Summary ?
GeneID170692
SymbolADAMTS18
SynonymsADAMTS21|KNO2|MMCAT
DescriptionADAM metallopeptidase with thrombospondin type 1 motif 18
ReferenceMIM:607512|HGNC:HGNC:17110|Ensembl:ENSG00000140873|HPRD:06333|Vega:OTTHUMG00000137619
Gene typeprotein-coding
Map location16q23
Pascal p-value0.75
Fetal beta-1.377
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Gulsuner_2013Whole Exome Sequencing analysis155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
ADAMTS18chr1677356337TCNM_199355p.687K>EmissenseSchizophreniaDNM:Gulsuner_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17392743chr154764240ADAMTS181706920.01trans
rs17572651chr1218943612ADAMTS181706920trans
rs16829545chr2151977407ADAMTS181706922.102E-7trans
rs3845734chr2171125572ADAMTS181706920.14trans
rs7584986chr2184111432ADAMTS181706921.76E-8trans
rs11934631chr454405096ADAMTS181706920.12trans
rs747592chr54883605ADAMTS181706920trans
rs17762315chr576807576ADAMTS181706920.06trans
rs6892587chr5133085407ADAMTS181706920.08trans
rs1368303chr5147672388ADAMTS181706920.01trans
rs13191953chr624151042ADAMTS181706920.13trans
rs2393316chr1059333070ADAMTS181706920.02trans
rs6574467chr1479179744ADAMTS181706920.08trans
rs10146003chr1479191170ADAMTS181706920.08trans
rs16955618chr1529937543ADAMTS181706927.751E-19trans
rs3743068chr1579047284ADAMTS181706920.04trans
rs13180211677389088ADAMTS18ENSG00000140873.112.681E-70.0279923gtex_brain_ba24
rs8669241677389312ADAMTS18ENSG00000140873.116.756E-70.0279699gtex_brain_ba24
rs105144151677390128ADAMTS18ENSG00000140873.112.046E-70.0278883gtex_brain_ba24
rs13926071677390996ADAMTS18ENSG00000140873.112.051E-70.0278015gtex_brain_ba24
rs13926081677391077ADAMTS18ENSG00000140873.112.051E-70.0277934gtex_brain_ba24
rs13926091677391114ADAMTS18ENSG00000140873.112.051E-70.0277897gtex_brain_ba24
rs25621121677391272ADAMTS18ENSG00000140873.113.444E-70.0277739gtex_brain_ba24
rs8911331677392867ADAMTS18ENSG00000140873.112.051E-70.0276144gtex_brain_ba24
rs8911341677393072ADAMTS18ENSG00000140873.112.119E-70.0275939gtex_brain_ba24
rs26509071677393207ADAMTS18ENSG00000140873.112.051E-70.0275804gtex_brain_ba24
rs8911361677393811ADAMTS18ENSG00000140873.112.248E-70.0275200gtex_brain_ba24
rs25621141677394134ADAMTS18ENSG00000140873.112.051E-70.0274877gtex_brain_ba24
rs575173521677394478ADAMTS18ENSG00000140873.113.601E-70.0274533gtex_brain_ba24
rs25621151677394592ADAMTS18ENSG00000140873.112.051E-70.0274419gtex_brain_ba24
rs9375841677395205ADAMTS18ENSG00000140873.112.051E-70.0273806gtex_brain_ba24
rs9375851677395259ADAMTS18ENSG00000140873.112.051E-70.0273752gtex_brain_ba24
rs19098021677395948ADAMTS18ENSG00000140873.112.051E-70.0273063gtex_brain_ba24
rs26509051677396431ADAMTS18ENSG00000140873.112.033E-70.0272580gtex_brain_ba24
rs26509061677396454ADAMTS18ENSG00000140873.112.033E-70.0272557gtex_brain_ba24
rs48886221677396849ADAMTS18ENSG00000140873.112.051E-70.0272162gtex_brain_ba24
rs26509081677396961ADAMTS18ENSG00000140873.113.444E-70.0272050gtex_brain_ba24
rs22466071677397167ADAMTS18ENSG00000140873.116.586E-70.0271844gtex_brain_ba24
rs25621171677397273ADAMTS18ENSG00000140873.112.052E-70.0271738gtex_brain_ba24
rs25621181677397321ADAMTS18ENSG00000140873.112.052E-70.0271690gtex_brain_ba24
rs13180211677389088ADAMTS18ENSG00000140873.114.035E-16079923gtex_brain_putamen_basal
rs8669241677389312ADAMTS18ENSG00000140873.114.237E-16079699gtex_brain_putamen_basal
rs80583331677389762ADAMTS18ENSG00000140873.111.736E-7079249gtex_brain_putamen_basal
rs105144151677390128ADAMTS18ENSG00000140873.115.83E-17078883gtex_brain_putamen_basal
rs105144161677390450ADAMTS18ENSG00000140873.112.106E-6078561gtex_brain_putamen_basal
rs607420961677390525ADAMTS18ENSG00000140873.112.106E-6078486gtex_brain_putamen_basal
rs24348981677390751ADAMTS18ENSG00000140873.112.106E-6078260gtex_brain_putamen_basal
rs13926071677390996ADAMTS18ENSG00000140873.115.854E-17078015gtex_brain_putamen_basal
rs13926081677391077ADAMTS18ENSG00000140873.115.854E-17077934gtex_brain_putamen_basal
rs13926091677391114ADAMTS18ENSG00000140873.115.854E-17077897gtex_brain_putamen_basal
rs25621121677391272ADAMTS18ENSG00000140873.115.854E-17077739gtex_brain_putamen_basal
rs15004831677391376ADAMTS18ENSG00000140873.111.239E-6077635gtex_brain_putamen_basal
rs25621111677392052ADAMTS18ENSG00000140873.112.105E-6076959gtex_brain_putamen_basal
rs26508901677392060ADAMTS18ENSG00000140873.112.105E-6076951gtex_brain_putamen_basal
rs8911331677392867ADAMTS18ENSG00000140873.115.854E-17076144gtex_brain_putamen_basal
rs8911341677393072ADAMTS18ENSG00000140873.115.371E-17075939gtex_brain_putamen_basal
rs26509071677393207ADAMTS18ENSG00000140873.115.854E-17075804gtex_brain_putamen_basal
rs2011593661677393808ADAMTS18ENSG00000140873.113.232E-12075203gtex_brain_putamen_basal
rs8911351677393810ADAMTS18ENSG00000140873.117.513E-11075201gtex_brain_putamen_basal
rs8911361677393811ADAMTS18ENSG00000140873.112.925E-14075200gtex_brain_putamen_basal
rs25621141677394134ADAMTS18ENSG00000140873.115.854E-17074877gtex_brain_putamen_basal
rs575173521677394478ADAMTS18ENSG00000140873.119.035E-17074533gtex_brain_putamen_basal
rs25621151677394592ADAMTS18ENSG00000140873.115.854E-17074419gtex_brain_putamen_basal
rs26509031677394939ADAMTS18ENSG00000140873.112.111E-6074072gtex_brain_putamen_basal
rs9375841677395205ADAMTS18ENSG00000140873.115.854E-17073806gtex_brain_putamen_basal
rs9375851677395259ADAMTS18ENSG00000140873.115.854E-17073752gtex_brain_putamen_basal
rs19098021677395948ADAMTS18ENSG00000140873.115.854E-17073063gtex_brain_putamen_basal
rs26509041677396307ADAMTS18ENSG00000140873.112.105E-6072704gtex_brain_putamen_basal
rs26509051677396431ADAMTS18ENSG00000140873.115.852E-17072580gtex_brain_putamen_basal
rs26509061677396454ADAMTS18ENSG00000140873.115.852E-17072557gtex_brain_putamen_basal
rs574710971677396578ADAMTS18ENSG00000140873.111.856E-16072433gtex_brain_putamen_basal
rs48886211677396712ADAMTS18ENSG00000140873.112.105E-6072299gtex_brain_putamen_basal
rs48886221677396849ADAMTS18ENSG00000140873.115.854E-17072162gtex_brain_putamen_basal
rs26509081677396961ADAMTS18ENSG00000140873.115.854E-17072050gtex_brain_putamen_basal
rs22466071677397167ADAMTS18ENSG00000140873.115.005E-16071844gtex_brain_putamen_basal
rs25621171677397273ADAMTS18ENSG00000140873.115.854E-17071738gtex_brain_putamen_basal
rs25621181677397321ADAMTS18ENSG00000140873.115.854E-17071690gtex_brain_putamen_basal
rs19487181677397899ADAMTS18ENSG00000140873.112.105E-6071112gtex_brain_putamen_basal
rs80443211677414815ADAMTS18ENSG00000140873.112.822E-7054196gtex_brain_putamen_basal
rs80589551677414960ADAMTS18ENSG00000140873.117.3E-8054051gtex_brain_putamen_basal
rs80507851677416119ADAMTS18ENSG00000140873.113.305E-7052892gtex_brain_putamen_basal
rs133382481677416830ADAMTS18ENSG00000140873.112.668E-7052181gtex_brain_putamen_basal
rs133382541677416858ADAMTS18ENSG00000140873.117.424E-8052153gtex_brain_putamen_basal
rs169455651677417029ADAMTS18ENSG00000140873.112.453E-7051982gtex_brain_putamen_basal
rs133322001677417039ADAMTS18ENSG00000140873.112.638E-7051972gtex_brain_putamen_basal
rs24549391677417054ADAMTS18ENSG00000140873.119.924E-13051957gtex_brain_putamen_basal
rs65644421677417735ADAMTS18ENSG00000140873.112.254E-6051276gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS DN 9751All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
MCGARVEY SILENCED BY METHYLATION IN COLON CANCER 4229All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway