Gene Page: EPHB4

Summary ?
GeneID2050
SymbolEPHB4
SynonymsHTK|MYK1|TYRO11
DescriptionEPH receptor B4
ReferenceMIM:600011|HGNC:HGNC:3395|Ensembl:ENSG00000196411|HPRD:02481|Vega:OTTHUMG00000157040
Gene typeprotein-coding
Map location7q22
Pascal p-value0.039
Fetal beta0.948
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
ExpressionMeta-analysis of gene expressionP value: 2.016 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg018691867100423987EPHB42.273E-4-0.2830.036DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TTYH20.960.87
C11orf90.960.92
LDB30.950.91
PLEKHH10.950.80
SGK20.950.87
GALNT60.950.89
SH3TC20.940.91
AC022100.10.940.87
ATPGD10.940.92
C10orf900.940.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NR2C2AP-0.54-0.74
MED19-0.54-0.71
ALKBH2-0.54-0.74
POLB-0.53-0.74
TRNAU1AP-0.53-0.68
NKIRAS2-0.53-0.62
HN1-0.52-0.68
CCDC28B-0.52-0.77
TUBB2B-0.52-0.69
STMN1-0.52-0.68

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008046axon guidance receptor activityIEAaxon (GO term level: 6)-
GO:0005102receptor bindingIEANeurotransmitter (GO term level: 4)-
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005003ephrin receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0048170positive regulation of long-term neuronal synaptic plasticityIEAneuron, neurogenesis, Synap (GO term level: 11)-
GO:0048168regulation of neuronal synaptic plasticityIEAneuron, Synap (GO term level: 9)-
GO:0050770regulation of axonogenesisIEAneuron, axon (GO term level: 13)-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0009887organ morphogenesisTAS8831703 
GO:0008283cell proliferationTAS8152808 
GO:0007612learningIEA-
GO:0045765regulation of angiogenesisNAS16322467 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA12493773 
GO:0005887integral to plasma membraneTAS8188704 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 3025All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182111All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240171All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR UP 2719All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214133All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 13784All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA 6947All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 9258All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175116All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN 7657All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 3926All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 4 4832All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287208All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 UP 11370All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C6 55All SZGR 2.0 genes in this pathway
NOUSHMEHR GBM SOMATIC MUTATED 97All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway