Gene Page: APLNR

Summary ?
GeneID187
SymbolAPLNR
SynonymsAGTRL1|APJ|APJR|HG11
Descriptionapelin receptor
ReferenceMIM:600052|HGNC:HGNC:339|Ensembl:ENSG00000134817|HPRD:02503|Vega:OTTHUMG00000167021
Gene typeprotein-coding
Map location11q12
Pascal p-value0.013
Sherlock p-value0.268
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12656577chr528079168APLNR1870.11trans
rs4078278chr1035107679APLNR1870.04trans
rs94181290APLNR1870.18trans
rs12254965chr10127297037APLNR1870.08trans
rs16979927chr2055019249APLNR1870.09trans
rs6632445chrX35981375APLNR1870.12trans
rs6632450chrX35993453APLNR1870.12trans
rs6629027chrX36007613APLNR1870.12trans
rs5973565chrX36067171APLNR1870.12trans
rs7060495chrX36100343APLNR1870.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT30.800.83
SCRG10.780.81
B2M0.780.81
PSMB90.780.80
KLRC30.770.80
S100A160.770.80
PSMB80.760.79
MT1G0.760.80
TLCD10.750.81
MT1E0.750.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HEATR5B-0.68-0.74
CKAP5-0.68-0.75
MCM3AP-0.68-0.74
PDXDC1-0.67-0.71
ZRANB1-0.67-0.72
ANKRD17-0.67-0.71
USP34-0.66-0.73
TOPBP1-0.66-0.73
POLR3A-0.66-0.73
EIF4ENIF1-0.66-0.71

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM6 4632All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN 3624All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 8757All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 7451All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN 4232All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP 6643All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN 4833All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE E2 2821All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 DN 5132All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 2515All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
KINNEY DNMT1 METHYLATION TARGETS 146All SZGR 2.0 genes in this pathway