SZGR2

Summary ?

GeneID	1871
Symbol	E2F3
Synonyms	E2F-3
Description	E2F transcription factor 3
Reference	MIM:600427\|HGNC:HGNC:3115\|Ensembl:ENSG00000112242\|HPRD:02693\|Vega:OTTHUMG00000016389
Gene type	protein-coding
Map location	6p22
Pascal p-value	0.069
Sherlock p-value	0.527
Fetal beta	0.309
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
GSMA_I	Genome scan meta-analysis	Psr: 0.033

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg09133386	6	20404188	E2F3	7.39E-10	-0.018	9.98E-7	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs7270082	chr20	17036184	E2F3	1871		0.18		trans
rs7274416	chr20	17040352	E2F3	1871		0.07		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	IEA		-
GO:0003700	transcription factor activity	TAS		8246996
GO:0005515	protein binding	IPI		17438371
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS		8246996
GO:0006350	transcription	IEA		-
GO:0007049	cell cycle	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005654	nucleoplasm	EXP		9190208
GO:0005667	transcription factor complex	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	E2F3 (E2F-3) interacts with the BIRC5 (survivin) promoter.	BIND	15271987
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	E2F3 interacts with the Cdc2 promoter.	BIND	10766737
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	E2F3 interacts with the Cdc25A promoter.	BIND	10766737
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	E2F3 interacts with the Cdc6 promoter.	BIND	10766737
CDK3	-	cyclin-dependent kinase 3	-	HPRD,BioGRID	8846921 \|11733001
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Two-hybrid	BioGRID	12748276
EAPP	BM036 \| C14orf11 \| FLJ20578 \| MGC4957	E2F-associated phosphoprotein	E2F3 interacts with EAPP.	BIND	15716352
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	Two-hybrid	BioGRID	12411495
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	E2F3 interacts with a molecule expressed by Gene FHL2. The precise molecular variant of FHL2 involved in this interaction is not specified.	BIND	12411495
GAB2	KIAA0571	GRB2-associated binding protein 2	The Gab2 promoter region interacts with E2F3.	BIND	15574337
JMY	FLJ37870 \| MGC163496	junction-mediating and regulatory protein	E2F3 interacts with the JMY promoter.	BIND	15706352
MGA	FLJ12634 \| KIAA0518 \| MAD5 \| MXD5	MAX gene associated	Two-hybrid	BioGRID	12748276
MSH2	COCA1 \| FCC1 \| HNPCC \| HNPCC1 \| LCFS2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	E2F3 interacts with the MSH2 promoter.	BIND	11799067
MT1G	MGC12386 \| MT1 \| MT1K	metallothionein 1G	E2F3 interacts with the MT1G promoter.	BIND	15735762
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	E2F3 interacts with the B-myb promoter region.	BIND	10766737
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	Two-hybrid	BioGRID	12748276
PKIB	FLJ23817 \| PRKACN2	protein kinase (cAMP-dependent, catalytic) inhibitor beta	Two-hybrid	BioGRID	12748276
PPP1R13B	ASPP1 \| KIAA0771 \| p53BP2-like \| p85	protein phosphatase 1, regulatory (inhibitor) subunit 13B	E2F3 interacts with the PPP1R13B (ASPP1) promoter.	BIND	15706352
RNF144A	KIAA0161 \| RNF144 \| UBCE7IP4	ring finger protein 144A	Two-hybrid	BioGRID	12411495
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	Affinity Capture-Western Two-hybrid	BioGRID	12411495
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	E2F3 interacts with RYBP.	BIND	12411495
SP1	-	Sp1 transcription factor	-	HPRD	8657141
SPIB	SPI-B	Spi-B transcription factor (Spi-1/PU.1 related)	Two-hybrid	BioGRID	12748276
TEAD3	DTEF-1 \| ETFR-1 \| TEAD5 \| TEF-5 \| TEF5	TEA domain family member 3	Two-hybrid	BioGRID	12748276
TFDP1	DP1 \| DRTF1 \| Dp-1	transcription factor Dp-1	-	HPRD	7739537 \|8755520
TFDP2	DP2 \| Dp-2	transcription factor Dp-2 (E2F dimerization partner 2)	-	HPRD	7739537 \|8755520
TFE3	RCCP2 \| TFEA \| bHLHe33	transcription factor binding to IGHM enhancer 3	-	HPRD,BioGRID	12748276
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	E2F3 interacts with the TP53BP2 (ASPP2) promoter.	BIND	15706352
TP53INP1	DKFZp434M1317 \| FLJ22139 \| SIP \| TP53DINP1 \| TP53INP1A \| TP53INP1B \| Teap \| p53DINP1	tumor protein p53 inducible nuclear protein 1	E2F3 interacts with the TP53INP1 promoter.	BIND	15706352
UXT	ART-27	ubiquitously-expressed transcript	E2F3 interacts with the UXT chromatin.	BIND	11799066
WNK1	KDP \| KIAA0344 \| PHA2C \| PRKWNK1 \| PSK	WNK lysine deficient protein kinase 1	Two-hybrid	BioGRID	12748276
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	-	HPRD	12411495

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	29	17	All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	44	24	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	11	5	All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION	81	45	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	36	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP	137	94	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP	29	20	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS	97	58	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL	330	217	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL	330	215	All SZGR 2.0 genes in this pathway
GRASEMANN RETINOBLASTOMA WITH 6P AMPLIFICATION	14	14	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP	48	23	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1	229	137	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP	121	71	All SZGR 2.0 genes in this pathway
COURTOIS SENESCENCE TRIGGERS	6	5	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11	63	45	All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER	100	62	All SZGR 2.0 genes in this pathway
REN BOUND BY E2F	61	40	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN	123	86	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP	178	111	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D1	18	13	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
LU TUMOR ANGIOGENESIS UP	25	22	All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP	105	75	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
DUAN PRDM5 TARGETS	79	52	All SZGR 2.0 genes in this pathway
RAFFEL VEGFA TARGETS UP	9	8	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	3180	3186	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	3180	3186	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-124/506	418	424	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	418	424	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	1185	1192	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1185	1192	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	2039	2045	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	2039	2045	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-140	1740	1747	1A,m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-141/200a	2603	2610	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
				hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
				hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-145	2029	2035	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152	2037	2043	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497	2491	2498	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	1786	1792	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	1824	1831	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-194	3176	3182	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-200bc/429	2857	2863	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-21	564	570	1A	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	564	570	1A	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-24*	3057	3064	1A,m8	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-25/32/92/363/367	272	278	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-5p	870	876	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-34/449	2730	2737	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-342	1252	1258	m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-370	1111	1117	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-378	1429	1435	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-378	1429	1435	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-433-3p	107	114	1A,m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-448	1785	1792	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-495	3174	3180	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	3125	3131	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-500	1880	1886	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-503	2492	2498	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: E2F3