Gene Page: EPB42

Summary ?
GeneID2038
SymbolEPB42
SynonymsPA|SPH5
Descriptionerythrocyte membrane protein band 4.2
ReferenceMIM:177070|HGNC:HGNC:3381|Ensembl:ENSG00000166947|HPRD:01517|Vega:OTTHUMG00000130701
Gene typeprotein-coding
Map location15q15-q21
Pascal p-value0.01

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0494 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C9orf610.790.84
PIPOX0.780.83
BDH20.780.85
ANKRD350.780.79
HADHB0.770.84
NPL20.760.83
A2ML10.760.76
ADHFE10.760.84
PBXIP10.750.84
FAH0.750.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NOL4-0.54-0.65
DPF1-0.53-0.64
ARL4D-0.52-0.61
MYT1L-0.52-0.64
PRKAR2B-0.52-0.64
GPRIN1-0.52-0.62
MEF2C-0.52-0.67
PPAPR5-0.51-0.65
CECR6-0.51-0.60
PLK2-0.51-0.63

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003810protein-glutamine gamma-glutamyltransferase activityIEA-
GO:0005515protein bindingIPI12970870 
GO:0005524ATP bindingTAS8608138 
GO:0005200structural constituent of cytoskeletonTAS1350227 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008360regulation of cell shapeIEA-
GO:0018149peptide cross-linkingIEA-
GO:0043249erythrocyte maturationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonTAS1350227 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneTAS1350227 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS DN 6639All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN 6536All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293160All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 8550All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225124All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
STEINER ERYTHROCYTE MEMBRANE GENES 1510All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway