Gene Page: TDRD5
Summary ?
| GeneID | 163589 |
| Symbol | TDRD5 |
| Synonyms | TUDOR3 |
| Description | tudor domain containing 5 |
| Reference | HGNC:HGNC:20614|Ensembl:ENSG00000162782|HPRD:15483|Vega:OTTHUMG00000035259 |
| Gene type | protein-coding |
| Map location | 1q25.2 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hypothalamus Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:McCarthy_2014 | Whole Exome Sequencing analysis | Whole exome sequencing of 57 trios with sporadic or familial schizophrenia. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TDRD5 | chr1 | 179561962 | G | A | NM_001199085 | p.G71D | missense SNV | N | B | Schizophrenia | DNM:McCarthy_2014 |
| TDRD5 | chr1 | 179564848 | C | G | NM_001199085 NM_001199089 NM_001199091 NM_173533 | . . . . | silent silent silent silent | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs3765547 | 1 | 179542602 | TDRD5 | ENSG00000162782.11 | 2.77573E-7 | 0 | -18146 | gtex_brain_ba24 |
| rs10913821 | 1 | 179549586 | TDRD5 | ENSG00000162782.11 | 2.30215E-7 | 0 | -11162 | gtex_brain_ba24 |
| rs744446 | 1 | 179558051 | TDRD5 | ENSG00000162782.11 | 1.23866E-8 | 0 | -2697 | gtex_brain_ba24 |
| rs913514 | 1 | 179558801 | TDRD5 | ENSG00000162782.11 | 5.63822E-8 | 0 | -1947 | gtex_brain_ba24 |
| rs1999068 | 1 | 179560718 | TDRD5 | ENSG00000162782.11 | 7.00156E-9 | 0 | -30 | gtex_brain_ba24 |
| rs76644806 | 1 | 179561154 | TDRD5 | ENSG00000162782.11 | 5.94096E-9 | 0 | 406 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |