Gene Page: EEF1B2

Summary
GeneID  1933
Symbol  EEF1B2
Synonyms  EEF1B|EEF1B1|EF1B
Description  eukaryotic translation elongation factor 1 beta 2
See related  HGNC:3208|MIM:600655|Ensembl:ENSG00000114942|HPRD:02804|
Locus tag  -
Gene type  protein-coding
Map location  2q33-q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0113 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DSCAM0.810.78
WASF10.810.79
LMO70.800.81
SSBP30.800.85
TANC20.790.78
KCNK90.780.81
GPD1L0.780.79
AC135352.10.780.78
PRDM20.780.83
SLC35F10.780.81
Top 10 negatively co-expressed genes
SERPINB6-0.66-0.71
C11orf67-0.61-0.69
HSD17B14-0.60-0.67
DBI-0.60-0.74
AF347015.31-0.59-0.65
RHOC-0.59-0.70
MT-CO2-0.59-0.66
ACSF2-0.58-0.68
AF347015.21-0.58-0.70
BDH2-0.58-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003746translation elongation factor activityNAS1886777 
GO:0005515protein bindingIPI16169070 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006414translational elongationEXP15189156 
GO:0006414translational elongationNAS1886777 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10368288 
GO:0005853eukaryotic translation elongation factor 1 complexNAS1886777 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AARS-alanyl-tRNA synthetaseAlaRS interacts with an unspecified isoform of EF-1-beta.BIND11829477 
EEF1A2EEF1AL | EF-1-alpha-2 | EF1A | FLJ41696 | HS1 | STN | STNLeukaryotic translation elongation factor 1 alpha 2Affinity Capture-MSBioGRID17353931 
EEF1B2EEF1B | EEF1B1 | EF1Beukaryotic translation elongation factor 1 beta 2Co-purificationBioGRID10094407 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 |16189514 
HARSFLJ20491 | HRShistidyl-tRNA synthetaseAffinity Capture-Western
Reconstituted Complex		BioGRID11829477 
HRS interacts with EF-1-beta.BIND11829477 
TIMP1CLGI | EPA | EPO | FLJ90373 | HCI | TIMPTIMP metallopeptidase inhibitor 1Two-hybridBioGRID16169070 
VARSG7A | VARS1 | VARS2valyl-tRNA synthetase-HPRD,BioGRID2556394 |3169261 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
KUROKAWA_LIVER_CANCER_CHEMOTHERAPY_DN 4128All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_DN 5935All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR 14984All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
CHNG_MULTIPLE_MYELOMA_HYPERPLOID_UP 5225All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
BILANGES_SERUM_AND_RAPAMYCIN_SENSITIVE_GENES 6835All SZGR genes in this pathway
BILANGES_SERUM_RESPONSE_TRANSLATION 3720All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_UP 2615All SZGR genes in this pathway


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