Gene Page: ACE

Summary ?
GeneID1636
SymbolACE
SynonymsACE1|CD143|DCP|DCP1|ICH|MVCD3
Descriptionangiotensin I converting enzyme
ReferenceMIM:106180|HGNC:HGNC:2707|Ensembl:ENSG00000159640|HPRD:00108|Vega:OTTHUMG00000154927
Gene typeprotein-coding
Map location17q23.3
Pascal p-value0.004
Fetal beta-0.53

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.089 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004180carboxypeptidase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008241peptidyl-dipeptidase activityIDA1320019 |1668266 |2849100 
|17077303 
GO:0008241peptidyl-dipeptidase activityIEA-
GO:0008241peptidyl-dipeptidase activityISS11303049 
GO:0008237metallopeptidase activityIDA1320019 |1668266 |2849100 
|17077303 
GO:0008237metallopeptidase activityIEA-
GO:0008237metallopeptidase activityISS-
GO:0008144drug bindingIDA1320019 
GO:0008233peptidase activityIEA-
GO:0031404chloride ion bindingIDA12540854 
GO:0031711bradykinin receptor bindingIPI17077303 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensinIC1668266 
GO:0002005angiotensin catabolic process in bloodIC1668266 
GO:0001822kidney developmentIMP16116425 
GO:0006508proteolysisIEA-
GO:0008217regulation of blood pressureISS11303049 
GO:0042312regulation of vasodilationIC4322742 
GO:0014910regulation of smooth muscle cell migrationISS-
GO:0042447hormone catabolic processIDA7876104 
GO:0042447hormone catabolic processISS11303049 
GO:0019229regulation of vasoconstrictionIC1668266 
GO:0032943mononuclear cell proliferationIC7876104 
GO:0043171peptide catabolic processIDA4322742 
GO:0050482arachidonic acid secretionIDA17077303 
GO:0060218hemopoietic stem cell differentiationIC7876104 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA1668266 |4322742 
GO:0005624membrane fractionIDA1668266 |2849100 
GO:0005768endosomeIDA17077303 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RENIN ANGIOTENSIN SYSTEM 1710All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 8565All SZGR 2.0 genes in this pathway
BIOCARTA ACE2 PATHWAY 137All SZGR 2.0 genes in this pathway
SA MMP CYTOKINE CONNECTION 159All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180101All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153100All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN 9057All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 2015All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 10361All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV 6243All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA 11477All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-272222281Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC