Summary ?
GeneID2047
SymbolEPHB1
SynonymsELK|EPHT2|Hek6|NET
DescriptionEPH receptor B1
ReferenceMIM:600600|HGNC:HGNC:3392|Ensembl:ENSG00000154928|HPRD:02790|Vega:OTTHUMG00000159804
Gene typeprotein-coding
Map location3q22.2
Pascal p-value0.33
Fetal beta0.873
eGeneCerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407EPHB120472.844E-14trans
rs7584986chr2184111432EPHB120470trans
rs6741060chr2217169088EPHB120470.06trans
snp_a-18157710EPHB120470.01trans
rs17020035chr493873810EPHB120470.15trans
rs17020058chr493915972EPHB120470.15trans
rs17020066chr493921055EPHB120470.15trans
rs10491487chr580323367EPHB120470.09trans
rs6996695chr877540580EPHB120470.16trans
rs11139334chr984209393EPHB120479.877E-4trans
rs2393316chr1059333070EPHB120470.1trans
rs11061703chr121436977EPHB120470.11trans
rs9989228chr1437809252EPHB120470.03trans
rs16955618chr1529937543EPHB120475.685E-10trans
rs2077735chr1558479024EPHB120470trans
rs9941296chr162759498EPHB120470.17trans
rs11873184chr181584081EPHB120470.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005003ephrin receptor activityIEA-
GO:0005515protein bindingIPI8798570 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8666391 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS8666391 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS8666391 
GO:0005887integral to plasma membraneTAS8666391 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
BIOCARTA EPHA4 PATHWAY 108All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 3025All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184125All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
YEMELYANOV GR TARGETS DN 108All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA HP UP 4926All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 8255All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY DN 5839All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p661667m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-1406766831A,m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-1825415481A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-186399405m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-28509515m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-4506616671Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-4527817881A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-53912661272m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-965425481Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC