Gene Page: DPYS

Summary ?
GeneID1807
SymbolDPYS
SynonymsDHP|DHPase
Descriptiondihydropyrimidinase
ReferenceMIM:613326|HGNC:HGNC:3013|Ensembl:ENSG00000147647|HPRD:01960|Vega:OTTHUMG00000164891
Gene typeprotein-coding
Map location8q22
Pascal p-value0.96
Fetal beta-2.651
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg170876408105479215DPYS2.57E-50.3490.017DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NIT10.880.84
MPI0.850.83
PDCD60.850.83
POLR2C0.840.77
APEH0.840.79
CAPZB0.830.81
WDR450.810.78
VRK30.810.76
PHKG20.810.78
ARFIP20.810.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.59-0.41
AF347015.18-0.58-0.44
MT-ATP8-0.54-0.40
AF347015.8-0.54-0.36
AF347015.2-0.54-0.35
MT-CO2-0.52-0.34
MT-CYB-0.51-0.35
AF347015.26-0.51-0.35
AF347015.31-0.50-0.35
AF347015.27-0.49-0.39

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PYRIMIDINE METABOLISM 9853All SZGR 2.0 genes in this pathway
KEGG BETA ALANINE METABOLISM 2216All SZGR 2.0 genes in this pathway
KEGG PANTOTHENATE AND COA BIOSYNTHESIS 169All SZGR 2.0 genes in this pathway
KEGG DRUG METABOLISM OTHER ENZYMES 5127All SZGR 2.0 genes in this pathway
REACTOME PYRIMIDINE CATABOLISM 125All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NUCLEOTIDES 7245All SZGR 2.0 genes in this pathway
REACTOME PYRIMIDINE METABOLISM 2413All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215132All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181112All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP 8550All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway