SZGR2

Summary ?

GeneID	1741
Symbol	DLG3
Synonyms	MRX\|MRX90\|NEDLG\|PPP1R82\|SAP102\|XLMR
Description	discs large homolog 3
Reference	MIM:300189\|HGNC:HGNC:2902\|Ensembl:ENSG00000082458\|HPRD:02177\|Vega:OTTHUMG00000021778
Gene type	protein-coding
Map location	Xq13.1
Fetal beta	0.544
Support	PROTEIN CLUSTERING G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_PocklingtonH1 G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.7558

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		16192269 \|17353931
GO:0004385	guanylate kinase activity	NAS		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008285	negative regulation of cell proliferation	NAS		9188857
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005575	cellular_component	ND		-
GO:0005634	nucleus	IDA		18029348
GO:0005730	nucleolus	IDA		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANXA1	ANX1 \| LPC1	annexin A1	Affinity Capture-MS	BioGRID	17353931
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9188857
ATP2B2	PMCA2 \| PMCA2a \| PMCA2i	ATPase, Ca++ transporting, plasma membrane 2	Affinity Capture-Western	BioGRID	11274188
ATP2B4	ATP2B2 \| DKFZp686G08106 \| DKFZp686M088 \| MXRA1 \| PMCA4 \| PMCA4b \| PMCA4x	ATPase, Ca++ transporting, plasma membrane 4	-	HPRD,BioGRID	11274188
ATP2B4	ATP2B2 \| DKFZp686G08106 \| DKFZp686M088 \| MXRA1 \| PMCA4 \| PMCA4b \| PMCA4x	ATPase, Ca++ transporting, plasma membrane 4	PMCA4b interacts with SAP102. This interaction was modeled on a demonstrated interaction between human PMCA4b and SAP102 from rat and an unspecified source.	BIND	11274188
CAMK2A	CAMKA \| KIAA0968	calcium/calmodulin-dependent protein kinase II alpha	Affinity Capture-MS	BioGRID	17353931
CRIPT	HSPC139	cysteine-rich PDZ-binding protein	-	HPRD,BioGRID	11937501 \|12070168
CUL2	MGC131970	cullin 2	Affinity Capture-MS	BioGRID	17353931
DLG1	DKFZp761P0818 \| DKFZp781B0426 \| DLGH1 \| SAP97 \| dJ1061C18.1.1 \| hdlg	discs, large homolog 1 (Drosophila)	-	HPRD,BioGRID	12351654
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	10026200
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	Two-hybrid	BioGRID	9115257
DLGAP4	DAP4 \| KIAA0964 \| MGC131862 \| RP5-977B1.6 \| SAPAP4	discs, large (Drosophila) homolog-associated protein 4	-	HPRD	9115257
ERBB4	HER4 \| MGC138404 \| p180erbB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	-	HPRD,BioGRID	10725395 \|12175853
ERBB4	HER4 \| MGC138404 \| p180erbB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	ErbB-4 interacts with SAP-102.	BIND	10725395
EXOC3	SEC6 \| SEC6L1 \| Sec6p	exocyst complex component 3	Affinity Capture-Western	BioGRID	12738960
EXOC4	MGC27170 \| REC8 \| SEC8 \| SEC8L1 \| Sec8p	exocyst complex component 4	-	HPRD,BioGRID	12738960
EXOC7	2-5-3p \| DKFZp686J04253 \| EX070 \| EXO70 \| EXOC1 \| Exo70p \| FLJ40965 \| FLJ46415 \| YJL085W	exocyst complex component 7	Reconstituted Complex	BioGRID	12738960
GDA	CYPIN \| GUANASE \| KIAA1258 \| MGC9982 \| NEDASIN	guanine deaminase	-	HPRD,BioGRID	10542258 \|10595517
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	-	HPRD	12070168
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	Affinity Capture-Western	BioGRID	9808460
GRIK5	EAA2 \| GRIK2 \| KA2	glutamate receptor, ionotropic, kainate 5	Affinity Capture-Western	BioGRID	9808460
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	in vitro in vivo Two-hybrid	BioGRID	9278515 \|11937501
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	-	HPRD	11937501 \|12070168
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	-	HPRD,BioGRID	11937501
GRIN2C	NMDAR2C \| NR2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	-	HPRD,BioGRID	11937501
GUCY1A2	GC-SA2 \| GUC1A2	guanylate cyclase 1, soluble, alpha 2	-	HPRD,BioGRID	11572861
HIST1H2BC	H2B.1 \| H2B/l \| H2BFL \| MGC104246 \| dJ221C16.3	histone cluster 1, H2bc	Affinity Capture-MS	BioGRID	17353931
KCNJ12	FLJ14167 \| IRK2 \| KCNJN1 \| Kir2.2 \| Kir2.2v \| hIRK \| hIRK1 \| hkir2.2x \| kcnj12x	potassium inwardly-rectifying channel, subfamily J, member 12	-	HPRD,BioGRID	15024025
KLHDC3	PEAS \| RP1-20C7.3 \| dJ20C7.3 \| hPEAS	kelch domain containing 3	Affinity Capture-MS	BioGRID	17353931
KRT31	HA1 \| Ha-1 \| KRTHA1 \| MGC138630 \| hHa1	keratin 31	Affinity Capture-MS	BioGRID	17353931
KRT34	HA4 \| Ha-4 \| KRTHA4 \| hHa4	keratin 34	Affinity Capture-MS	BioGRID	17353931
KRT35	HA5 \| Ha-5 \| KRTHA5 \| hHa5	keratin 35	Affinity Capture-MS	BioGRID	17353931
KRT82	HB2 \| Hb-2 \| KRTHB2	keratin 82	Affinity Capture-MS	BioGRID	17353931
KRT85	HB5 \| Hb-5 \| KRTHB5 \| hHb5	keratin 85	Affinity Capture-MS	BioGRID	17353931
LIN7A	LIN-7A \| LIN7 \| MALS-1 \| MGC148143 \| TIP-33 \| VELI1	lin-7 homolog A (C. elegans)	-	HPRD,BioGRID	9753324
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD,BioGRID	12713445
NLGN1	KIAA1070 \| MGC45115	neuroligin 1	Two-hybrid	BioGRID	9278515
NLGN2	KIAA1366	neuroligin 2	Two-hybrid	BioGRID	9278515
NLGN3	ASPGX1 \| AUTSX1 \| HNL3 \| KIAA1480	neuroligin 3	-	HPRD,BioGRID	9278515
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	12576483
S100A3	S100E	S100 calcium binding protein A3	Affinity Capture-MS	BioGRID	17353931
SEMA4C	FLJ20369 \| KIAA1739 \| M-SEMA-F \| MGC126382 \| MGC126383 \| SEMACL1 \| SEMAF \| SEMAI	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	-	HPRD,BioGRID	11134026
SYNGAP1	DKFZp761G1421 \| KIAA1938 \| RASA1 \| RASA5 \| SYNGAP	synaptic Ras GTPase activating protein 1 homolog (rat)	-	HPRD,BioGRID	9581761

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	31	23	All SZGR 2.0 genes in this pathway
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	11	11	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP	380	215	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP	450	256	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP	133	78	All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS DN	24	13	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP	487	286	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP	292	168	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN	103	64	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP	225	139	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS DN	61	47	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP	166	105	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS UP	48	28	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN	428	246	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-136	604	610	1A	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-138	1781	1787	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	2021	2027	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2021	2027	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-143	208	214	1A	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-24	2708	2715	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-299-5p	984	990	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-326	1490	1496	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-363	270	276	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-369-3p	534	540	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	534	540	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	534	540	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-374	534	540	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	86	92	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-410	536	542	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
				hsa-miR-410	AAUAUAACACAGAUGGCCUGU
				hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-421	1790	1796	m8	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG
miR-500	268	275	1A,m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DLG3