SZGR2

Summary ?

GeneID	2010
Symbol	EMD
Synonyms	EDMD\|LEMD5\|STA
Description	emerin
Reference	MIM:300384\|HGNC:HGNC:3331\|Ensembl:ENSG00000102119\|HPRD:02309\|Vega:OTTHUMG00000033186
Gene type	protein-coding
Map location	Xq28
Sherlock p-value	0.81
Fetal beta	0.318
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg09229960	X	153607856	EMD	1.712E-4	5.115		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	-	HPRD	12670476
ACTG2	ACT \| ACTA3 \| ACTE \| ACTL3 \| ACTSG	actin, gamma 2, smooth muscle, enteric	Affinity Capture-Western Reconstituted Complex	BioGRID	12670476
AKAP8L	DKFZp434L0650 \| HA95 \| HAP95 \| NAKAP \| NAKAP95	A kinase (PRKA) anchor protein 8-like	-	HPRD,BioGRID	11034899
BANF1	BAF \| BCRP1 \| D14S1460 \| MGC111161	barrier to autointegration factor 1	Emerin interacts with BAF.	BIND	11792821
BANF1	BAF \| BCRP1 \| D14S1460 \| MGC111161	barrier to autointegration factor 1	-	HPRD,BioGRID	11792822
BCLAF1	BTF \| KIAA0164 \| bK211L9.1	BCL2-associated transcription factor 1	-	HPRD	15009215
BEND7	C10orf30 \| FLJ40283 \| MGC35247	BEN domain containing 7	Two-hybrid	BioGRID	16189514
COPS6	CSN6 \| MOV34-34KD	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	Two-hybrid	BioGRID	16169070
CREB3	LUMAN \| LZIP \| MGC15333 \| MGC19782	cAMP responsive element binding protein 3	Two-hybrid	BioGRID	16189514
DPPA4	2410091M23Rik \| FLJ10713	developmental pluripotency associated 4	Two-hybrid	BioGRID	16169070
FATE1	FATE	fetal and adult testis expressed 1	Two-hybrid	BioGRID	16189514
GMCL1	BTBD13 \| GCL \| GCL1	germ cell-less homolog 1 (Drosophila)	-	HPRD,BioGRID	12493765
LMNA	CDCD1 \| CDDC \| CMD1A \| CMT2B1 \| EMD2 \| FPL \| FPLD \| HGPS \| IDC \| LDP1 \| LFP \| LGMD1B \| LMN1 \| LMNC \| PRO1	lamin A/C	-	HPRD,BioGRID	10673356 \|11173535
LMNB1	ADLD \| LMN \| LMN2 \| LMNB \| MGC111419	lamin B1	Affinity Capture-Western	BioGRID	12670476
LPL	HDLCQ11 \| LIPD	lipoprotein lipase	Two-hybrid	BioGRID	12755701
PSME1	IFI5111 \| MGC8628 \| PA28A \| PA28alpha \| REGalpha	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	Affinity Capture-Western Two-hybrid	BioGRID	12755701
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	Two-hybrid	BioGRID	16169070
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	Two-hybrid	BioGRID	16169070
SYNE1	8B \| CPG2 \| DKFZp781J13156 \| FLJ30878 \| FLJ41140 \| KIAA0796 \| KIAA1262 \| KIAA1756 \| MYNE1 \| SCAR8	spectrin repeat containing, nuclear envelope 1	-	HPRD,BioGRID	12163176
VAV1	VAV	vav 1 guanine nucleotide exchange factor	Two-hybrid	BioGRID	12755701
YTHDC1	KIAA1966 \| YT521 \| YT521-B	YTH domain containing 1	-	HPRD,BioGRID	12755701

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC	76	59	All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY	92	68	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP	380	213	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP	116	79	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 2HR	51	36	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN	210	128	All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP	109	68	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN	113	76	All SZGR 2.0 genes in this pathway
WIERENGA PML INTERACTOME	42	23	All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP	107	72	All SZGR 2.0 genes in this pathway

Gene Page: EMD