Gene Page: EEF1B2

Summary ?
GeneID1933
SymbolEEF1B2
SynonymsEEF1B|EEF1B1|EF1B
Descriptioneukaryotic translation elongation factor 1 beta 2
ReferenceMIM:600655|HGNC:HGNC:3208|Ensembl:ENSG00000114942|HPRD:02804|Vega:OTTHUMG00000132891
Gene typeprotein-coding
Map location2q33.3
Pascal p-value0.014
Sherlock p-value0.369
Fetal beta1.716
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00916 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0113 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg067073382207024452EEF1B22.42E-9-0.0121.81E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16841037chr14316543EEF1B219330.04trans
rs11120206chr1206610593EEF1B219330.19trans
rs2716736chr239947946EEF1B219330.04trans
rs6759186chr2230376822EEF1B219330.08trans
rs2713946chr4111197804EEF1B219330.06trans
rs467856chr53128168EEF1B219330.14trans
rs13175086chr5174691428EEF1B219330trans
rs2016128chr642442743EEF1B219330.17trans
rs12255258chr10106306927EEF1B219330.18trans
rs2397390chr10132403765EEF1B219330.15trans
rs4275531chr10132403792EEF1B219330.15trans
rs17570016chr1151428309EEF1B219330.18trans
rs998923chr1335507810EEF1B219330.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DSCAM0.810.78
WASF10.810.79
LMO70.800.81
SSBP30.800.85
TANC20.790.78
KCNK90.780.81
GPD1L0.780.79
AC135352.10.780.78
PRDM20.780.83
SLC35F10.780.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.66-0.71
C11orf67-0.61-0.69
HSD17B14-0.60-0.67
DBI-0.60-0.74
AF347015.31-0.59-0.65
RHOC-0.59-0.70
MT-CO2-0.59-0.66
ACSF2-0.58-0.68
AF347015.21-0.58-0.70
BDH2-0.58-0.64

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003746translation elongation factor activityNAS1886777 
GO:0005515protein bindingIPI16169070 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006414translational elongationEXP15189156 
GO:0006414translational elongationNAS1886777 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10368288 
GO:0005853eukaryotic translation elongation factor 1 complexNAS1886777 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 14296All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 4128All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC DN 5935All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151100All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 6941All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS INTERMEDIATE PROGENITOR 14984All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP 5225All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 8956All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES 6835All SZGR 2.0 genes in this pathway
BILANGES SERUM RESPONSE TRANSLATION 3720All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL UP 2615All SZGR 2.0 genes in this pathway