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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: E2F3

Summary

GeneID

1871

Symbol

E2F3

Synonyms

DKFZp686C18211|E2F-3|KIAA0075|MGC104598

Description

E2F transcription factor 3

Locus tag

RP1-177P22.2

Gene type

protein-coding

Map location

6p22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.033

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003700

transcription factor activity

IEA

GO:0003700

transcription factor activity

TAS

8246996

GO:0005515

protein binding

IPI

17438371

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006367

transcription initiation from RNA polymerase II promoter

TAS

8246996

GO:0006350

transcription

IEA

GO:0007049

cell cycle

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005654

nucleoplasm

EXP

9190208

GO:0005667

transcription factor complex

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	E2F3 (E2F-3) interacts with the BIRC5 (survivin) promoter.	BIND	15271987
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	E2F3 interacts with the Cdc2 promoter.	BIND	10766737
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	E2F3 interacts with the Cdc25A promoter.	BIND	10766737
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	E2F3 interacts with the Cdc6 promoter.	BIND	10766737
CDK3	-	cyclin-dependent kinase 3	-	HPRD,BioGRID	8846921 \|11733001
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Two-hybrid	BioGRID	12748276
EAPP	BM036 \| C14orf11 \| FLJ20578 \| MGC4957	E2F-associated phosphoprotein	E2F3 interacts with EAPP.	BIND	15716352
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	Two-hybrid	BioGRID	12411495
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	E2F3 interacts with a molecule expressed by Gene FHL2. The precise molecular variant of FHL2 involved in this interaction is not specified.	BIND	12411495
GAB2	KIAA0571	GRB2-associated binding protein 2	The Gab2 promoter region interacts with E2F3.	BIND	15574337
JMY	FLJ37870 \| MGC163496	junction-mediating and regulatory protein	E2F3 interacts with the JMY promoter.	BIND	15706352
MGA	FLJ12634 \| KIAA0518 \| MAD5 \| MXD5	MAX gene associated	Two-hybrid	BioGRID	12748276
MSH2	COCA1 \| FCC1 \| HNPCC \| HNPCC1 \| LCFS2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	E2F3 interacts with the MSH2 promoter.	BIND	11799067
MT1G	MGC12386 \| MT1 \| MT1K	metallothionein 1G	E2F3 interacts with the MT1G promoter.	BIND	15735762
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	E2F3 interacts with the B-myb promoter region.	BIND	10766737
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	Two-hybrid	BioGRID	12748276
PKIB	FLJ23817 \| PRKACN2	protein kinase (cAMP-dependent, catalytic) inhibitor beta	Two-hybrid	BioGRID	12748276
PPP1R13B	ASPP1 \| KIAA0771 \| p53BP2-like \| p85	protein phosphatase 1, regulatory (inhibitor) subunit 13B	E2F3 interacts with the PPP1R13B (ASPP1) promoter.	BIND	15706352
RNF144A	KIAA0161 \| RNF144 \| UBCE7IP4	ring finger protein 144A	Two-hybrid	BioGRID	12411495
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	Affinity Capture-Western Two-hybrid	BioGRID	12411495
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	E2F3 interacts with RYBP.	BIND	12411495
SP1	-	Sp1 transcription factor	-	HPRD	8657141
SPIB	SPI-B	Spi-B transcription factor (Spi-1/PU.1 related)	Two-hybrid	BioGRID	12748276
TEAD3	DTEF-1 \| ETFR-1 \| TEAD5 \| TEF-5 \| TEF5	TEA domain family member 3	Two-hybrid	BioGRID	12748276
TFDP1	DP1 \| DRTF1 \| Dp-1	transcription factor Dp-1	-	HPRD	7739537 \|8755520
TFDP2	DP2 \| Dp-2	transcription factor Dp-2 (E2F dimerization partner 2)	-	HPRD	7739537 \|8755520
TFE3	RCCP2 \| TFEA \| bHLHe33	transcription factor binding to IGHM enhancer 3	-	HPRD,BioGRID	12748276
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	E2F3 interacts with the TP53BP2 (ASPP2) promoter.	BIND	15706352
TP53INP1	DKFZp434M1317 \| FLJ22139 \| SIP \| TP53DINP1 \| TP53INP1A \| TP53INP1B \| Teap \| p53DINP1	tumor protein p53 inducible nuclear protein 1	E2F3 interacts with the TP53INP1 promoter.	BIND	15706352
UXT	ART-27	ubiquitously-expressed transcript	E2F3 interacts with the UXT chromatin.	BIND	11799066
WNK1	KDP \| KIAA0344 \| PHA2C \| PRKWNK1 \| PSK	WNK lysine deficient protein kinase 1	Two-hybrid	BioGRID	12748276
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	-	HPRD	12411495

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CELL_CYCLE	128	84	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER	70	56	All SZGR genes in this pathway
KEGG_GLIOMA	65	56	All SZGR genes in this pathway
KEGG_PROSTATE_CANCER	89	75	All SZGR genes in this pathway
KEGG_MELANOMA	71	57	All SZGR genes in this pathway
KEGG_BLADDER_CANCER	42	33	All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA	73	59	All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER	84	67	All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER	54	47	All SZGR genes in this pathway
PID_E2F_PATHWAY	74	48	All SZGR genes in this pathway
PID_MYC_ACTIV_PATHWAY	79	62	All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY	137	94	All SZGR genes in this pathway
PID_RB_1PATHWAY	65	46	All SZGR genes in this pathway
REACTOME_CELL_CYCLE	421	253	All SZGR genes in this pathway
REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION	29	17	All SZGR genes in this pathway
REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	44	24	All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC	325	185	All SZGR genes in this pathway
REACTOME_G1_PHASE	38	23	All SZGR genes in this pathway
REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX	11	5	All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION	81	45	All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES	137	79	All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES	172	98	All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES	81	50	All SZGR genes in this pathway
REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX	65	36	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH	103	64	All SZGR genes in this pathway
REACTOME_DNA_REPLICATION	192	110	All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP	137	94	All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP	294	178	All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP	372	227	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN	1375	806	All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP	29	20	All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_DN	49	33	All SZGR genes in this pathway
KONG_E2F3_TARGETS	97	58	All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL	330	217	All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL	330	215	All SZGR genes in this pathway
GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION	14	14	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
OXFORD_RALA_OR_RALB_TARGETS_UP	48	23	All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1	229	137	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP	121	71	All SZGR genes in this pathway
COURTOIS_SENESCENCE_TRIGGERS	6	5	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED	100	68	All SZGR genes in this pathway
GOTTWEIN_TARGETS_OF_KSHV_MIR_K12_11	63	45	All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER	100	62	All SZGR genes in this pathway
REN_BOUND_BY_E2F	61	40	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_DN	123	86	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP	178	111	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2	163	113	All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D1	18	13	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN	318	220	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP	148	96	All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP	566	371	All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP	648	398	All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1	91	75	All SZGR genes in this pathway
LU_TUMOR_ANGIOGENESIS_UP	25	22	All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP	105	75	All SZGR genes in this pathway
DANG_MYC_TARGETS_UP	143	100	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE	335	193	All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP	221	135	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN	336	211	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE	317	190	All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN	882	538	All SZGR genes in this pathway
DUAN_PRDM5_TARGETS	79	52	All SZGR genes in this pathway
RAFFEL_VEGFA_TARGETS_UP	9	8	All SZGR genes in this pathway
KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES	275	155	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY	1839	928	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	3180	3186	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	3180	3186	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-124/506	418	424	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	418	424	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	1185	1192	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1185	1192	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	2039	2045	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	2039	2045	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-140	1740	1747	1A,m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-141/200a	2603	2610	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-145	2029	2035	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152	2037	2043	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497	2491	2498	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	1786	1792	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	1824	1831	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-194	3176	3182	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-200bc/429	2857	2863	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-21	564	570	1A	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	564	570	1A	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-24*	3057	3064	1A,m8	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-25/32/92/363/367	272	278	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-5p	870	876	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-34/449	2730	2737	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-342	1252	1258	m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-370	1111	1117	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-378	1429	1435	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-378	1429	1435	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-433-3p	107	114	1A,m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-448	1785	1792	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-495	3174	3180	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	3125	3131	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-500	1880	1886	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-503	2492	2498	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.