonyms | CYP21A|CYP21P|P450c21A |
| Description | cytochrome P450 family 21 subfamily A member 1, pseudogene |
| Reference | HGNC:HGNC:2599|Ensembl:ENSG00000204338| |
| Gene type | pseudo |
| Map location | 6p21.3 |
| Pascal p-value | 6.605E-10 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs201571916 | 6 | 32611196 | CYP21A1P | ENSG00000204338.4 | 5.79672E-7 | 0.03 | 637783 | gtex_brain_putamen_basal |
| rs9282208 | 6 | 32676682 | CYP21A1P | ENSG00000204338.4 | 4.0153E-7 | 0.03 | 703269 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SERTAD4 | 0.91 | 0.80 |
| FOXO1 | 0.90 | 0.54 |
| TSPAN9 | 0.89 | 0.66 |
| C10orf41 | 0.89 | 0.40 |
| PBX3 | 0.88 | 0.59 |
| FAM40B | 0.88 | 0.45 |
| RXRG | 0.87 | 0.22 |
| DLX6 | 0.86 | 0.59 |
| GPR149 | 0.85 | 0.58 |
| IKZF1 | 0.85 | 0.56 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CHPT1 | -0.26 | -0.19 |
| PTH1R | -0.24 | -0.28 |
| AF347015.31 | -0.24 | -0.43 |
| C5orf53 | -0.24 | -0.31 |
| CDADC1 | -0.24 | 0.09 |
| COPZ2 | -0.24 | -0.36 |
| MYL3 | -0.23 | -0.43 |
| MT-CO2 | -0.23 | -0.44 |
| FXYD1 | -0.23 | -0.44 |
| S100B | -0.23 | -0.36 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | All SZGR 2.0 genes in this pathway |