Gene Page: DRD5

Summary ?
GeneID1816
SymbolDRD5
SynonymsDBDR|DRD1B|DRD1L2
Descriptiondopamine receptor D5
ReferenceMIM:126453|HGNC:HGNC:3026|Ensembl:ENSG00000169676|HPRD:00542|Vega:OTTHUMG00000128489
Gene typeprotein-coding
Map location4p16.1
Pascal p-value0.039
Sherlock p-value0.761
Fetal beta-2.75
eGeneMyers' cis & trans
SupportDOPAMINE

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7142486chr1484504067DRD518160.09trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC110491.10.600.47
CRYBG30.600.51
CFTR0.580.45
DLC10.570.46
RHOQ0.560.44
ANO30.550.45
SLC1A20.550.39
TJP10.540.52
SCN4B0.540.42
ITGAV0.540.43
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RPL35-0.31-0.41
RPL36-0.30-0.41
RPS7-0.29-0.34
PFDN5-0.29-0.34
BCL7C-0.29-0.37
RPLP1-0.28-0.37
RPS14-0.28-0.34
FAU-0.28-0.36
RPL31-0.28-0.35
SCNM1-0.28-0.30

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001588dopamine receptor coupled via GsTASNeurotransmitter, dopamine (GO term level: 9)9457173 
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060158dopamine receptor, phospholipase C activating pathwayTASdopamine (GO term level: 10)9457173 
GO:0007268synaptic transmissionNASneuron, Synap, Neurotransmitter (GO term level: 6)7727453 
GO:0007191dopamine receptor, adenylate cyclase activating pathwayIDAdopamine (GO term level: 12)1826762 
GO:0001963synaptic transmission, dopaminergicNASneuron, Synap, Neurotransmitter, dopamine (GO term level: 8)11036203 
GO:0007190activation of adenylate cyclase activityTAS9457173 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
GO:0006800oxygen and reactive oxygen species metabolic processIDA16352863 
GO:0006874cellular calcium ion homeostasisTAS9457173 
GO:0033861negative regulation of NAD(P)H oxidase activityIDA16352863 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIDA10531415 |11500503 
GO:0005887integral to plasma membraneNAS1826762 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 3833All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 14296All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 8550All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293119All SZGR 2.0 genes in this pathway