SZGR2

Summary ?

GeneID	1977
Symbol	EIF4E
Synonyms	AUTS19\|CBP\|EIF4E1\|EIF4EL1\|EIF4F\|eIF-4E
Description	eukaryotic translation initiation factor 4E
Reference	MIM:133440\|HGNC:HGNC:3287\|HPRD:00591\|
Gene type	protein-coding
Map location	4q23
Pascal p-value	0.511
Sherlock p-value	0.315
Fetal beta	0.776
DMG	1 (# studies)
eGene	Myers' cis & trans Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	3
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0067

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg11037477	4	99851008	EIF4E	1.465E-4	0.563	0.031	DMG:Wockner_2014
cg15633390	4	99851211	EIF4E	3.028E-4	0.657	0.04	DMG:Wockner_2014
cg14972143	4	99851003	EIF4E	3.611E-4	0.664	0.042	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs4729109	chr7	93760673	EIF4E	1977		0.18		trans
rs7035652	chr9	117779879	EIF4E	1977		0.08		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AP003117.1	0.79	0.84
CTBS	0.77	0.73
CRYL1	0.77	0.76
TMBIM1	0.77	0.81
SERPINB6	0.76	0.78
GRAMD3	0.75	0.81
LACTB2	0.75	0.78
CD9	0.74	0.80
PIR	0.74	0.75
CSRP1	0.74	0.79

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KIAA1543	-0.60	-0.64
NOVA2	-0.60	-0.64
CHD3	-0.60	-0.63
DPF1	-0.59	-0.64
MARCH4	-0.59	-0.63
ZNF821	-0.59	-0.63
KIAA1949	-0.58	-0.60
MPP3	-0.58	-0.61
GPSM1	-0.58	-0.60
KIF21B	-0.58	-0.62

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000339	RNA cap binding	TAS		3469651
GO:0003743	translation initiation factor activity	ISS		-
GO:0005515	protein binding	IPI		9878069 \|10856257 \|15153109 \|15247416 \|16739988 \|17353931
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006413	translational initiation	IEA		-
GO:0006417	regulation of translation	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		7935836 \|8449919 \|12588972 \|15809305
GO:0005737	cytoplasm	IEA		-
GO:0016281	eukaryotic translation initiation factor 4F complex	TAS		3469651

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
EIF3B	EIF3-ETA \| EIF3-P110 \| EIF3-P116 \| EIF3S9 \| MGC104664 \| MGC131875 \| PRT1	eukaryotic translation initiation factor 3, subunit B	Affinity Capture-Western	BioGRID	16541103
EIF4A1	DDX2A \| EIF-4A \| EIF4A	eukaryotic translation initiation factor 4A, isoform 1	Affinity Capture-MS Affinity Capture-Western	BioGRID	16648488 \|17353931
EIF4A2	BM-010 \| DDX2B \| EIF4A \| EIF4F	eukaryotic translation initiation factor 4A, isoform 2	Affinity Capture-MS	BioGRID	17353931
EIF4E	CBP \| EIF4E1 \| EIF4EL1 \| EIF4F \| MGC111573	eukaryotic translation initiation factor 4E	Affinity Capture-Western	BioGRID	16648488
EIF4EBP1	4E-BP1 \| 4EBP1 \| BP-1 \| MGC4316 \| PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	EIF4E interacts with EIF4EBP1 (4EBP1).	BIND	10022874
EIF4EBP1	4E-BP1 \| 4EBP1 \| BP-1 \| MGC4316 \| PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	-	HPRD,BioGRID	11605658
EIF4EBP2	4EBP2 \| PHASII	eukaryotic translation initiation factor 4E binding protein 2	-	HPRD,BioGRID	7651417 \|7935836
EIF4EBP3	4E-BP3	eukaryotic translation initiation factor 4E binding protein 3	-	HPRD,BioGRID	12482586
EIF4ENIF1	4E-T \| Clast4 \| FLJ21601 \| FLJ26551	eukaryotic translation initiation factor 4E nuclear import factor 1	-	HPRD,BioGRID	10856257
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	-	HPRD,BioGRID	10600798
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	-	HPRD	9372926 \|10600798\|10600798
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	EIF4E interacts with eIF4G1. This interaction was modeled on a demonstrated interaction between mouse eIF4E and human eIF4G1.	BIND	9878069
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	eIF4GI interacts with eIF4E. This interaction was modeled on a demonstrated interaction between human eIF4GI and monkey eIF4E.	BIND	15361857
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	eIF-4E interacts with an unspecified isoform of eIF-4G.	BIND	15897904
EIF4G2	AAG1 \| DAP5 \| FLJ41344 \| NAT1 \| p97	eukaryotic translation initiation factor 4 gamma, 2	Affinity Capture-Western Far Western	BioGRID	9418880
EIF4G2	AAG1 \| DAP5 \| FLJ41344 \| NAT1 \| p97	eukaryotic translation initiation factor 4 gamma, 2	-	HPRD	10394359
EIF4G3	eIF4GII	eukaryotic translation initiation factor 4 gamma, 3	-	HPRD	9418880
MAPKAPK5	PRAK	mitogen-activated protein kinase-activated protein kinase 5	-	HPRD	9628874
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	Affinity Capture-Western	BioGRID	9878069
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	EIF4E interacts with Mnk1. This interaction was modeled on a demonstrated interaction between mouse eIF4E and human Mnk1.	BIND	9878069
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	11500381

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MTOR SIGNALING PATHWAY	52	40	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
BIOCARTA EIF PATHWAY	16	9	All SZGR 2.0 genes in this pathway
BIOCARTA MTOR PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY	20	14	All SZGR 2.0 genes in this pathway
BIOCARTA SARS PATHWAY	10	5	All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY	32	25	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY	38	29	All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION	222	75	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	140	77	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	84	30	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	54	34	All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING	161	86	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	176	51	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	33	21	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION OF MRNA	22	14	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	48	29	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME PKB MEDIATED EVENTS	29	23	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME MTORC1 MEDIATED SIGNALLING	11	8	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE	71	51	All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN	136	86	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS UP	27	17	All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC UP	23	17	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE UP	38	29	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN	517	309	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN	76	52	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN	129	86	All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 DN	15	12	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP	120	89	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D2	41	30	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C4	18	12	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP	93	65	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP	56	41	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1	148	95	All SZGR 2.0 genes in this pathway
THILLAINADESAN ZNF217 TARGETS UP	44	22	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS DN	7	7	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	790	796	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-15/16/195/424/497	496	502	1A	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-150	52	58	m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-186	652	658	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-203.1	709	715	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-205	601	607	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-330	869	875	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-376c	729	735	m8	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-377	737	743	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-493-5p	924	930	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-503	496	502	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-9	63	69	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EIF4E