Gene Page: AP1G1

Summary ?
GeneID164
SymbolAP1G1
SynonymsADTG|CLAPG1
Descriptionadaptor related protein complex 1 gamma 1 subunit
ReferenceMIM:603533|HGNC:HGNC:555|Ensembl:ENSG00000166747|HPRD:04637|Vega:OTTHUMG00000176871
Gene typeprotein-coding
Map location16q23
Pascal p-value0.059
Sherlock p-value0.277
Fetal beta0.215
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg166666981671842293AP1G13.1E-8-0.0139.43E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17000249chr476031156AP1G11640.08trans
rs3217906chr124405803AP1G11640.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AFTPHFLJ20080 | FLJ23793 | MGC33965 | Nbla10388aftiphilin-HPRD14665628 
AP1B1ADTB1 | AP105A | BAM22 | CLAPB2adaptor-related protein complex 1, beta 1 subunit-HPRD,BioGRID9733768 
AP1G1ADTG | CLAPG1 | MGC18255adaptor-related protein complex 1, gamma 1 subunit-HPRD12042876 
AP1GBP1MGC104959 | SYNGAP1 gamma subunit binding protein 1-HPRD,BioGRID9653655 |10814529 
|12042876 
AP1M1AP47 | CLAPM2 | CLTNM | MU-1Aadaptor-related protein complex 1, mu 1 subunitAffinity Capture-WesternBioGRID10535737 
AP1M2AP1-mu2 | HSMU1B | MU-1B | MU1B | mu2adaptor-related protein complex 1, mu 2 subunit-HPRD,BioGRID10535737 
AP1S1AP19 | CLAPS1 | FLJ92436 | SIGMA1A | WUGSC:H_DJ0747G18.2adaptor-related protein complex 1, sigma 1 subunitThe gamma-1 and sigma-1A subunits of the AP-1 complex interact. This interaction was modeled on a demonstrated interaction between mouse gamma-1 and human sigma-1A.BIND15469849 
AP1S1AP19 | CLAPS1 | FLJ92436 | SIGMA1A | WUGSC:H_DJ0747G18.2adaptor-related protein complex 1, sigma 1 subunit-HPRD,BioGRID9733768 
AP1S2DC22 | MGC:1902 | MRX59 | SIGMA1Badaptor-related protein complex 1, sigma 2 subunit-HPRD,BioGRID9733768 
ARF1-ADP-ribosylation factor 1-HPRD,BioGRID11926829 
C4orf162C18 | GBAR | PRO0971chromosome 4 open reading frame 16C4orf16 (2c18) interacts with AP1G1 (gamma-1-adaptin).BIND15775984 
CLINT1CLINT | ENTH | EPN4 | EPNR | EPSINR | FLJ46753 | KIAA0171clathrin interactor 1-HPRD,BioGRID12429846 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD,BioGRID11451993 
DNERUNQ26 | betdelta/notch-like EGF repeat containing-HPRD11950833 
KIF13AFLJ27232 | bA500C11.2kinesin family member 13A-HPRD,BioGRID11106728 
MAP1AFLJ77111 | MAP1L | MTAP1Amicrotubule-associated protein 1A-HPRD10747088 |11418592 
NECAP1DKFZP566B183 | MGC131900NECAP endocytosis associated 1Affinity Capture-WesternBioGRID14665628 
NECAP2FLJ10420 | RP4-798A10.1NECAP endocytosis associated 2Affinity Capture-WesternBioGRID14665628 
RAB5ARAB5RAB5A, member RAS oncogene familyTwo-hybridBioGRID14665628 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1Reconstituted Complex
Two-hybrid		BioGRID12042876 |12505986 
SPTBHSpTB1spectrin, beta, erythrocytic-HPRD10477754 
SYP-synaptophysinTwo-hybridBioGRID12498786 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG LYSOSOME 12183All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 105All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 2112All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 6031All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 9161All SZGR 2.0 genes in this pathway
REACTOME LYSOSOME VESICLE BIOGENESIS 2311All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 5327All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 2819All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 6447All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION 8159All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway