Gene Page: DVL1
Summary ?
| GeneID | 1855 |
| Symbol | DVL1 |
| Synonyms | DRS2|DVL|DVL1L1|DVL1P1 |
| Description | dishevelled segment polarity protein 1 |
| Reference | MIM:601365|HGNC:HGNC:3084|Ensembl:ENSG00000107404|HPRD:03220|Vega:OTTHUMG00000003069 |
| Gene type | protein-coding |
| Map location | 1p36 |
| Pascal p-value | 0.58 |
| Sherlock p-value | 0.462 |
| Fetal beta | -0.39 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0047 |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| DVL1 | chr1 | 1274965 | G | A | NM_004421 NM_004421 | . p.351R>W | splice missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | - | |
| GO:0003674 | molecular_function | ND | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 14750955 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016055 | Wnt receptor signaling pathway | IEA | - | |
| GO:0007242 | intracellular signaling cascade | IEA | - | |
| GO:0009653 | anatomical structure morphogenesis | TAS | 8817329 | |
| GO:0007507 | heart development | TAS | 8817329 | |
| GO:0007275 | multicellular organismal development | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005737 | cytoplasm | NAS | - | |
| GO:0005737 | cytoplasm | TAS | 9192851 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ARRB1 | ARB1 | ARR1 | arrestin, beta 1 | - | HPRD,BioGRID | 11742073 |
| ATN1 | B37 | D12S755E | DRPLA | NOD | atrophin 1 | Two-hybrid | BioGRID | 10332026 |
| AXIN1 | AXIN | MGC52315 | axin 1 | Affinity Capture-Western | BioGRID | 10428961 |
| AXIN1 | AXIN | MGC52315 | axin 1 | - | HPRD | 9482734 |10330403 |
| BRD7 | BP75 | CELTIX1 | NAG4 | bromodomain containing 7 | - | HPRD | 12941796 |
| CSNK1D | HCKID | casein kinase 1, delta | - | HPRD,BioGRID | 11818547 |
| CSNK1E | HCKIE | MGC10398 | casein kinase 1, epsilon | - | HPRD,BioGRID | 11487578 |11818547 |
| CSNK2A1 | CK2A1 | CKII | casein kinase 2, alpha 1 polypeptide | - | HPRD,BioGRID | 10806215 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | - | HPRD,BioGRID | 10806215 |
| CXXC4 | IDAX | MGC149872 | CXXC finger 4 | - | HPRD | 11113207 |
| DAAM1 | FLJ41657 | KIAA0666 | dishevelled associated activator of morphogenesis 1 | - | HPRD | 11779461 |
| DAB2 | DOC-2 | DOC2 | FLJ26626 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | Reconstituted Complex | BioGRID | 12805222 |
| DIXDC1 | CCD1 | KIAA1735 | DIX domain containing 1 | - | HPRD | 15262978 |
| DVL1 | DVL | MGC54245 | dishevelled, dsh homolog 1 (Drosophila) | - | HPRD,BioGRID | 10330181 |
| DVL3 | KIAA0208 | dishevelled, dsh homolog 3 (Drosophila) | - | HPRD,BioGRID | 10330181 |
| EPS8 | - | epidermal growth factor receptor pathway substrate 8 | - | HPRD,BioGRID | 10581192 |
| FRAT1 | FLJ97193 | frequently rearranged in advanced T-cell lymphomas | - | HPRD,BioGRID | 10428961 |
| GSK3B | - | glycogen synthase kinase 3 beta | - | HPRD | 10428961 |
| HECW1 | KIAA0322 | NEDL1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | - | HPRD,BioGRID | 14684739 |
| SMAD1 | BSP1 | JV4-1 | JV41 | MADH1 | MADR1 | SMAD family member 1 | Reconstituted Complex | BioGRID | 12650946 |
| SMAD2 | JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 | SMAD family member 2 | - | HPRD,BioGRID | 12650946 |
| SMAD3 | DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 | SMAD family member 3 | Reconstituted Complex Two-hybrid | BioGRID | 12650946 |
| SMAD4 | DPC4 | JIP | MADH4 | SMAD family member 4 | Reconstituted Complex | BioGRID | 12650946 |
| SMAD7 | CRCS3 | FLJ16482 | MADH7 | MADH8 | SMAD family member 7 | Reconstituted Complex | BioGRID | 12650946 |
| USP13 | ISOT3 | IsoT-3 | ubiquitin specific peptidase 13 (isopeptidase T-3) | Two-hybrid | BioGRID | 16169070 |
| VANGL1 | LPP2 | MGC5338 | STB2 | STBM2 | vang-like 1 (van gogh, Drosophila) | - | HPRD | 15456783 |
| VANGL2 | KIAA1215 | LPP1 | LTAP | MGC119403 | MGC119404 | STB1 | STBM | STBM1 | vang-like 2 (van gogh, Drosophila) | - | HPRD | 12490194 |