Gene Page: DNMT1

Summary
GeneID  1786
Symbol  DNMT1
Synonyms  AIM|CXXC9|DNMT|FLJ16293|MCMT|MGC104992
Description  DNA (cytosine-5-)-methyltransferase 1
See related  HGNC:2976|MIM:126375|Ensembl:ENSG00000130816|HPRD:00532|
Locus tag  -
Gene type  protein-coding
Map location  19p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NCSTN0.850.82
VPS110.830.80
RNF260.820.83
TFG0.820.78
C16orf620.810.79
C7orf420.810.83
TMEM2140.810.80
PIGO0.800.77
GGCX0.790.77
ADIPOR10.790.74
Top 10 negatively co-expressed genes
AF347015.21-0.64-0.57
MT-CO2-0.56-0.51
AF347015.8-0.56-0.50
AF347015.18-0.56-0.56
AF347015.31-0.55-0.50
AC098691.2-0.54-0.50
MT-ATP8-0.53-0.52
AF347015.2-0.53-0.48
AF347015.27-0.52-0.48
MT-CYB-0.51-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003886DNA (cytosine-5-)-methyltransferase activityTAS8940105 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008134transcription factor bindingIEA-
GO:0008168methyltransferase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS10888872 
GO:0006306DNA methylationTAS10888872 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS8940105 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBX1CBX | HP1-BETA | HP1Hs-beta | HP1Hsbeta | M31 | MOD1 | p25betachromobox homolog 1 (HP1 beta homolog Drosophila )-HPRD,BioGRID12711675 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)Affinity Capture-WesternBioGRID12867029 
DMAP1DKFZp686L09142 | DNMAP1 | DNMTAP1 | EAF2 | FLJ11543 | KIAA1425 | SWC4DNA methyltransferase 1 associated protein 1-HPRD,BioGRID10888872 
DNMT1 interacts with DMAP1.BIND10888872 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alphahDNMT3a interacts with hDNMT1.BIND12145218 
-HPRD,BioGRID12145218 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 betaDNMT3B interacts with DNMT1.BIND15120635 
-HPRD,BioGRID12145218 
hDNMT3b interacts with hDNMT1.BIND12145218 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1Co-fractionationBioGRID10888886 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Co-fractionationBioGRID10888886 
-HPRD10615135 
HDAC2RPD3 | YAF1histone deacetylase 2DNMT1 interacts with HDAC2.BIND10888872 
-HPRD,BioGRID10888872 
MBD2DKFZp586O0821 | DMTase | NY-CO-41methyl-CpG binding domain protein 2-HPRD10947852 
MBD3-methyl-CpG binding domain protein 3-HPRD10947852 
PCNAMGC8367proliferating cell nuclear antigenAffinity Capture-Western
Reconstituted Complex		BioGRID9302295 |10888872 
|12354094 
DNMT1 is a PCNA-binding proteinBIND12171929 
-HPRD9302295 |12354094 
RARBHAP | NR1B2 | RRB2retinoic acid receptor, betaDNMT1 interacts with RARB (RAR-beta-2) gene promoter sequences.BIND15688037 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Rb interacts with hDnmt1.BIND11847125 
-HPRD,BioGRID10888886 
RGS6DKFZp313G1241 | FLJ43552 | GAP | MGC142132regulator of G-protein signaling 6Reconstituted ComplexBioGRID14734556 
SUV39H1KMT1A | MG44 | SUV39Hsuppressor of variegation 3-9 homolog 1 (Drosophila)-HPRD,BioGRID12711675 
TRIM27RFP | RNF76tripartite motif-containing 27Two-hybridBioGRID16169070 
TSG101TSG10 | VPS23tumor susceptibility gene 101-HPRD10888872 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 3424All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN 6439All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN 7550All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_DN 12267All SZGR genes in this pathway
OZANNE_AP1_TARGETS_UP 1811All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_UP 1512All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN 2521All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_DN 1710All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_16HR 4024All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
GAZIN_EPIGENETIC_SILENCING_BY_KRAS 2616All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_D 6844All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_DN 1513All SZGR genes in this pathway
PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP 5627All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-148/15248551A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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