Gene Page: WBP2NL
Summary ?
| GeneID | 164684 |
| Symbol | WBP2NL |
| Synonyms | GRAMD7|PAWP |
| Description | WBP2 N-terminal like |
| Reference | MIM:610981|HGNC:HGNC:28389|Ensembl:ENSG00000183066|HPRD:14512|Vega:OTTHUMG00000151270 |
| Gene type | protein-coding |
| Map location | 22q13.2 |
| Pascal p-value | 2.262E-8 |
| Sherlock p-value | 0.683 |
| Fetal beta | 0.141 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6002556 | 22 | 42343773 | WBP2NL | ENSG00000183066.10 | 3.834E-7 | 0.01 | -50956 | gtex_brain_ba24 |
| rs5996092 | 22 | 42344408 | WBP2NL | ENSG00000183066.10 | 9.834E-7 | 0.01 | -50321 | gtex_brain_ba24 |
| rs5996094 | 22 | 42347060 | WBP2NL | ENSG00000183066.10 | 9.032E-7 | 0.01 | -47669 | gtex_brain_ba24 |
| rs7285557 | 22 | 42348790 | WBP2NL | ENSG00000183066.10 | 8.574E-7 | 0.01 | -45939 | gtex_brain_ba24 |
| rs4822069 | 22 | 42351481 | WBP2NL | ENSG00000183066.10 | 2.281E-7 | 0.01 | -43248 | gtex_brain_ba24 |
| rs6002561 | 22 | 42359204 | WBP2NL | ENSG00000183066.10 | 2.28E-7 | 0.01 | -35525 | gtex_brain_ba24 |
| rs4822072 | 22 | 42360833 | WBP2NL | ENSG00000183066.10 | 2.091E-6 | 0.01 | -33896 | gtex_brain_ba24 |
| rs6519298 | 22 | 42364997 | WBP2NL | ENSG00000183066.10 | 8.753E-7 | 0.01 | -29732 | gtex_brain_ba24 |
| rs739292 | 22 | 42368857 | WBP2NL | ENSG00000183066.10 | 1.3E-6 | 0.01 | -25872 | gtex_brain_ba24 |
| rs5758527 | 22 | 42375761 | WBP2NL | ENSG00000183066.10 | 1.424E-6 | 0.01 | -18968 | gtex_brain_ba24 |
| rs5751195 | 22 | 42380001 | WBP2NL | ENSG00000183066.10 | 1.3E-6 | 0.01 | -14728 | gtex_brain_ba24 |
| rs739294 | 22 | 42381726 | WBP2NL | ENSG00000183066.10 | 1.715E-6 | 0.01 | -13003 | gtex_brain_ba24 |
| rs133293 | 22 | 42382797 | WBP2NL | ENSG00000183066.10 | 1.287E-6 | 0.01 | -11932 | gtex_brain_ba24 |
| rs133294 | 22 | 42382805 | WBP2NL | ENSG00000183066.10 | 9.275E-7 | 0.01 | -11924 | gtex_brain_ba24 |
| rs6519301 | 22 | 42385967 | WBP2NL | ENSG00000183066.10 | 9.275E-7 | 0.01 | -8762 | gtex_brain_ba24 |
| rs133300 | 22 | 42389839 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | -4890 | gtex_brain_ba24 |
| rs133301 | 22 | 42390093 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | -4636 | gtex_brain_ba24 |
| rs133303 | 22 | 42395242 | WBP2NL | ENSG00000183066.10 | 1.086E-6 | 0.01 | 513 | gtex_brain_ba24 |
| rs133305 | 22 | 42395960 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 1231 | gtex_brain_ba24 |
| rs133306 | 22 | 42396150 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 1421 | gtex_brain_ba24 |
| rs133307 | 22 | 42396568 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 1839 | gtex_brain_ba24 |
| rs5758537 | 22 | 42397042 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 2313 | gtex_brain_ba24 |
| rs71751842 | 22 | 42398849 | WBP2NL | ENSG00000183066.10 | 1.16E-6 | 0.01 | 4120 | gtex_brain_ba24 |
| rs129855 | 22 | 42399325 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 4596 | gtex_brain_ba24 |
| rs129856 | 22 | 42399396 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 4667 | gtex_brain_ba24 |
| rs129857 | 22 | 42399686 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 4957 | gtex_brain_ba24 |
| rs6002571 | 22 | 42400416 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 5687 | gtex_brain_ba24 |
| rs133313 | 22 | 42401749 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 7020 | gtex_brain_ba24 |
| rs133314 | 22 | 42401841 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 7112 | gtex_brain_ba24 |
| rs133317 | 22 | 42402386 | WBP2NL | ENSG00000183066.10 | 1.39E-6 | 0.01 | 7657 | gtex_brain_ba24 |
| rs133318 | 22 | 42402480 | WBP2NL | ENSG00000183066.10 | 1.303E-6 | 0.01 | 7751 | gtex_brain_ba24 |
| rs133320 | 22 | 42403853 | WBP2NL | ENSG00000183066.10 | 1.136E-6 | 0.01 | 9124 | gtex_brain_ba24 |
| rs133321 | 22 | 42405322 | WBP2NL | ENSG00000183066.10 | 1.762E-6 | 0.01 | 10593 | gtex_brain_ba24 |
| rs133322 | 22 | 42405659 | WBP2NL | ENSG00000183066.10 | 2.045E-6 | 0.01 | 10930 | gtex_brain_ba24 |
| rs133323 | 22 | 42405922 | WBP2NL | ENSG00000183066.10 | 1.762E-6 | 0.01 | 11193 | gtex_brain_ba24 |
| rs133324 | 22 | 42406371 | WBP2NL | ENSG00000183066.10 | 1.762E-6 | 0.01 | 11642 | gtex_brain_ba24 |
| rs133325 | 22 | 42406820 | WBP2NL | ENSG00000183066.10 | 1.762E-6 | 0.01 | 12091 | gtex_brain_ba24 |
| rs133326 | 22 | 42406885 | WBP2NL | ENSG00000183066.10 | 1.762E-6 | 0.01 | 12156 | gtex_brain_ba24 |
| rs133327 | 22 | 42407689 | WBP2NL | ENSG00000183066.10 | 1.757E-6 | 0.01 | 12960 | gtex_brain_ba24 |
| rs133328 | 22 | 42408079 | WBP2NL | ENSG00000183066.10 | 1.755E-6 | 0.01 | 13350 | gtex_brain_ba24 |
| rs133330 | 22 | 42409456 | WBP2NL | ENSG00000183066.10 | 1.748E-6 | 0.01 | 14727 | gtex_brain_ba24 |
| rs2413664 | 22 | 42413978 | WBP2NL | ENSG00000183066.10 | 1.482E-6 | 0.01 | 19249 | gtex_brain_ba24 |
| rs133335 | 22 | 42416056 | WBP2NL | ENSG00000183066.10 | 2.289E-6 | 0.01 | 21327 | gtex_brain_ba24 |
| rs133336 | 22 | 42416303 | WBP2NL | ENSG00000183066.10 | 1.146E-6 | 0.01 | 21574 | gtex_brain_ba24 |
| rs133339 | 22 | 42416987 | WBP2NL | ENSG00000183066.10 | 2.606E-6 | 0.01 | 22258 | gtex_brain_ba24 |
| rs133340 | 22 | 42417687 | WBP2NL | ENSG00000183066.10 | 1.219E-6 | 0.01 | 22958 | gtex_brain_ba24 |
| rs133346 | 22 | 42420855 | WBP2NL | ENSG00000183066.10 | 3.759E-7 | 0.01 | 26126 | gtex_brain_ba24 |
| rs133347 | 22 | 42423645 | WBP2NL | ENSG00000183066.10 | 2.373E-6 | 0.01 | 28916 | gtex_brain_ba24 |
| rs133349 | 22 | 42428727 | WBP2NL | ENSG00000183066.10 | 2.789E-6 | 0.01 | 33998 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |