SZGR2

Summary ?

GeneID	1870
Symbol	E2F2
Synonyms	E2F-2
Description	E2F transcription factor 2
Reference	MIM:600426\|HGNC:HGNC:3114\|Ensembl:ENSG00000007968\|HPRD:02692\|Vega:OTTHUMG00000003223
Gene type	protein-coding
Map location	1p36
Pascal p-value	0.502
Fetal beta	2.731
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg02992252	1	23857546	E2F2	3.136E-4	-0.347	0.04	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Two-hybrid	BioGRID	16169070
BRD2	D6S113E \| DKFZp686N0336 \| FLJ31942 \| FSH \| FSRG1 \| KIAA9001 \| NAT \| RING3 \| RNF3	bromodomain containing 2	-	HPRD,BioGRID	10965846 \|12145330
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	E2F2 interacts with the Cdc25A promoter region.	BIND	10766737
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	E2F2 interacts with the Cdc6 promoter region.	BIND	10766737
CDK3	-	cyclin-dependent kinase 3	-	HPRD,BioGRID	8846921 \|11733001
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	E2F2 interacts with the E2F1 promoter region.	BIND	10766737
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with the E2F2 promoter.	BIND	15861133
EAPP	BM036 \| C14orf11 \| FLJ20578 \| MGC4957	E2F-associated phosphoprotein	E2F2 interacts with EAPP.	BIND	15716352
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	Two-hybrid	BioGRID	12411495
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	E2F2 interacts with a molecule expressed by Gene FHL2. The precise molecular variant of FHL2 involved in this interaction is not specified.	BIND	12411495
GAB2	KIAA0571	GRB2-associated binding protein 2	The Gab2 promoter region interacts with E2F2.	BIND	15574337
JMY	FLJ37870 \| MGC163496	junction-mediating and regulatory protein	E2F2 interacts with the JMY promoter.	BIND	15706352
MT1G	MGC12386 \| MT1 \| MT1K	metallothionein 1G	E2F2 interacts with the MT1G promoter.	BIND	15735762
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	E2F2 interacts with the B-myb promoter region.	BIND	10766737
PPP1R13B	ASPP1 \| KIAA0771 \| p53BP2-like \| p85	protein phosphatase 1, regulatory (inhibitor) subunit 13B	E2F2 interacts with the PPP1R13B (ASPP1) promoter.	BIND	15706352
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	E2F-2 interacts with pRb.	BIND	8246996
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	12502741
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	E2F1 interacts with pRb.	BIND	8246996
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	pRB interacts with E2F-2.	BIND	15949438
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	E2F2 interacts with the p107 promoter region.	BIND	10766737
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	RBL2 (p130) interacts with the E2F2 promoter.	BIND	15861133
RNF144A	KIAA0161 \| RNF144 \| UBCE7IP4	ring finger protein 144A	Two-hybrid	BioGRID	12411495
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	E2F2 interacts with RYBP.	BIND	12411495
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	Affinity Capture-Western Two-hybrid	BioGRID	12411495
SETD8	KMT5A \| PR-Set7 \| SET07 \| SET8	SET domain containing (lysine methyltransferase) 8	E2F2 interacts with SET 07.	BIND	12411495
SETD8	KMT5A \| PR-Set7 \| SET07 \| SET8	SET domain containing (lysine methyltransferase) 8	Two-hybrid	BioGRID	12411495
SP1	-	Sp1 transcription factor	-	HPRD	8657141 \|8657142 \|9694791
SPIB	SPI-B	Spi-B transcription factor (Spi-1/PU.1 related)	Two-hybrid	BioGRID	12748276
TFDP1	DP1 \| DRTF1 \| Dp-1	transcription factor Dp-1	-	HPRD	7739537 \|8755520
TFDP2	DP2 \| Dp-2	transcription factor Dp-2 (E2F dimerization partner 2)	-	HPRD	7739537 \|8755520
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	E2F2 interacts with the TP53BP2 (ASPP2) promoter.	BIND	15706352
TP53INP1	DKFZp434M1317 \| FLJ22139 \| SIP \| TP53DINP1 \| TP53INP1A \| TP53INP1B \| Teap \| p53DINP1	tumor protein p53 inducible nuclear protein 1	E2F2 interacts with the TP53INP1 promoter.	BIND	15706352
UXT	ART-27	ubiquitously-expressed transcript	E2F2 interacts with the UXT chromatin.	BIND	11799066
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	-	HPRD	12411495

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
SA G1 AND S PHASES	15	10	All SZGR 2.0 genes in this pathway
SA REG CASCADE OF CYCLIN EXPR	13	7	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	11	5	All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION	81	45	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	36	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN	244	153	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP	269	146	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN	176	104	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN	165	104	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN	103	64	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP	52	40	All SZGR 2.0 genes in this pathway
REN BOUND BY E2F	61	40	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL	293	160	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ZHANG GATA6 TARGETS DN	64	46	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN	105	67	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN	238	145	All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP	107	59	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S	147	76	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP	211	131	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN	72	52	All SZGR 2.0 genes in this pathway
LE NEURONAL DIFFERENTIATION DN	19	16	All SZGR 2.0 genes in this pathway

Gene Page: E2F2