Gene Page: DRG2
Summary ?
| GeneID | 1819 |
| Symbol | DRG2 |
| Synonyms | - |
| Description | developmentally regulated GTP binding protein 2 |
| Reference | MIM:602986|HGNC:HGNC:3030|Ensembl:ENSG00000108591|HPRD:04286|Vega:OTTHUMG00000059399 |
| Gene type | protein-coding |
| Map location | 17p11.2 |
| Pascal p-value | 6.125E-8 |
| Sherlock p-value | 0.209 |
| eGene | Cerebellar Hemisphere Cerebellum Cortex Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PPT1 | 0.70 | 0.70 |
| ATP6AP2 | 0.70 | 0.76 |
| PGK1 | 0.69 | 0.69 |
| MRS2 | 0.69 | 0.69 |
| ADIPOR1 | 0.67 | 0.74 |
| PEBP1 | 0.67 | 0.71 |
| SRPRB | 0.67 | 0.67 |
| PKM2 | 0.67 | 0.68 |
| UBE2E2 | 0.66 | 0.70 |
| SNX21 | 0.66 | 0.65 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.41 | -0.27 |
| AL022328.1 | -0.40 | -0.35 |
| FAM159B | -0.40 | -0.45 |
| C17orf84 | -0.40 | -0.33 |
| AC098691.2 | -0.39 | -0.31 |
| AC120053.1 | -0.38 | -0.41 |
| AC135724.1 | -0.38 | -0.36 |
| NSBP1 | -0.38 | -0.39 |
| KCNMB3 | -0.37 | -0.33 |
| EIF5B | -0.36 | -0.36 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| HORIUCHI WTAP TARGETS DN | 310 | 188 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| ODONNELL METASTASIS UP | 82 | 58 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS DN | 211 | 119 | All SZGR 2.0 genes in this pathway |