Summary ?
GeneID2042
SymbolEPHA3
SynonymsEK4|ETK|ETK1|HEK|HEK4|TYRO4
DescriptionEPH receptor A3
ReferenceMIM:179611|HGNC:HGNC:3387|Ensembl:ENSG00000044524|HPRD:01555|Vega:OTTHUMG00000159040
Gene typeprotein-coding
Map location3p11.2
Pascal p-value0.291
Fetal beta3.303

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.04047 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04359 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DGAT10.770.72
FBXO170.750.75
TMEM161A0.750.78
LRRC4B0.750.73
RNF1260.740.75
TMEM1800.740.72
CHST120.740.72
AGPAT10.740.73
VAC140.740.71
SCAP0.730.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.55-0.52
AL139819.3-0.53-0.55
AF347015.8-0.51-0.47
AF347015.31-0.50-0.46
AF347015.27-0.49-0.48
MT-ATP8-0.49-0.49
MT-CO2-0.49-0.45
MT-CYB-0.48-0.44
NOSTRIN-0.47-0.42
AF347015.18-0.46-0.51

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005003ephrin receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS1737782 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1737782 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID11870224 
EFNA1B61 | ECKLG | EFL1 | EPLG1 | LERK1 | TNFAIP4ephrin-A1Reconstituted ComplexBioGRID9195962 
EFNA2ELF-1 | EPLG6 | HEK7-L | LERK6ephrin-A2-HPRD9751130 
EFNA3EFL2 | EPLG3 | Ehk1-L | LERK3ephrin-A3Reconstituted ComplexBioGRID9195962 
EFNA4EFL4 | EPLG4 | LERK4 | MGC125826ephrin-A4Reconstituted ComplexBioGRID9195962 
EFNA5AF1 | EFL5 | EPLG7 | GLC1M | LERK7 | RAGSephrin-A5-HPRD,BioGRID9195962 
EFNA5AF1 | EFL5 | EPLG7 | GLC1M | LERK7 | RAGSephrin-A5-HPRD9195962|9751130 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1Reconstituted ComplexBioGRID9195962 
EFNB2EPLG5 | HTKL | Htk-L | LERK5 | MGC126226 | MGC126227 | MGC126228ephrin-B2-HPRD,BioGRID8559144 
RUFY1FLJ22251 | RABIP4 | ZFYVE12RUN and FYVE domain containing 1-HPRD11877430 
RUFY2FLJ10063 | KIAA1537 | RABIP4R | ZFYVE13RUN and FYVE domain containing 2-HPRD11877430 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Reconstituted ComplexBioGRID15355990 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY 3429All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169118All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE UP 2820All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 11679All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 8657All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED SIGNIFICANTLY 2622All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 12860All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 9264All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE UP 9761All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 10575All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
PLASARI NFIC TARGETS BASAL DN 1813All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/984604661Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-124.11351421A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061351411Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-13524522458m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1827127181Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1946997051Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-29976982m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-325227222781Ahsa-miR-325CCUAGUAGGUGUCCAGUAAGUGU
miR-381930936m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-487b22452251m8hsa-miR-487bAAUCGUACAGGGUCAUCCACUU
miR-488470476m8hsa-miR-488CCCAGAUAAUGGCACUCUCAA
miR-4956977031Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496255825641Ahsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
miR-7129613031A,m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-967117181A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC