SZGR2

Summary ?

GeneID	204851
Symbol	HIPK1
Synonyms	Myak\|Nbak2
Description	homeodomain interacting protein kinase 1
Reference	MIM:608003\|HGNC:HGNC:19006\|Ensembl:ENSG00000163349\|HPRD:06418\|Vega:OTTHUMG00000011983
Gene type	protein-coding
Map location	1p13.2
Pascal p-value	0.565
Fetal beta	0.234
DMG	1 (# studies)
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
GSMA_I	Genome scan meta-analysis	Psr: 0.0235

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
ch.1.2681285F	1	114503218	HIPK1	2.628E-4	-1.216	0.038	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003677	DNA binding	IEA		-
GO:0005515	protein binding	IPI		12529400 \|12702766
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0016301	kinase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN	136	86	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP	108	67	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN	205	127	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1	229	137	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP	283	177	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN	64	47	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION	88	68	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP	156	101	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4	94	69	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME GRAY	15	10	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
NUTT GBM VS AO GLIOMA UP	46	34	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP	61	41	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE	151	86	All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS DN	53	29	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1488	1494	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	1671	1677	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124.1	1671	1677	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1625	1632	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-136	2517	2523	1A	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-139	1489	1495	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-141/200a	1382	1389	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1382	1389	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-5p	3783	3790	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-142-5p	3783	3790	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-143	995	1001	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-144	1488	1494	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-146	1858	1865	1A,m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	1858	1865	1A,m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-185	998	1004	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-19	1548	1555	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1548	1555	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429	4217	4223	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-203.1	3497	3503	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-214	3154	3160	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-221/222	3833	3840	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	3833	3840	1A,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-26	1347	1353	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1347	1353	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p	1422	1428	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	1657	1663	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	1803	1809	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	3791	3797	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-329	1365	1371	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-329	1365	1371	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-33	4257	4263	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	4257	4263	m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-330	3879	3886	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-342	1918	1924	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-365	1510	1516	m8	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU
miR-381	4207	4213	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	3786	3792	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-493-5p	3850	3856	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-493-5p	3850	3856	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	3653	3659	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-495	3653	3659	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	4078	4084	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-500	2508	2514	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-505	170	176	m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-543	1314	1320	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-543	1314	1320	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-9	2108	2115	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HIPK1