Gene Page: SNX31
Summary ?
| GeneID | 169166 |
| Symbol | SNX31 |
| Synonyms | - |
| Description | sorting nexin 31 |
| Reference | HGNC:HGNC:28605|Ensembl:ENSG00000174226|HPRD:17545|Vega:OTTHUMG00000164725 |
| Gene type | protein-coding |
| Map location | 8q22.3 |
| Pascal p-value | 0.858 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Gulsuner_2013 | Whole Exome Sequencing analysis | 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents. | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNX31 | chr8 | 101624302 | C | G | NM_152628 | p.179L>F | missense | Schizophrenia | DNM:Gulsuner_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7370564 | 0 | SNX31 | 169166 | 0.17 | trans | |||
| rs1786345 | 8 | 101674751 | SNX31 | ENSG00000174226.4 | 7.191E-7 | 0 | 892 | gtex_brain_putamen_basal |
| rs1693551 | 8 | 101675584 | SNX31 | ENSG00000174226.4 | 1.183E-8 | 0 | 59 | gtex_brain_putamen_basal |
| rs1786342 | 8 | 101676363 | SNX31 | ENSG00000174226.4 | 1.12E-6 | 0 | -720 | gtex_brain_putamen_basal |
| rs7831859 | 8 | 101676642 | SNX31 | ENSG00000174226.4 | 1.422E-7 | 0 | -999 | gtex_brain_putamen_basal |
| rs2978098 | 8 | 101676675 | SNX31 | ENSG00000174226.4 | 3.513E-7 | 0 | -1032 | gtex_brain_putamen_basal |
| rs1693567 | 8 | 101677386 | SNX31 | ENSG00000174226.4 | 1.221E-8 | 0 | -1743 | gtex_brain_putamen_basal |
| rs11357738 | 8 | 101677428 | SNX31 | ENSG00000174226.4 | 5.923E-8 | 0 | -1785 | gtex_brain_putamen_basal |
| rs1693568 | 8 | 101677693 | SNX31 | ENSG00000174226.4 | 1.183E-8 | 0 | -2050 | gtex_brain_putamen_basal |
| rs1693571 | 8 | 101678349 | SNX31 | ENSG00000174226.4 | 1.183E-8 | 0 | -2706 | gtex_brain_putamen_basal |
| rs2978101 | 8 | 101679224 | SNX31 | ENSG00000174226.4 | 1.183E-8 | 0 | -3581 | gtex_brain_putamen_basal |
| rs2978102 | 8 | 101679411 | SNX31 | ENSG00000174226.4 | 1.183E-8 | 0 | -3768 | gtex_brain_putamen_basal |
| rs35251069 | 8 | 101679888 | SNX31 | ENSG00000174226.4 | 2.935E-6 | 0 | -4245 | gtex_brain_putamen_basal |
| rs1693560 | 8 | 101680292 | SNX31 | ENSG00000174226.4 | 1.183E-8 | 0 | -4649 | gtex_brain_putamen_basal |
| rs1693562 | 8 | 101681102 | SNX31 | ENSG00000174226.4 | 3.218E-6 | 0 | -5459 | gtex_brain_putamen_basal |
| rs1786341 | 8 | 101681104 | SNX31 | ENSG00000174226.4 | 8.111E-7 | 0 | -5461 | gtex_brain_putamen_basal |
| rs13271135 | 8 | 101681976 | SNX31 | ENSG00000174226.4 | 3.001E-6 | 0 | -6333 | gtex_brain_putamen_basal |
| rs28723022 | 8 | 101682073 | SNX31 | ENSG00000174226.4 | 2.358E-6 | 0 | -6430 | gtex_brain_putamen_basal |
| rs1786340 | 8 | 101682471 | SNX31 | ENSG00000174226.4 | 3.007E-6 | 0 | -6828 | gtex_brain_putamen_basal |
| rs33986428 | 8 | 101685422 | SNX31 | ENSG00000174226.4 | 2.606E-6 | 0 | -9779 | gtex_brain_putamen_basal |
| rs1786337 | 8 | 101685470 | SNX31 | ENSG00000174226.4 | 1.829E-6 | 0 | -9827 | gtex_brain_putamen_basal |
| rs879391 | 8 | 101685694 | SNX31 | ENSG00000174226.4 | 1.896E-6 | 0 | -10051 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON | 132 | 82 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |